Nonalcoholic fatty liver disease (NAFLD) is a silent disease, characterized by fat accumulation in the liver that's not caused by alcohol. NAFLD can progress to nonalcoholic steatohepatitis (NASH), with inflammation and damage to liver cells. It displays few symptoms and there's little understanding of its pathogenesis. By the time individuals with NASH become aware of symptoms, it can be too late to reverse.
There are currently no approved treatments for these, and NAFLD or NASH diagnosis remains challenging. But studies show that fat and scar tissue can leave the liver, suggesting that NAFLD and NASH are reversible.
