The latest line of reversed phase columns for the analysis of biological compounds is MacroSep BIO-Gold. MacroSep Bio-Gold packings are based on ultra-high purity spherical silica, state-of-the-art high-density bonding and full end capping for the separation or purification of high molecular weight bio compounds such as proteins and peptides. Significant improvements in acidic and alkaline resistance have been achieved with MacroSep BIO-Gold.
MacroSep BIO-Gold columns are manufactured utilizing tight process control of the silica, bonding and column packing processes. They are available in a 400 Å pore size which extends the molecular weight range for analysis over the traditional 300 Å materials while providing the same separation capacity as the 300 Å materials. MacroSep BIO-Gold has also been engineered to utilize 1200 Å to allow for the analysis of very high molecular weight samples. In addition, MacroSep BIO-Gold columns utilize the latest in column packing technology to provide for exceptional efficiency, symmetry, and reproducibility. They are available in 1.9 μm, 3 μm, 5 μm and 10 μm particle sizes for analytical and preparative chromatography.
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The 10 mm guard cartridge holder provides protection against compounds that irreversibly absorb onto the stationary phase. It also provides the ultimate in column protection with a selectable filter frit for elimination of particulates along with a guard cartridge packed with a selectable stationary phase to protection against compounds that irreversibly absorb onto the stationary phase.
MacroSep® BIO-Gold PFP exhibits the strongest π-π interaction of all the BIO-Gold phases. The most hydrophilic of the BIO-Gold phenyl phases and may be used for fluorine modified biologics based upon a fluorophilicity interaction. Fluorinated phases such as pentafluorophenyl (PFP) with the highest π-π interaction of any the MacroSep BIO series stationary phases are of great importance in HPLC because their selectivity is orthogonal to the selectivity of traditional alkyl phases (C18, C8, C4 etc.). In addition, it may be useful for fluorine modified biologics based upon a fluorophilicity interaction.
MacroSep® BIO-Gold Naphthyl is based upon bonded planar naphthalene groups and has the highest bonding density and surface coverage of all the MacroSep Bio-Gold phases, providing maximum hydrophobic interaction and superior inertness. It is suitable for variety of solute interactions including π-π and hydrophobic. Ideal for the separation of high MW peptides and oligonucleic acids.
MacroSep® BIO-Gold HPR significantly reduces the hydrophobic interaction of the stationary phase. This reduced interaction can yield less retention of hydrophobic biological molecules, yielding better recoveries and quicker separations. HPR is the most hydrophilic of the MacroSep BIO-Gold phases. MacroSep BIO-Gold HPR consists of unique perfluorinated aliphatic bonded groups which are highly hydrophilic and reduce the hydrophobic interaction of the stationary phase resulting in less retention of hydrophobic biological molecules with better recoveries and faster separations.
The MacroSep® BIO-Gold Diphenyl has the lowest bonding density and one of the lowest hydrophobicities of any BIO-Gold phenyl phases. It provides some site-specific phenyl interactions dependant on the molecular configuration of the target and can resolve many classes of proteins and bio-polymers. The MacroSep Bio-Gold has a unique phenyl ring configuration and may provide some site-specific interactions and a variety of solute interactions including π-π and hydrophobic going well beyond the simple hydrophobic interaction of MacroSep BIO-Gold alkyl phases. BIO-Gold Diphenyl is designed for bio-pharmaceutical and bio-chemical applications.
MacroSep® BIO-Gold C4 is the least hydrophobic of all the alkyl MacroSep BIO phases (C18 & C8) and can be used with highly aqueous mobile phases. These columns are designed for bio-pharmaceutical and bio-chemical applications. They are ideal for the separation of high molecular weight peptides, may be used to reduce analysis times, and provide enhanced stability under high aqueous mobile phase conditions.
MacroSep® BIO-Gold C18 takes bio selectivity to the next level of selective separation performance by utilizing ultra-high purity silica and state-of-the-art bonding technology. This hydrophobic phase is designed for bio-pharmaceutical and bio-chemical applications and is ideal for the separation of proteins, high molecular weight peptides and oligonucleic acids. It is specifically engineered to deliver high recoveries and excellent peak shapes for even the most difficult separations.
MacroSep® BIO-Gold Biphenyl is based upon bonded biphenyl groups with a high bonding density and is suitable for variety of solute interactions including π-π and hydrophobic. It is less hydrophobic than the BIO-Gold Naphthyl. MacroSep BIO-Gold Biphenyl is designed for bio-pharmaceutical and bio-chemical applications.
MacroSep® BIO-Gold PFP exhibits the strongest π-π interaction of all the BIO-Gold phases. The most hydrophilic of the BIO-Gold phenyl phases and may be used for fluorine modified biologics based upon a fluorophilicity interaction. Fluorinated phases such as pentafluorophenyl (PFP) with the highest π-π interaction of any the MacroSep BIO series stationary phases are of great importance in HPLC because their selectivity is orthogonal to the selectivity of traditional alkyl phases (C18, C8, C4 etc.). In addition, it may be useful for fluorine modified biologics based upon a fluorophilicity interaction.
MacroSep® BIO-Gold Naphthyl is based upon bonded planar naphthalene groups and has the highest bonding density and surface coverage of all the MacroSep Bio-Gold phases, providing maximum hydrophobic interaction and superior inertness. It is suitable for variety of solute interactions including π-π and hydrophobic. Ideal for the separation of high MW peptides and oligonucleic acids.
MacroSep® BIO-Gold HPR significantly reduces the hydrophobic interaction of the stationary phase. This reduced interaction can yield less retention of hydrophobic biological molecules, yielding better recoveries and quicker separations. HPR is the most hydrophilic of the MacroSep BIO-Gold phases. MacroSep BIO-Gold HPR consists of unique perfluorinated aliphatic bonded groups which are highly hydrophilic and reduce the hydrophobic interaction of the stationary phase resulting in less retention of hydrophobic biological molecules with better recoveries and faster separations.
The MacroSep® BIO-Gold Diphenyl has the lowest bonding density and one of the lowest hydrophobicities of any BIO-Gold phenyl phases. It provides some site-specific phenyl interactions dependant on the molecular configuration of the target and can resolve many classes of proteins and bio-polymers. The MacroSep Bio-Gold has a unique phenyl ring configuration and may provide some site-specific interactions and a variety of solute interactions including π-π and hydrophobic going well beyond the simple hydrophobic interaction of MacroSep BIO-Gold alkyl phases. BIO-Gold Diphenyl is designed for bio-pharmaceutical and bio-chemical applications.
MacroSep® BIO-Gold C8 is less hydrophobic and may yield faster separations when compared to C18. It is used to separate many classes of compounds including bio-pharmaceuticals and biologicals and is ideal for the separation of hydrophobic proteins and high molecular weight peptides. As with MacroSep BIO-Gold C18 columns, MacroSep BIO-Gold C8 columns are specifically engineered to deliver high recoveries and excellent peak shapes for even the most difficult separations and for a variety of biological molecules.
MacroSep® BIO-Gold C4 is the least hydrophobic of all the alkyl MacroSep BIO phases (C18 & C8) and can be used with highly aqueous mobile phases. These columns are designed for bio-pharmaceutical and bio-chemical applications. They are ideal for the separation of high molecular weight peptides, may be used to reduce analysis times, and provide enhanced stability under high aqueous mobile phase conditions.
MacroSep® BIO-Gold C18 takes bio selectivity to the next level of selective separation performance by utilizing ultra-high purity silica and state-of-the-art bonding technology. This hydrophobic phase is designed for bio-pharmaceutical and bio-chemical applications and is ideal for the separation of proteins, high molecular weight peptides and oligonucleic acids. It is specifically engineered to deliver high recoveries and excellent peak shapes for even the most difficult separations.
MacroSep® BIO-Gold Biphenyl is based upon bonded biphenyl groups with a high bonding density and is suitable for variety of solute interactions including π-π and hydrophobic. It is less hydrophobic than the BIO-Gold Naphthyl. MacroSep BIO-Gold Biphenyl is designed for bio-pharmaceutical and bio-chemical applications.
MacroSep® BIO-Gold PFP exhibits the strongest π-π interaction of all the BIO-Gold phases. The most hydrophilic of the BIO-Gold phenyl phases and may be used for fluorine modified biologics based upon a fluorophilicity interaction. Fluorinated phases such as pentafluorophenyl (PFP) with the highest π-π interaction of any the MacroSep BIO series stationary phases are of great importance in HPLC because their selectivity is orthogonal to the selectivity of traditional alkyl phases (C18, C8, C4 etc.). In addition, it may be useful for fluorine modified biologics based upon a fluorophilicity interaction.
MacroSep® BIO-Gold Naphthyl is based upon bonded planar naphthalene groups and has the highest bonding density and surface coverage of all the MacroSep Bio-Gold phases, providing maximum hydrophobic interaction and superior inertness. It is suitable for variety of solute interactions including π-π and hydrophobic. Ideal for the separation of high MW peptides and oligonucleic acids.
MacroSep® BIO-Gold HPR significantly reduces the hydrophobic interaction of the stationary phase. This reduced interaction can yield less retention of hydrophobic biological molecules, yielding better recoveries and quicker separations. HPR is the most hydrophilic of the MacroSep BIO-Gold phases. MacroSep BIO-Gold HPR consists of unique perfluorinated aliphatic bonded groups which are highly hydrophilic and reduce the hydrophobic interaction of the stationary phase resulting in less retention of hydrophobic biological molecules with better recoveries and faster separations.
The MacroSep® BIO-Gold Diphenyl has the lowest bonding density and one of the lowest hydrophobicities of any BIO-Gold phenyl phases. It provides some site-specific phenyl interactions dependant on the molecular configuration of the target and can resolve many classes of proteins and bio-polymers. The MacroSep Bio-Gold has a unique phenyl ring configuration and may provide some site-specific interactions and a variety of solute interactions including π-π and hydrophobic going well beyond the simple hydrophobic interaction of MacroSep BIO-Gold alkyl phases. BIO-Gold Diphenyl is designed for bio-pharmaceutical and bio-chemical applications.
MacroSep® BIO-Gold C8 is less hydrophobic and may yield faster separations when compared to C18. It is used to separate many classes of compounds including bio-pharmaceuticals and biologicals and is ideal for the separation of hydrophobic proteins and high molecular weight peptides. As with MacroSep BIO-Gold C18 columns, MacroSep BIO-Gold C8 columns are specifically engineered to deliver high recoveries and excellent peak shapes for even the most difficult separations and for a variety of biological molecules.
MacroSep® BIO-Gold C4 is the least hydrophobic of all the alkyl MacroSep BIO phases (C18 & C8) and can be used with highly aqueous mobile phases. These columns are designed for bio-pharmaceutical and bio-chemical applications. They are ideal for the separation of high molecular weight peptides, may be used to reduce analysis times, and provide enhanced stability under high aqueous mobile phase conditions.
MacroSep® BIO-Gold C18 takes bio selectivity to the next level of selective separation performance by utilizing ultra-high purity silica and state-of-the-art bonding technology. This hydrophobic phase is designed for bio-pharmaceutical and bio-chemical applications and is ideal for the separation of proteins, high molecular weight peptides and oligonucleic acids. It is specifically engineered to deliver high recoveries and excellent peak shapes for even the most difficult separations.
MacroSep® BIO-Gold Biphenyl is based upon bonded biphenyl groups with a high bonding density and is suitable for variety of solute interactions including π-π and hydrophobic. It is less hydrophobic than the BIO-Gold Naphthyl. MacroSep BIO-Gold Biphenyl is designed for bio-pharmaceutical and bio-chemical applications.
MacroSep® BIO-Gold PFP exhibits the strongest π-π interaction of all the BIO-Gold phases. The most hydrophilic of the BIO-Gold phenyl phases and may be used for fluorine modified biologics based upon a fluorophilicity interaction. Fluorinated phases such as pentafluorophenyl (PFP) with the highest π-π interaction of any the MacroSep BIO series stationary phases are of great importance in HPLC because their selectivity is orthogonal to the selectivity of traditional alkyl phases (C18, C8, C4 etc.). In addition, it may be useful for fluorine modified biologics based upon a fluorophilicity interaction.
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