Targeted in vivo agents on the ASK

 

Products (List of agents)

2-DG probe

NIR targeted probe for non-invasive imaging of glucose uptake of tumors in vivo.

Annexin-Vivo™

In vivo targeting of membrane-bound phosphatidylserine exposed during the early stages of apoptosis.

BacteriSense™

Fast-clearing, targeted probe which binds to negatively charged lipids on the bacterial cell membrane, enabling the monitoring of infection progression in real time.

Bacterial Detection Probe

NIR targeted probe for non-invasive detection of bacterial infections in vivo.

BombesinRSense

NIR targeted probe specific to bombesin receptors, which are expressed in many types of cancers.

COX-2 probe

Imaging probe that specifically detects cyclooxygenase-2 (COX-2), produced in early-stage cancer cells.

FolateRSense™

Highly specific and sensitive in detection of Folate Receptor protein.  Can be used to closely monitor and quantitate tumor growth and metabolism.

GFR-Vivo Agent

Near infrared (NIR) fluorescent-labeled form of inulin. Enables assessment of Glomerular filtration rate (GFR) by measurement of the rate of disappearance of labeled inulin from the blood.

HypoxiSense™

Fluorescent imaging agent that detects the tumor cell surface expression of carbonic anhydrase 9 (CA IX) protein, which increases in hypoxic regions within many tumors, especially in cervical, colorectal, non-small cell lung tumors.

IntegriSense™

Potent antagonist targeting integrin αγβ3, expressed in oncology, atherosclerosis and angiogensis disease models.  Small molecule fluorochrome to label target ligand.  

OsteoSense™

Fluorescent in vivo bisphosphonate imaging agent that targets areas of micro-calcifications and bone remodeling and enables imaging of bone growth and resorption.

TLectinSense™

Near-infrared dye-labeled macromolecule that targets the vasculature and enables imaging of blood vessels and angiogenesis.

Transferrin-Vivo

Near infrared (NIR) targeted fluorescent imaging agent consisting of recombinant transferrin conjugated to VivoTag dye, designed to bind to transferrin receptors expressed in cancer cells.