Integrins are a superfamily of transmembrane cell surface receptors that mediate signal transduction, cell-to-cell interaction, and cell-to-extracellular matrix adhesion - key processes for healthy cells as well as progression of disease states such as atherosclerosis and cancer, where integrins contribute to angiogenesis, tumorigenesis, and metastasis.
Among this superfamily, αvβ3 integrin holds promise as a therapeutic target in areas such as immuno-oncology, where αvβ3 integrin may prevent tumors from evading the immune system. 爱游戏平台注册登录 's IVISsense™ Integrin Receptor fluorescent probes (IntegriSense™) are designed to target αvβ3 integrin for monitoring tumor growth, angiogenesis and assessing treatment efficacy.
For research use only. Not for use in diagnostic procedures.
false false
IVISense Integrin Receptor 680 fluorescent imaging probe for in vivo detection of αvβ3 integrin is a low molecular weight peptidomimetic antagonist coupled to a red fluorochrome. This validated, high affinity (Kd = 4.2 nM) fluorescent probe has improved circulation half-life and specificity over RDG peptide-based agents, with selectivity 5-20x for αvβ3 integrin, for precise detection of αvβ3 integrins. This integrin-targeted molecular imaging agent enables non-invasive imaging to better understand biological processes, and disease biology and progression.
Including IVISense Integrin Receptor 680 fluorescent agent in careful experimental design allows for multiplexing with other channels and/or imaging times, and can be paired with other probes to achieve maximum efficiency and flexibility in your imaging studies.
| 熒光劑類型 | Targeted |
|---|---|
| 光學成像分類 | Fluorescence Imaging |
| 產品品牌名稱 | IVISense |
| 包裝量 | 1.0 Units |
| 運輸條件 | 藍冰 |
| 治療領域 | Angiogenesis, Atherosclerosis, Oncology/Cancer |
| 產品尺寸 | 1 Vial (10 doses) |
| 波長 | 680 nm |
Researchers trust our in vivo imaging solutions to give them reliable, calibrated data that reveals pathway characterization and therapeutic efficacies for a broad range of indications. Our reagents, instruments, and applications support have helped hundreds of research projects over the years. And ...
Our comprehensive range of bioluminescent and fluorescent imaging reagents provide researchers with the necessary tools to better understand early disease-related biological changes, track disease progression, help guide the drug discovery process, and evaluate efficacy and safety of drug candida ...
Integrins are a superfamily of transmembrane cell surface receptors that mediate signal transduction, cell-to-cell interaction, and cell-to-extracellular matrix adhesion - key processes for healthy cells as well as in the progression of disease states such as cancer.
Among this superfamily, ...
Fluorescence molecular imaging is the visualization of cellular and biological function in vivo to gain deeper insights into disease processes and treatment effects. Designing an effective study from the beginning can help save time and resources.
Learn about several important best p ...
Current means of measuring disease in preclinical models of atherosclerosis include ex vivo assessment of disease tissues post-mortem and non-invasive imaging primarily of structural and anatomic features of lesions, in vivo. A non-invasive, quantitative means of imaging known biologic profiles asso ...
IntegriSense 680 in vivo fluorescent imaging protocol
The goal of in vivo fluorescence molecular imaging is to enable non-invasive visualization and quantification of cellular and biological functioning to better understand and characterize disease processes and treatment effects earlier within the context of a biological system.
This s ...
Integrins are a family of transmembrane glycoproteins which play a crucial role in the pathogenesis of various diseases, including cancer, and as such represent viable biomarkers for the progression of these diseases. We have developed IntegriSense 680, an integrin-targeted molecular imaging agent t ...
Breast cancer is a clinical challenge today, with almost 200,000 new breast cancer cases reported annually in the United States alone. In 10% of breast cancer diagnoses, the cancer has metastasized to distant organs,in the body such as bone, liver, and lung, decreasing the 5-year relative survival r ...
Integrins are a family of transmembrane glycoproteins which play a crucial role in the pathogenesis of various diseases, including cancer, and as such represent viable biomarkers for the progression of these diseases. We have developed IntegriSense™ 680, an integrin-targeted molecular imaging agent ...
The primary goal of preclinical imaging is to improve the odds of clinical success and reduce drug discovery and development time and costs. Advances in non-invasive in vivo imaging techniques have raised the use of animal models in drug discovery and development to a new level by enabling quick ...
