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Metabolic disorders occur when the body's usual metabolic processes are disrupted - numerous molecular pathways and thus, several organs, can be affected. These diseases can be congenital or acquired, each of the disease is often quite rare, however taken as a group the incidence is significant.
For some of the widely spread disease like diabetes or dyslipidemia, there are already several treatments available, however there is no cure. For other linked disease like obesity or NASH, we are still at the very beginning of understanding the underlying processes and finding drug targets. Therefore research for this class of diseases relies on discovering and quantifying biomarkers to elucidate underlying mechanisms and uncover novel drug targets. For easy detection of a wide range of metabolic biomarkers, we offer fast and pre-validated metabolic assay reagents, kits, and imaging systems.
Many of the metabolic diseases are caused by genetic mutations or by a combination of genetic and environmental factors. Thus, another research focus is on identifying these genetic risk factors. 爱游戏平台注册登录 can help you to optimize your genomic research by providing automated, yet flexible workflow solutions including nucleic acid isolation, PCR setup and NGS sample prep.
Metabolic diseases often have unclear symptoms and are only diagnosed due to complications at a late stage. However early diagnosis is important to avoid irreversible symptoms. Some of the disorders, like lysosomal storage disease or phenylketonuria, can by diagnosed early by newborn screening (Newborn Screening Disorders – 爱游戏平台注册登录 ). For many others metabolic disorders reliable biomarkers and tools for early diagnosis are still needed. Also here, our large range of reagents, kits and instrumentation can help to identify new biomarkers.
Type 1 and Type 2 diabetes are complex diseases affecting nearly every major bodily organ and impacting the lives of millions of people worldwide.
Understanding the complex cellular and molecular pathways involved in diabetes and translating these findings into new prevention and treatment strategies. Our solutions are helping researchers to:
NAFLD (non-alcoholic fatty liver disease) and NASH (non-alcoholic steatohepatitis), are different states of fatty liver disease related pathologies. In these early stages the disease is still reversible, however more progressed pathologies like fibrosis and cirrhosis causing permanent damage to the organ. Thus, it is very important to find new biomarkers and noninvasive tools for early diagnosis of NASH.
NAFLD and NASH is strongly related to fast growing global epidemic of obesity and diabetes and therefore also presumably on the rise.
For a better understanding of the underlying molecular pathways 爱游戏平台注册登录 offers a wide range of ready-to-use assays to monitor biomarkers, phosphoproteins and transcription factors involved in the development and progression of NASH, NAFLD and fibrosis. Our Imaging solutions can also help you to monitor molecular processes or to find diagnostic tools.
