High-Content Screening Research Areas

Cancer Research

Cellular imaging has revolutionized cancer biology by enabling cells to be seen more clearly and in more detail as well as creating meaningful functional assays for the development of drugs which prevent tumor growth and metastasis.

Cancer is a class of diseases in which a group of cells display new properties, such as hyperactive growth and division, protection against programmed cell death, loss of respect for normal tissue boundaries, and the ability to become established in diverse tissue environments.

Cancer research is an intense scientific effort to understand and discover disease processes and discover possible therapies. Advanced cellular imaging techniques allow us to visualize important aspects of cancer including tumor cell mobility, invasion, metastasis and angiogenesis.

Scientists can distinguish host cells from a tumor with single-cell resolution. Visualization of many aspects of cancer initiation and progression in vivo is now possible, providing greater context and more accuracy to cancer research.

Neuroscience

Infectious Diseases

Toxicity

Undesired toxic side effects are still amongst the most common reasons for failure of new chemical entities during late stage drug development and can even lead to costly withdrawals of approved drugs from the market. It is therefore necessary to assess compounds in the early phases of the discovery process reliably for potential geno-, hepato-, nephro and cardiotoxic liabilities in order to reduce development costs and increase research efficiency. High content screening is a cost effective tool to run dedicated toxicity tests on relevant model systems.

Such dedicated assays include micronuclei assays to identify genotoxic effects, cell health studies on heptatocytes and kidney cells, advanced assays on liver microtissues, or using primary human cells, hypertrophy studies on cardiomyocytes.

But even functional drug discovery HCS assays can provide important information on potential unwanted properties of a compound in addition to the primary effect readout.

Stem Cell Research

High-content analysis is a powerful technology to analyze stem cell differentiation efficiently under a large variety of conditions and over long periods of times. Scientists are able visualize and analyze complex cellular processes, identify and characterize cells in their various stages of development.

Stem cell research has the potential to make a huge impact on a wide range of human health problems. Stem cell research could facilitate the development of new treatments for human diseases such as diabetes and Parkinson’s, aid the treatment and prevention of medical conditions resulting from abnormal cell division and cell differentiation, and enable the testing of new drugs without the need for animals or human testers. It could also provide a renewable source of replacement cells and tissues to treat diseases such as Alzheimer's disease, stroke, heart disease, osteoarthritis and rheumatoid arthritis.

For this fast paced area of research, 爱游戏平台注册登录 provides state-of-the-art high content screening solutions to stem cell researchers all over the world. Our dedicated team of HCS specialists have an in-depth understanding of the imaging-based stem cell applications and will help you choose the right solution for your research requirements.