Epigenetic Research Reagents

As the understanding of the role of epigenetic changes in various disease states advances, the need for high quality reagents that can rapidly identify and validate therapeutic molecules that target these enzymes is increasing.

Our epigenetics assay portfolio includes:

• Cellular detection kits – these AlphaLISA^® kits enable rapid and direct detection of endogenous modifications of epigenetic marks on histon H3
• In vitro assay toolbox – consists of validated off-the-shelf reagents for the detection of post-translational modifications at histone H3, H4 and p53
• ³H-SAM Methylation assay – enables both quantitative kinetic measure of substrate methylation rates and the measure of methyltransferases with low activity utilizing the gold standard reagent for the study of histone methylation – Adenosyl-L-Methionine, S-[methyl-3H]; (3H-SAM)

Benefits of epigenetic kits and assays include:

• Flexibility: Work with peptide or full-length protein substrates, or endogenous histones in biochemical or cell-based format
• Sensitivity: Robust and reproducible detection, even at low enzyme concentrations
• Specificity: Reagents highly specific for the mark of interest
• Simplicity: One-well, no-wash assay platforms amendable to automation and HTS
• Validated: Detailed, ready-to-use protocols for over 30 epigenetic enzyme assays

Whether you need an epigenetics kit or validated assay, our suite of epigenetic research reagents offers a faster, more efficient path in the race to identify promising epigenetic drug candidates.