Drug Discovery Workflows

Cloning & Plasmid Extraction

Cloning & Transfection into E. coli;  Plasmid Extraction using Macherey-Nagel NucloSpin^® Kit

This explorer^™ G3 workstation has been configured to automate cloning, transfection, and extraction of plasmid DNA.

Configuration Requirements:

• JANUS^® G3 Expanded platform with 8-tip and MDT(96) pipetting arm and gripper integration platform
• Integrated VICTOR^® Nivo^™ Multimode plate reader
• Integrated  Cytomat^™ 2C-LiN Plate incubator
• Integrated Liconic^® LPX110^™ Plate hotel
• Integrated Agilent^® Technologies centrifuge
• Enclosure
• plate::works^™ scheduling software

High Throughput Screening

This explorer G3 workstation was designed to accommodate a broad range of HT screening technologies.

Configuration Requirements:

• Support for wide range of biochemical as well as imaging based screening technologies, all necessary key instruments fully integrated
• Highly flexible platform supporting parallel method execution, independent (offline) use of detection instruments
• Supports for 96, 384 and 1536-well plates
• Integrated Opera^® Phenix^™ high content imager
• Integrated EnVision^® HTS Multimode Reader
• Integrated Operetta CLS^™ high content imaging reader
• Beckman^®/Labcyte^® ECHO^® for nL drug transfer
• Automated incubator and plate hotel
• Choice of integrated dispenser (3x unit stacked) and supporting instruments (Sealer, peeler, centrifuge)
• Laser barcode reader for sample tracking
• plate::works^™ scheduling software

Synthetic Biology

High-Throughput enzyme stability and activity testing, bacteria culturing, colony picking

This explorer^™ G3 workstation was configured to automate the picking and cultivation of bacteria and yeast colonies and to test for activity.

Configuration Requirements:

• Integrated JANUS^® G3 Mini 8-tip and JANUS^® G3 Mini MDT liquid handling workstations
• Integrated EnVison^® Multimode reader
• Integrated KBioSystem^® K6-3 colony picker
• Integrated Hettich^® Rotata centrifuge
• Integrated Liconic^® STX44 incubator with shaking option
• Integrated Brooks^® Xpeel^® plate seal remover
• Integrated Agilent^® Technologies PlateLoc^™ sealer
• Integrated Scinomix^® Sci-Print MP barcode labeler
• Random access storage racks
• Lid handler
• Laser barcode reader for sample tracking
• System enclosure with HEPA Filter
• plate::works^™ scheduling software