The immunogenic potential of biotherapeutic drug molecules can have an effect at any point from its administration through metabolism and elimination. Therefore, it is important to understand the impact of immunogenicity upon the pharmacokinetic (PK) and pharmacodynamic (PD) properties of a large molecule drug.
Subsequently, the characterization of the effect of anti-drug antibodies (ADA) on the PK is critical. The development of a physiologically relevant PK model in the context of the immunogenicity profile offers significant value to preclinical development.
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爱游戏平台注册登录 offers automated microfluidic devices, simplifying the analysis of nucleic acid concentration and qualitative assessment of PCR products, and replacing the multiple manual steps of slab gel electrophoresis with high levels of accuracy.
Sample preparation and characterization of proteins for quality by design (QbD) studies are important parts of process development; however, these studies, including design of experiments(DoE), can be time-consuming, and sample analysis can easily exceed the capacity of most labs.
Miniaturization of small-scale protein purification provides greater process optimization with larger QbD and DoE studies allowing for parallel processing of samples for increased statistical significance and a greater breadth of variables within experimental shorter time frames.
Delivering fast, longitudinal, real-time quantitative assessment of drug candidates, non-invasive in vivo imaging enables physiological assessment, including:
Multiparametric data points from fewer subjects enable reduction in animal usage, streamlining drug assessment and lowering costs.
Today live-cell imaging assays can be performed using instruments designed specifically for this purpose, as well as with high-content screening systems.
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Our high-content screening systems, Opera Phenix™ Plus and Operetta CLS™ have the flexibility to run live-cell assays, combining the benefits of observing live-cells over time with the quantitative, multiparametric data analysis required in drug discovery programs.
In addition, the Opera Phenix Plus system is equipped with fast frame rate imaging and has the option of on-board liquid handling to enable "dispense and read" live-cell fast response assays.
Turn your biological data into knowledge.
The need for high performance and reliability are a given for QC labs performing assays to determine the strength and content of drug substances. Our proven, rugged, and reliable LC 300 system is the perfect choice when you need fast cycle times, reproducibility, and low carryover. With its elegant streamlined interface, the LC 300 range is easy to use and simplifies your day-to-day processes so you can focus on your applications.
Our analytical solutions, including a full suite of chromatography data system (CDS) software packages, consumables and service offerings, come together to deliver a total liquid chromatography solution to increase your throughput, reduce costs and limit unnecessary complexity in analytical processes.
