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Operetta CLS High Content Analysis System

Operetta^® CLS^™ is a high throughput microplate imager for high-content analysis (HCA). It can acquire, analyze and manage fluorescence, brightfield and digital phase contrast images. The combination of high power LED excitation with fast, precise mechanics and one large format sCMOS camera enables fast imaging. Controlled by Harmony^™ software it offers a seamless workflow, for reliable discrimination of phenotypes even in complex cellular models.

To view our library of resources, images, and videos, visit the Resources and Image/Video Gallery sections below.

Features at a Glance

Intelligent image acquisition

Target more accurately your object of interest for significantly reduced acquisition and analysis times, particularly valuable for 3D microtissue and rare event studies.

Machine learning

Easily create algorithms without being an image analysis expert using our PhenoLOGIC proprietary machine-learning technology.

Easily quantify cellular phenotypes in complex 3D models

Explore your cell models by visualizing them in a 3D- and an XYZ-viewer and quantify volumetric and other 3D related phenotypic readouts.

Powerfully simple analysis capabilities

Harmony^® high-content imaging and analysis software - is the easy-to-learn, easy-to-use software that can make you more productive - faster.

High efficiency excitation design

Direct coupling limits the light loss that is typical of light guides or fibers.

Fast Frame Rate Imaging

Capture rapid cellular changes with an imaging frame rate up to 105 fps.

Automated water-immersion objectives

From the company with more than 20 years of experience - giving faster exposure times, increased resolution and reduced photodamage.

Confocal spinning-disk technology

Provides a gentle imaging process (especially for live-cell experiments) with efficient background rejection.

Customer Testimonials

Dr. Davide Danovi
Centre for Stem Cells & Regenerative Medicine
King's College London

Univ. Prof. Dr. Doris Wilflingseder
Institute of Hygiene and Medical Microbiology
Medical University of Innsbruck

A Solution Configured to Suit Every Need

Whatever your application, there’s an Operetta CLS system configured to meet your requirements. And it’s modular, so it can change with your research demands.

Operetta CLS Configurations

Operetta^® CLS^™ Quattro

Ideal for common applications that need sensitivity and resolution, with the capacity to grow if the need arises.

Operetta^® CLS^™ FLEX

Offers flexibility in excitation and imaging modes for many challenging applications – and it can be upgraded to even higher performance.

Operetta^® CLS^™ LIVE

Ideal for gentle yet highly sensitive live-cell imaging.

		Quattro	FLEX	LIVE
System Options	Camera	sCMOS	sCMOS	sCMOS
	Number of LEDs	4	8	8
	Confocal Disk	º	•	•
	Environmental Control	º	º	•
	Water Immersion	º	º	•
	Transmitted Light	•	•	•
	Robotics/Automation Compatible	•	•	•
Imaging Modes	Fluorescence Widefield Imaging	•	•	•
	Confocal Flourescence	º	•	•
	Brightfield and Digital Phase Contrast	•	•	•
	Ratiometric FRET	•	•	•
	3D Imaging	º	•	•
	Live-Cell Imaging	º	º	•
• Includedº Optional

Image/Video Gallery

Resources

This guide provides instructions on how to find help and manuals for your HCS Hardware/Software (Opera Phenix Plus, Operetta CLS, Harmony).

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analysis-of-mitochondrial-dynamics-in-human-ipsc-derived-neurons-512x288.jpg

Mitochondrial dynamics are essential for energy conversion and neuron survival. Understanding changes in mitochondrial dynamics is therefore crucial in developi ...

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The product of more than a decade of experience in high-content screening, the Operetta CLS delivers the speed and sensitivity for everyday assays, and even com ...

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Phenotypic Drug Discovery Re-Imagined Cell Painting is a phenotypic screening method and a powerful application of high-content screening technology which combi ...

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細胞外信號調節激酶(ERK)是胚胎形成、細胞分化、細胞增殖與細胞死亡的關鍵調節成分。ERK信號通路依癌細胞類型的變化而變化，經常作為治療性幹預的靶標而被研究。該應用文獻描述如何利用Operetta CLS™高內涵分析係統開展研究ERK信號的活細胞FRET試驗。基於FRET的生物傳感器的優化設計、Operetta CLS ...

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高內涵篩選的優勢在於通過從細胞中提取盡可能多的相關信息來加速藥物研發的過程。大部分高內涵篩選僅分析少量基於圖像的屬性，導致從細胞和疾病模型中獲得的有價值的信息未被充分利用。為促進細胞分割，幾乎所有篩選方法均要求細胞核染色（如Hoechst），因此細胞核表型分析可為試驗提供新角度，同時還不會產生額外成本。

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Publications in which 爱游戏平台注册登录 high-content analysis and screening systems are used number more than 1000 between 2010 and 2019. Here we feature some of the ...

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無論是希望利用高通量篩選探索複雜3D細胞模型的生理相關性，還是希望升級3D細胞模型分析（從簡單的酶標儀升級為高內涵），均需要使用正確的工具與策略才能克服模型造成的難題。

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多細胞3D“oids”（囊腫樣、球狀體、細胞器）能夠更好地在臨床前篩選中預測候選藥物的影響，但相比於使用2D細胞單層，使用3D模型係統的試驗更難以開展。本技術說明描述如何利用高內涵篩選係統以及成像和分析軟件對球狀體進行3D成像與分析。本技術說明描述：如何縮短圖像采集時間與數據量如何從3D角度分析全部與部分球狀體 ...

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高內涵成像中的關鍵參數（速度、靈敏度（或光強度）與分辨率）無法單獨優化，因為改變其中任何一個參數均會影響其它參數。例如，通過選擇較大的放大倍率提高分辨率時，為保持細胞量不變，需提高成像視野數，但這會降低速度；或通過延長曝光時間提高熒光強度時，速度也會下降。這些問題可以克服。本技術說明解釋了正確選擇物鏡的重要原因。

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In this webinar, learn how high-content screening enables high-throughput imaging and analysis of mitochondrial networks.

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This webinar will describe the marriage of 3D organoids and high-content screening (HCS) to discover targeted drug therapies effective against the malignant phe ...

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