ChromegaChiral™ columns come in several different varieties such as: CC2, CC3, CC4, CCA, CCA F4, CCC, CCJ, CCO, CCO F2, CCO F4, CCO F4 T3, CCS, CCU, and CCX, to suit your HPLC needs. Chirality has become critically important in the pharmaceutical, chemical, and agricultural industries. The subtle differences that make compounds chiral can produce dramatically different pharmacological effects in biological systems. As a result, the demand for stereoselective separation techniques and analytical assays to evaluate the enantiomeric purity of chiral compounds, has increased. Chiral chromatography in the forms of HPLC and SFC has become a necessary tool - not only for the analytical determination of enantiomeric purity, but also for the isolation and purification of enantiomers.
As a leader in chiral separations we are able to offer you a broad range of our ChromegaChiral Chiral Stationary Phases (CSPs) for your analytical and preparative chromatography needs. Existing chiral stationary phases can separate a wide variety of chiral mixtures, however there are still enantiomeric mixtures that are difficult to separate limiting their characterization. This provides our drive to develop new CSPs with differing chiral selectivities.
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ChromegaChiral™ CCU is a modified amylose coated on high purity, high performance spherical silica particles. The chemical modification includes the combination of chemical bonding groups of methylbenzylcarbamate and 3-chloro-4 methylphenylcarbamate attached to amylose. This combination of bonded groups stabilizes the solubility of coated phase making for a durable phase similar to other widely used coated phases. The use of amylose modified with phenyl groups provides for the separation for many previously unresolved/poorly resolved chiral mixtures.
ChromegaChiral™ CCO F4 T3 (tris(4-Fluoro-3-(trifluoromethylphenyl carbamate) cellulose) incorporates fluoro groups into its structure, and can be used in SFC or HPLC. The addition of a fluorine atom into a phenyl cellulose structure can be useful in promoting fluorophilic retention mechanism which can provide improved retention for fluorinated compounds. A fluorophilic retention mechanism can be particular useful in medicinal chemistry and drug discovery, where more than a third of newly approved small molecule drugs contain fluorine.
ChromegaChiral™ CCA F4 is a tris(4-Fluoro 3-methylphenylcarbamate) amylose phase which can be used in SFC or HPLC. ChromegaChiral CCA F4 incorporates a fluoro group in its structure. The addition of a fluorine atom into a phenyl carbamate amylose structure can be useful in promoting fluorophilic retention mechanism which can provide improved retention for fluorinated compounds. A fluorophilic retention mechanism can be particularly useful in medicinal chemistry and drug discovery, where more than a third of newly approved small molecule drugs contain fluorine.
ChromegaChiral™ CC3 (amylose tris(5-chloro-2-methylphenylcarbamate)) is for high resolution chiral separations based on a new halogenated carbohydrate based chiral stationary phase. Similar in selectivity to CHIRALPAK® AY-H. ChromegaChiral CC3 can provide superior chiral separations, sample loading and superior peak shape performance.
A modified cellulose including 3-chloro-4 methylphenylcarbamate bonding groups coated on high purity, high performance spherical silica particles. This combination of bonded groups stabilizes the solubility of coated phase making for a durable phase similar to other widely used coated phases and provides for similar separation behaviour to Phenomenex Lux® Cellulose-2.
ChromegaChiral™ CCX is a modified amylose coated on high purity, high performance spherical silica particles. The chemical modification includes the combination of chemical bonding groups of methylbenzylcarbamate and 3,5-dimethylphenylcarbamate attached to amylose. This combination of bonded groups stabilizes the solubility of coated phase, making for a durable phase similar to other widely used coated phases. The use of amylose modified with phenyl groups moiety provides for the separation for many previously unresolved/poorly resolved chiral mixtures. This chemical modification provides for unique separation behaviour.
ChromegaChiral™ CCS (amylose tris [(S)-α-methylbenzylcarbamate]) permits the enantiomeric separation of 1-Indanol without the addition of DEA (Diethyl amine). Historically DEA has been commonly used to improve peak shape for chiral separations of compounds such as 1-Indanol. ChromegaChiral CCS separates the 1-Indanol enantiomers with sharp peaks without DEA, providing superior chiral separations, sample loading and peak shape performance. Similar in selectivity to CHIRALPAK® AS-H.
ChromegaChiral™ CCO F4 is a tris(4-Fluoro 3-methylphenylcarbamate) cellulose phase which can be used in SFC or HPLC. The addition of a fluorine atom into a phenyl carbamate cellulose structure is useful in promoting a fluorophilic retention mechanism which provides improved retention for fluorinated compounds. A fluorophilic retention mechanism is particularly useful in medicinal chemistry and drug discovery, where more than a third of newly approved small molecule drugs contain fluorine.
ChromegaChiral™ CCO F2 is a tris(2-Fluoro 5-methylphenylcarbamate) cellulose phase which can be used in SFC or HPLC. The addition of a fluorine atom into a phenyl carbamate cellulose structure can be useful in promoting a fluorophilic retention mechanism which can provide improved retention for fluorinated compounds. A fluorophilic retention mechanism can be particularly useful in medicinal chemistry and drug discovery, where more than a third of newly approved small molecule drugs contain fluorine.
A polysaccharide coated chiral stationary phase and columns which are produced using a unique production process of coating the proven chiral selector, tris-(3,5-dimethylphenylcarbamate) cellulose on high purity, high performance silica. ChromegaChiral™ CCO columns are similar in selectivity to CHIRALCEL® OD.
ChromegaChiral™ CCJ (cellulose tris(4-methylbenzoate)) is a new product for high resolution chiral separations based on a new halogenated carbohydrate based chiral stationary phase. Similar in selectivity to CHIRALCEL® OJ-H.
A modified cellulose including the combination of 3-chloro-4-methylphenylcarbamate and 3,5-dichlorophenylcarbamate bonding groups coated on high purity, high performance spherical silica particles. This combination of bonded groups stabilizes the solubility of coated phase making for a durable phase similar to other widely used coated phases. The use of cellulose modified with chlorinated phenyl groups provides for the separation for many previously unresolved/poorly resolved chiral mixtures by providing unique separation characteristics.
A polysaccharide coated chiral stationary phase and columns which are produced using a unique production process of coating the proven chiral selector, tris-(3,5-di-methylphenyl) carbamate amylose on high purity silica gel. ChromegaChiral™ CCA columns, similar in selectivity to ChiralPak® AD.
ChromegaChiral™ CC4 (cellulose tris(4-chloro-3-methylphenylcarbamate)) is another new product for high resolution chiral separations based on a new halogenated carbohydrate based chiral stationary phase. It is a modified cellulose coated on high purity, high performance spherical silica particles. The chemical modification includes the chemical bonding of 4-chloro-3 methylphenylcarbamate to cellulose. The use of cellulose modified with chlorinated phenyl groups provides a separation opportunity for many previously unresolved and poorly resolved chiral mixtures. Similar in selectivity to CHIRALCEL® OZ-H.
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