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535.8887 40.0047 536.6583 39.6121 536.8278 38.5677 c f 538.1478 36.1375 0.6038 5.8726 re f 543.295 40.3797 m 543.9482 40.3797 l 541.6487 35.3464 l 541.3398 34.6785 541.0787 34.491 540.4083 34.491 c 540.2208 34.491 540.0093 34.491 539.8278 34.5056 c 539.8278 35.0125 l 539.9583 35.0037 540.0985 34.9963 540.2612 34.9963 c 540.6932 34.9963 540.9048 35.0945 541.102 35.5178 c 541.378 36.1053 l 539.3155 40.3797 l 539.9688 40.3797 l 541.6968 36.8479 l f 543.7053 36.1375 0.699 0.898 re f 489.8517 85.4225 m 489.8517 85.046 l 492.7053 83.0136 494.5685 79.8964 494.5685 76.1266 c 494.5685 72.3568 492.7053 69.132 489.8517 67.1002 c 489.8517 66.8373 l 505.6391 74.7138 l f 479.9021 58.1636 m 471.2771 58.1636 l 474.7283 85.3797 l 483.3533 85.3797 l f 0 0 0 1 k 549.2065 53.2425 m 549.472 53.2425 l 549.6978 53.2425 549.904 53.2534 549.904 53.5123 c 549.904 53.7299 549.7165 53.7636 549.544 53.7636 c 549.2065 53.7636 l 549.2065 53.2425 l h 548.9507 53.9698 m 549.5853 53.9698 l 549.9745 53.9698 550.159 53.8159 550.159 53.501 c 550.159 53.2048 549.9715 53.0809 549.727 53.055 c 550.1957 52.3309 l 549.922 52.3309 l 549.4765 53.0359 l 549.2065 53.0359 l 549.2065 52.3309 l 548.9507 52.3309 l 548.9507 53.9698 l h 549.499 51.9523 m 550.1478 51.9523 550.6503 52.4698 550.6503 53.156 c 550.6503 53.8273 550.1478 54.3448 549.499 54.3448 c 548.8428 54.3448 548.3403 53.8273 548.3403 53.156 c 548.3403 52.4698 548.8428 51.9523 549.499 51.9523 c h 549.499 54.5509 m 550.2632 54.5509 550.9053 53.9474 550.9053 53.156 c 550.9053 52.35 550.2632 51.7461 549.499 51.7461 c 548.7295 51.7461 548.0853 52.35 548.0853 53.156 c 548.0853 53.9474 548.7295 54.5509 549.499 54.5509 c f Q Q /GS1 gs q BT /F0 1 Tf 9.5 0 0 9.5 54 602.0986 Tm 0 0 0 1 k (U)Tj ET Q /GS2 gs /GS1 gs q BT /F1 1 Tf 9.5 0 0 9.5 61.561 602.0986 Tm 0 0 0 1 k (Light)Tj ET Q /GS2 gs /GS1 gs q BT /F0 1 Tf 9.5 0 0 9.5 86.5355 602.0986 Tm 0 0 0 1 k (\252-Histone H3 (Thr3/Ser10) Peptide:)Tj -3.42479 -1.78947 TD [-763(TRF0125-D: 0.5 nmole, 1,000* assay points)]TJ 0 -1.68421 TD [-763(TRF0125-M: 5 nmoles, 10,000* assay points)]TJ ET Q /GS2 gs /GS1 gs q BT /F2 1 Tf 9 0 0 9 54 554.0986 Tm 0 0 0 1 k (*0.5 pmol/assay point )Tj ET Q /GS2 gs /GS1 gs q BT /F3 1 Tf 9 0 0 9 54 535.0985 Tm 0 0 0 1 k (PEPTIDE SEQUENCE:)Tj ET Q /GS2 gs /GS1 gs q BT /F4 1 Tf 9 0 0 9 54 523.0985 Tm 0 0 0 1 k (AR)Tj ET Q /GS2 gs /GS1 gs q BT /F3 1 Tf 9 0 0 9 65.6719 523.0985 Tm 0 0 0 1 k (T)Tj ET 0.45 w 0 0 0 1 K 65.6719 522.1985 m 71.0069 522.1985 l S Q /GS2 gs /GS1 gs q BT /F4 1 Tf 9 0 0 9 71.0068 523.0985 Tm 0 0 0 1 k [(KQT)68(ARK)]TJ ET Q /GS2 gs /GS1 gs q BT /F3 1 Tf 9 0 0 9 105.4028 523.0985 Tm 0 0 0 1 k (S)Tj ET 0.45 w 0 0 0 1 K 105.4028 522.1985 m 111.2343 522.1985 l S Q /GS2 gs /GS1 gs q BT /F4 1 Tf 9 0 0 9 111.2344 523.0985 Tm 0 0 0 1 k (TGGKAPRKQLAGCG)Tj -6.35938 -2.11111 TD [(Synthetic peptide containing the r)18(esidues surr)17(ounding Thr3)]TJ 0 -1.33333 TD -0.017 Tc [(a)-17(n)-17(d)-17( )-17(Ser10 of human Histone H3; phosphorylation site: Thr3)]TJ 0 -1.33334 TD (and Ser10.)Tj ET Q /GS2 gs /GS1 gs q BT /F3 1 Tf 9 0 0 9 54 461.0986 Tm 0 0 0 1 k [(V)55(ALIDA)92(TED FOR KINASE:)]TJ ET Q /GS2 gs /GS1 gs q BT /F4 1 Tf 9 0 0 9 163.0217 461.0986 Tm 0 0 0 1 k [(Aur)18(ora B, CRIK, MRCK)]TJ ET Q /GS2 gs /GS1 gs q BT /F5 1 Tf 9 0 0 9 253.0393 461.0986 Tm 0 0 0 1 k (a)Tj ET Q /GS2 gs /GS1 gs q BT /F4 1 Tf 9 0 0 9 258.5369 461.0986 Tm 0 0 0 1 k (,)Tj -22.72632 -1.33333 TD (WNK2, WNK3.)Tj ET /CS0 cs 1 scn 551.52 395.784 24.48 378.216 re f Q /GS2 gs /GS1 gs q BT /F0 1 Tf 25 0 0 25 54 700.8543 Tm 0 0 0 1 k (Aurora B Kinase Assay)Tj ET Q /GS2 gs /GS1 gs q BT /F0 1 Tf 17 0 0 17 54 672.8542 Tm 0 0 0 1 k (U)Tj ET Q /GS2 gs /GS1 gs q BT /F1 1 Tf 17 0 0 17 67.5303 672.8542 Tm 0 0 0 1 k (Light)Tj ET Q /GS2 gs /GS1 gs q BT /F0 1 Tf 17 0 0 17 110.9724 672.8542 Tm 0 0 0 1 k (-Histone H3 (Thr3/Ser10) Peptide &)Tj -3.35132 -1.23529 TD -0.013 Tc (Europium-anti-phospho-Histone H3 (Ser10) Antibody)Tj ET Q /GS2 gs q BT /F6 1 Tf 0 -10 10 0 559.3173 759.8959 Tm 0 0 0 0 k 0.9449 Tc (T)Tj 1.55593 0 TD (E)Tj 1.59293 0 TD (C)Tj 1.68593 0 TD (H)Tj 1.68593 0 TD (N)Tj 1.68593 0 TD (I)Tj 1.23993 0 TD (C)Tj 1.68593 0 TD (A)Tj 1.62993 0 TD (L)Tj 2.76087 0 TD (N)Tj 1.68593 0 TD (O)Tj 1.72293 0 TD (T)Tj 1.55593 0 TD (E)Tj ET Q /GS1 gs q BT /F3 1 Tf 0 -10 10 0 534.6686 760.8959 Tm /CS0 cs 1 scn 0.1389 Tc (L)Tj 0.71289 0 TD (A)Tj 0.80589 0 TD (N)Tj 0.86089 0 TD (C)Tj 0.86089 0 TD (E)Tj ET Q /GS2 gs /GS1 gs q BT /F7 1 Tf 0 -10 10 0 534.6686 716.6321 Tm /CS0 cs 1 scn 0.1389 Tc (U)Tj 0.87992 0 TD (L)Tj 0.63901 0 TD 0.1387 Tc (T)Tj 0.7317 0 TD (R)Tj 0.8427 0 TD (A)Tj ET 0 0 0 0 k 54 34.1989 184.98 17.999 re f Q /GS2 gs /GS1 gs q BT /F6 1 Tf 10 0 0 10 54 45.0598 Tm /CS0 cs 1 scn 0.111 Tc [(www)55(.perkinelmer)92(.com)]TJ ET Q /GS2 gs /GS1 gs q BT /F0 1 Tf 9.5 0 0 9.5 303 602.0986 Tm 0 0 0 1 k (Europium-anti-phospho-Histone H3 (Ser10))Tj 0 -1.47368 TD (Antibody:)Tj 0 -1.78948 TD [-763(TRF0210-D: 10 \265g, 1,562* assay points)]TJ 0 -1.68421 TD [-763(TRF0210-M: 100 \265g, 15,625* assay points)]TJ ET Q /GS2 gs /GS1 gs q BT /F2 1 Tf 9 0 0 9 303 540.0986 Tm 0 0 0 1 k (*40 fmol/assay point)Tj ET Q /GS2 gs /GS1 gs q BT /F3 1 Tf 9 0 0 9 303 521.0986 Tm 0 0 0 1 k (RECOGNIZED MOTIF: )Tj ET Q /GS2 gs /GS1 gs q BT /F4 1 Tf 9 0 0 9 303 509.0986 Tm 0 0 0 1 k [(TKQT)68(ARKp)]TJ ET Q /GS2 gs /GS1 gs q BT /F3 1 Tf 9 0 0 9 347.5649 509.0986 Tm 0 0 0 1 k (S)Tj ET 0.45 w 0 0 0 1 K 347.5649 508.1986 m 353.3965 508.1986 l S Q /GS2 gs /GS1 gs q BT /F4 1 Tf 9 0 0 9 353.3965 509.0986 Tm 0 0 0 1 k (TGGKAPR)Tj -5.59961 -2.11112 TD [(Eur)18(opium-labeled mouse monoclonal antibody r)17(ecognizing)]TJ 0 -1.33333 TD (phospho-Ser10 in human Histone H3.)Tj ET /GS2 gs q 54.125 133.409 233.113 290.651 re W n q 222.65331 0 0 290.66751 62.757 133.2674 cm /Im1 Do Q Q /GS1 gs 0.25 w 0 0 0 1 K 54.125 133.409 233.113 290.651 re s Q /GS2 gs /GS1 gs q BT /F8 1 Tf 9.5 0 0 9.5 54 621.1196 Tm /CS0 cs 1 scn [(T)74(wo LANCE )]TJ ET Q /GS2 gs /GS1 gs q BT /F9 1 Tf 9.5 0 0 9.5 124.1854 621.1196 Tm /CS0 cs 1 scn (Ultra)Tj ET Q /GS2 gs /GS1 gs q BT /F8 1 Tf 9.5 0 0 9.5 154.9584 621.1196 Tm /CS0 cs 1 scn (companion products \320 two convenient sizes!)Tj 15.58333 -21.4558 TD (LANCE )Tj ET Q /GS2 gs /GS1 gs q BT /F9 1 Tf 9.5 0 0 9.5 346.0956 417.2895 Tm /CS0 cs 1 scn (Ultra)Tj ET Q /GS2 gs /GS1 gs q BT /F8 1 Tf 9.5 0 0 9.5 376.8685 417.2895 Tm /CS0 cs 1 scn (Kinase Assays)Tj ET Q /GS2 gs /GS1 gs q BT /F4 1 Tf 9 0 0 9 303 401.2895 Tm 0 0 0 1 k (LANCE)Tj ET Q /GS2 gs /GS1 gs q BT /F10 1 Tf 5.5 0 0 5.5 331.5051 405.2895 Tm 0 0 0 1 k Tj ET Q /GS2 gs /GS1 gs q BT /F2 1 Tf 9 0 0 9 338.3128 401.2895 Tm 0 0 0 1 k (Ultra)Tj ET Q /GS2 gs /GS1 gs q BT /F4 1 Tf 9 0 0 9 358.9781 401.2895 Tm 0 0 0 1 k [(time-r)18(esolved fluor)17(escence r)18(esonance energy)]TJ -6.21979 -1.33333 TD -0.011 Tc [(transfer (TR-FRET) assays use a pr)18(oprietary eur)17(opium chelate)]TJ T* 0 Tc (donor dye, W-1024 (Eu), with U)Tj ET Q /GS2 gs /GS1 gs q BT /F2 1 Tf 9 0 0 9 425.3415 377.2895 Tm 0 0 0 1 k (Light)Tj ET Q /GS2 gs /GS1 gs q BT /F4 1 Tf 9 0 0 9 444.3347 377.2895 Tm 0 0 0 1 k -0.0002 Tc (,)Tj 0.55567 0 Td 0 Tc (an innovative small)Tj -16.25952 -1.33334 TD [(molecular weight acceptor dye with a r)18(ed-shifted fluor)17(escent)]TJ 0 -1.33333 TD (emission. In kinase assays, the binding of a Eu-labeled anti-)Tj T* (phospho-substrate antibody to the phosphorylated U)Tj ET Q /GS2 gs /GS1 gs q BT /F2 1 Tf 9 0 0 9 508.7981 341.2895 Tm 0 0 0 1 k (Light)Tj ET Q /GS2 gs /GS1 gs q BT /F4 1 Tf 9 0 0 9 527.7913 341.2895 Tm 0 0 0 1 k (-)Tj -24.97681 -1.33333 TD (labeled substrate brings donor and acceptor molecules into)Tj T* (close pr)Tj 3.4082 0 TD [(oximity)92(. )]TJ -3.4082 -2.11112 TD [(After irradiation of the kinase r)18(eaction at 320 or 340 nm, the)]TJ 0 -1.33333 TD -0.017 Tc [(energy fr)18(om the Eu donor is transferr)17(ed to the U)]TJ ET Q /GS2 gs /GS1 gs q BT /F2 1 Tf 9 0 0 9 480.7991 286.2895 Tm 0 0 0 1 k -0.017 Tc (Light)Tj ET Q /GS2 gs /GS1 gs q BT /F4 1 Tf 9 0 0 9 501.3922 286.2895 Tm 0 0 0 1 k -0.017 Tc (acceptor)Tj -22.04358 -1.33333 TD 0 Tc (dye which, in tur)Tj 7.07251 0.00001 TD (n, generates light at 665 nm. The intensity )Tj -7.07251 -1.33334 TD 0.017 Tc [(of the light emission is pr)18(oportional to the level of U)]TJ ET Q /GS2 gs /GS1 gs q BT /F2 1 Tf 9 0 0 9 508.0528 262.2895 Tm 0 0 0 1 k 0.017 Tc (Light)Tj ET Q /GS2 gs /GS1 gs q BT /F4 1 Tf 9 0 0 9 527.7964 262.2895 Tm 0 0 0 1 k (-)Tj -24.97738 -1.33333 TD (substrate phosphorylation.)Tj ET Q /GS2 gs /GS1 gs q BT /F8 1 Tf 9.5 0 0 9.5 303 228.2895 Tm /CS0 cs 1 scn (Development of Aurora B Kinase Assay)Tj ET Q /GS2 gs /GS1 gs q BT /F0 1 Tf 9.5 0 0 9.5 303 210.2895 Tm 0 0 0 1 k (Additional reagents)Tj ET Q /GS2 gs /GS1 gs q BT /F4 1 Tf 9 0 0 9 303 196.2895 Tm 0 0 0 1 k (Aur)Tj 1.46387 0.00001 TD [(ora B active)-7521(Car)-18(na # 05-102)]TJ -1.46387 -1.55557 TD (LANCE Detection Buf)Tj 9.27832 -0.00001 TD [(fer)92(, 10X)-1577(PerkinElmer #CR97-100)]TJ -9.27832 -1.55555 TD [(OptiPlate\252-384, white)-4293(PerkinElmer # 6007299)]TJ T* [(T)111(opSeal\252 -A)-8403(PerkinElmer # 6005185)]TJ 0 -1.55556 TD [(Kinase Buf)18(fer: 50 mM HEPES pH 7.5, 1 mM EGT)67(A, )]TJ 0 -1.33333 TD (10 mM MgCl)Tj ET Q /GS2 gs /GS1 gs q BT /F4 1 Tf 5.94 0 0 5.94 353.4932 125.3195 Tm 0 0 0 1 k (2)Tj ET Q /GS2 gs /GS1 gs q BT /F4 1 Tf 9 0 0 9 356.7953 128.2894 Tm 0 0 0 1 k -0.0001 Tc (,)Tj 0.5557 0 Td (2)Tj 0.83371 0 Td 0 Tc [(mM DTT and 0.01% T)111(ween-20)]TJ ET Q /GS2 gs /GS1 gs q BT /F3 1 Tf 11 0 0 11 54 736.1475 Tm /CS0 cs 1 scn (TECH NOTE )Tj ET Q /GS2 gs /GS1 gs q BT /F7 1 Tf 11 0 0 11 119.1916 736.1475 Tm /CS0 cs 1 scn (U)Tj ET Q /GS2 gs /GS1 gs q BT /F3 1 Tf 11 0 0 11 127.3423 736.1475 Tm /CS0 cs 1 scn (-TRF #22)Tj ET Q endstream endobj 9 0 obj << /BitsPerComponent 8 /ColorSpace/DeviceCMYK /Filter/FlateDecode /Height 444 /Subtype/Image /Type/XObject /Length 60244 /Width 826 >> stream X @TٝX(TBQT@ZŖRTpA@B\@T@N%&3/o2;MzL&KG3I$3L'=$W0RCU9NU{_2B!B!B!B!B!B!B!B!B!B!B!B!B!B!B!B!B!B!B!B!B!B!B!B!B!B!B!B!B!B!B!B!B!B!B!B!B!B!B!B!B!B!B!B!B!B!B!B!B!B!B!B!B!ḏp-.Kp8 JDDDE VZ*%--p@Ր8E999sss;7?}m.O<ϕd3-[VZ|yoo3FB!B-r[==ZPPfY#Io{) M9{ΊUn)<'\kkn>_We~<'{sv6`q!u: >|}. /0#..+ވ(88teLhj1xU2226)!B!Xf&&~fO kxGn EGkgyr_m' ӧL2e%'s;+g;qī>[O4ibvܺu뺛_Q."ӧOOBsUUUQNQQi)\ m>>V7OzuuV1}0Ocu#B!BәIttt¼u=5,_F91;2$ayoU1!ZՕ?J&B!`܄ҊSoXKNϑ;}=7ij:m? ì5<1UN6ypgUEfsw}58qCk|7U2IOO/Exxx&\FEDr=CGrrk^ cDXdf]II"D!BȨ'puPn5~EJ_)*\ۚ(eSgm6͟q)\kyu {pkΘ?s.<0ϩ|n޼yy*G2瘟#8X8qbTll!{l W['Ovhlao_ 8Ǐ?P?9V7n7-YT0iҤhfFRRK9F 0Ӫ"B!d35)}%2|R}m_Zj#alhqg؃Cs37m.yvw{^Xc/#RKHHՇ9UmͿ̼ҥKˬ\L/,??7J8)gGmm틆Wi8`o\5'7nfe˖!ɣzc4[ZZ!B!B |< I%|~vӶ.CL+iii%aaaxjQ.r/_<&?x3b~\.T#g̙KvsGuu9f͚1>Ճdl1#77ף껺EB!QOGhRR";o&M;O( w9AAA6x: yLLLF|8 it:s6Mn9g K 8縼.6g B!Lsq*++Sy)yyyM\ȝx!< BZƬ[|+-Xddd`(2>vќB!Q exqU~"eӦMDU?rrrj~dڵgvY#9P?wNJUUҤ5/RYel1⃍Q;::^C= GWB!LDžG,[jgֲ'=_º((g<`yn׶o)kgݺuGmQh &#죨 H鉊VZZAy-C} ~>|sDHoޅ !C3iiikuǏ1J}CCc8B!2-GM6oJCKuC1 :Jnu}̞+@s6l8΍+WC8 N1 vioo]\:>!U~__]]]o!OS3f,z^/@XdX9Bw9B!8f j6CyMY*Yh/!A =U6 /5/sVqy$!lIz ƺa}WUUgV:;; !/׹\3C!BYי23yfש$8s̚5+kʔ)񡡡pՃ2qD4IűS0Q5|q;}ZK2Nmfs%9=\sRfjs!2qpqTdڴip5<_xvT=TVq*:꼥\޿WSSSס T$222.;;{ ;/XhQg׽ 5<8_"4&-G j"A 9c\YLϡB!dTP]]}κ&V<: ׯou<߽{a{NnY^ 9gpg1to<쏥MGG)"t?=wƍsqb|?X->a̮S.2}:)s=9B!F^EqJ,??)T\/lD~jTTC{ȞcS]]yyg^jvttdB-,ixAکϊ̘1#Yn1|9p`,TqN" mq\~XfFڔܔ))"-%551jB$C9BE#А,\0WB+VC9#-[V~\.T `ΝSǼyV t=GDZ=%5~>$WcM?^Р9)Gώ7ugX|U.=;v04:^_ML9ڢͧA1 eFRzjg_~H/MІ[ B!Qv? ^1sRv-Ћ1$ymڗGrg͚5DEE'))i5Czv9V={v<[j\#""&ٰaC7r>54BCCj67`㆛{1A>'XKJI\_\1<]oeݴiөM@yf)~_qSiq34B!B#9Xg2226Z%KDx@߂>coA[}q89G( CAk}I|5_0<3S0C!Gs5dͧ / :;;T'oϱZZZ^߉C s-[/p.CzΉ'.H^̊ĐS͛သlz[;11qY^^ y\6vqeee#cW[>>Рnݺ}-*y4ݛZxf4~@ţ-(T[bK"'w[%kII8 B!m۶}\-mlQt ^vP?9|Ex… Y=tksVXBBBs#4ÇG 49]VR\?~9<9͚މ0!C!) xCZ[[_vn 6ggnq0!}~2Loqϵlٲ*Tr܋-WߋЬhc346>jRGvyo9r[(49톆#gss!2Z=[[[/ZKIUUgT'OW0Ga]]kϹUѽQQQlk_vY֮]ہАo'NKVcu8sPuq8.Bc>י2sޜ0 n犁s93%q)B9BŞ`ֵtVV!(:Djj/ϱdɒWUwn{Zs.hnYݑo?ohhSE6{R9W 92XauwOW9ӧOOEe>+5-aZᣟsϥ%8 B!d{@;X/5kVVxxx0B#-.Dh:B!&񮁱omr[Lǡ2-a_<9B!d$p8)RRSSS>>]yY>|sOݛ^قrRǕw[ܪЍB%KTz<+V'l>۱csW3}$4Qwm~f_#444}Xb|4z!$,,,t:Qϟ_>x^yɓ' '֋hF?ta?"a

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111.6695 c 535.8651 111.6695 536.3539 110.8836 536.4377 110.3543 c 535.9158 110.3543 l 535.752 110.9839 535.2573 111.2315 534.6086 111.2315 c 533.5547 111.2315 533.0596 110.5662 533.0596 109.7182 c 533.0596 108.8067 533.6093 108.2049 534.6086 108.2049 c 535.3789 108.2049 535.8079 108.6213 535.9437 109.1952 c f 537.0306 112.9695 m 537.5551 112.9695 l 537.5551 112.1912 l 537.0306 112.1912 l 537.0306 112.9695 l h 537.0306 111.5565 m 537.5551 111.5565 l 537.5551 107.8799 l 537.0306 107.8799 l f 541.082 110.4672 m 540.9475 111.0614 540.5815 111.2315 539.8158 111.2315 c 539.2665 111.2315 538.757 111.1108 538.757 110.6018 c 538.757 110.2196 539.002 110.1422 540.1207 109.9937 c 541.2445 109.8452 541.7112 109.6471 541.7112 108.9336 c 541.7112 108.2049 541.1184 107.7682 539.9659 107.7682 c 538.7992 107.7682 538.107 108.1491 538.107 109.0314 c 538.586 109.0314 l 538.677 108.4169 539.0261 108.2049 539.9659 108.2049 c 540.6946 108.2049 541.1886 108.3534 541.1886 108.9057 c 541.1886 109.2726 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548.6733 106.8909 c 549.0477 106.8909 549.2311 106.976 549.402 107.3429 c 549.6412 107.852 l 547.8537 111.5565 l 548.4198 111.5565 l 549.9175 108.4957 l f 551.6581 107.8799 0.6058 0.7782 re f 504.9851 150.5936 m 504.9851 150.2673 l 507.4582 148.5059 509.073 145.8043 509.073 142.5372 c 509.073 139.27 507.4582 136.4751 504.9851 134.7143 c 504.9851 134.4864 l 518.6675 141.3127 l f 496.3622 126.9692 m 488.8871 126.9692 l 491.8781 150.5565 l 499.3532 150.5565 l f 0 0 0 1 k 556.4259 122.7043 m 556.656 122.7043 l 556.8516 122.7043 557.0304 122.7137 557.0304 122.9381 c 557.0304 123.1267 556.8679 123.1559 556.7184 123.1559 c 556.4259 123.1559 l 556.4259 122.7043 l h 556.2042 123.3346 m 556.7542 123.3346 l 557.0915 123.3346 557.2514 123.2012 557.2514 122.9283 c 557.2514 122.6716 557.0889 122.5642 556.877 122.5417 c 557.2833 121.9142 l 557.046 121.9142 l 556.6599 122.5252 l 556.4259 122.5252 l 556.4259 121.9142 l 556.2042 121.9142 l 556.2042 123.3346 l h 556.6794 121.5861 m 557.2416 121.5861 557.6772 122.0346 557.6772 122.6293 c 557.6772 123.2111 557.2416 123.6596 556.6794 123.6596 c 556.1107 123.6596 555.6751 123.2111 555.6751 122.6293 c 555.6751 122.0346 556.1107 121.5861 556.6794 121.5861 c h 556.6794 123.8382 m 557.3417 123.8382 557.8981 123.3152 557.8981 122.6293 c 557.8981 121.9308 557.3417 121.4074 556.6794 121.4074 c 556.0125 121.4074 555.4541 121.9308 555.4541 122.6293 c 555.4541 123.3152 556.0125 123.8382 556.6794 123.8382 c f Q Q Q /GS1 gs q BT /F4 1 Tf 9 0 0 9 309 731.5752 Tm 0 0 0 1 k [-611(Cover the plate with a T)111(opSeal-A and incubate for 60 min at)]TJ 1.11111 -1.33333 TD (r)Tj 0.29712 0.00001 TD [(oom temperatur)18(e \(R)-6(T\).)]TJ -1.40823 -1.55556 TD -0.017 Tc [-628(Stop kinase r)18(eactions by adding 5 )-1(\265L of 40 mM EDT)68(A pr)18(epar)17(ed)]TJ 1.11111 -1.33333 TD -0.0002 Tc (i)Tj 0.18485 0.00001 TD (n)Tj 0.8147 0 Td 0 Tc [(1X Detection Buf)18(fer (Stop Solution). Leave for 5 min at R)-6(T)111(.)]TJ -2.11066 -1.55557 TD [-611(Add 5 \265L of Detection Mix \(Eu-anti-phospho-Histone H3)]TJ 1.11111 -1.33333 TD -0.0001 Tc (\()Tj 0.24086 0.00001 TD 0 Tc (Ser10\) antibody at a final concentration of 2 nM\).)Tj -1.35197 -1.55556 TD [-611(Cover with T)111(opSeal-A and incubate for 1 h at R)-6(T)111(. )]TJ 0 -1.55555 TD Tj 1.11111 0.00001 TD -0.017 Tc [(Remove T)111(opSeal-A and r)17(ead signal with the EnV)-6(ision)]TJ ET Q /GS2 gs /GS1 gs q BT /F10 1 Tf 5.5 0 0 5.5 515.8876 643.5751 Tm 0 0 0 1 k Tj ET Q /GS2 gs /GS1 gs q BT /F4 1 Tf 9 0 0 9 522.5452 639.5752 Tm 0 0 0 1 k -0.0169 Tc (M)Tj 0.81614 0.00001 TD -0.017 Tc (ultilabel)Tj -23.43228 -1.33334 TD 0 Tc (Reader in TR-FRET mode \(excitation at 320 nm & emission )Tj 0 -1.33333 TD (at 665 nm\).)Tj ET Q /GS2 gs /GS1 gs q BT /F3 1 Tf 9 0 0 9 309 596.5751 Tm 0 0 0 1 k (NOTE:)Tj ET Q /GS2 gs /GS1 gs q BT /F4 1 Tf 9 0 0 9 338.3401 596.5751 Tm 0 0 0 1 k [(Eu-labeled antibodies and EDT)68(A can be pr)17(emixed befor)18(e)]TJ -3.26001 -1.33333 TD -0.0168 Tc (u)Tj 0.52018 0.00001 TD -0.017 Tc (se as a 2X concentrated Stop Solution/Detection mix to minimize)Tj -0.52018 -1.33334 TD 0 Tc (the number of liquid handling steps. )Tj ET Q /GS2 gs /GS1 gs q BT /F0 1 Tf 9.5 0 0 9.5 36 731.1046 Tm 0 0 0 1 k (Suggested procedure)Tj ET Q /GS2 gs /GS1 gs q BT /F4 1 Tf 9 0 0 9 36 717.1046 Tm 0 0 0 1 k [-611(Dilute the Aur)18(ora B kinase, A)67(TP)153(, inhibitors and U)]TJ ET Q /GS2 gs /GS1 gs q BT /F2 1 Tf 9 0 0 9 231.0032 717.1046 Tm 0 0 0 1 k (Light)Tj ET Q /GS2 gs /GS1 gs q BT /F4 1 Tf 9 0 0 9 249.9963 717.1046 Tm 0 0 0 1 k (-Histone)Tj -22.66626 -1.33333 TD [(H3 (Thr3/Ser10) Peptide in Kinase Buf)18(fer)91(. )]TJ -1.11111 -1.55555 TD [-611(Pr)18(epar)17(e a 4X Detection Mix by diluting the Eu-anti-phospho-)]TJ 1.11111 -1.33333 TD (Histone H3 (Ser10) antibody to 8 nM in 1X LANCE Detection)Tj T* [(Buf)18(fer)91(.)]TJ -1.11111 -1.55555 TD [-611(Add to the wells of a white OptiPlate-384:)]TJ ET Q /GS2 gs /GS1 gs q BT /F4 1 Tf 9 0 0 9 48 639.1046 Tm 0 0 0 1 k Tj ET Q /GS2 gs /GS1 gs q BT /F4 1 Tf 9 0 0 9 58 639.1046 Tm 0 0 0 1 k -0.0003 Tc (5)Tj 0.83374 0.00001 TD 0 Tc [(\265L of Aur)18(ora B enzyme)]TJ ET Q /GS2 gs /GS1 gs q BT /F4 1 Tf 9 0 0 9 48 626.1046 Tm 0 0 0 1 k Tj ET Q /GS2 gs /GS1 gs q BT /F4 1 Tf 9 0 0 9 58 626.1046 Tm 0 0 0 1 k [(2.5 \265L of inhibitor or Kinase Buf)18(fer)]TJ ET Q /GS2 gs /GS1 gs q BT /F4 1 Tf 9 0 0 9 48 613.1046 Tm 0 0 0 1 k Tj ET Q /GS2 gs /GS1 gs q BT /F4 1 Tf 9 0 0 9 58 613.1046 Tm 0 0 0 1 k (2.5 \265L of U)Tj ET Q /GS2 gs /GS1 gs q BT /F2 1 Tf 9 0 0 9 101.1675 613.1046 Tm 0 0 0 1 k (Light)Tj ET Q /GS2 gs /GS1 gs q BT /F4 1 Tf 9 0 0 9 120.1606 613.1046 Tm 0 0 0 1 k [(-Histone H3 (Thr3/Ser10) Peptide/ A)68(TP)]TJ -6.90673 -1.33333 TD [(mix \(for A)68(TP titration, A)67(TP dilutions ar)18(e added separately in)]TJ T* [(Kinase Buf)18(fer\).)]TJ ET Q /GS2 gs /GS1 gs q BT /F11 1 Tf 6 0 0 6 36 84.8238 Tm 0 0 0 1 k (For a complete listing of our global of)Tj 17.43945 0.00001 TD (fices, visit www)Tj 7.36523 0.00001 TD (.perkinelmer)Tj 5.97755 0.00001 TD (.com/lasof)Tj 4.72167 0.00001 TD (fices)Tj ET Q /GS2 gs /GS1 gs q BT /F12 1 Tf 6 0 0 6 36 70.8238 Tm 0 0 0 1 k (\2512007 PerkinElmer)Tj 8.91407 0.00001 TD -0.0002 Tc (,)Tj 0.55567 0 Td 0 Tc (Inc. All rights r)Tj 6.99633 0.00001 TD (eser)Tj 1.83277 0.00001 TD [(ved. The PerkinElmer logo and design are registered trademarks of PerkinElmer)54(, Inc. OptiPlate, T)92(opSeal and U)]TJ ET Q /GS2 gs /GS1 gs q BT /F13 1 Tf 6 0 0 6 449.5093 70.8238 Tm 0 0 0 1 k (Light)Tj ET Q /GS2 gs /GS1 gs q BT /F12 1 Tf 6 0 0 6 465.063 70.8238 Tm 0 0 0 1 k (ar)Tj 0.88892 0.00001 TD -0.0001 Tc (e)Tj 0.77778 0 Td 0 Tc (trademarks and EnV)Tj 9.27618 0.00001 TD (ision, )Tj 2.83178 0.00001 TD -0.011 Tc (and)Tj -85.28516 -1.1667 TD [(LANCE are registered trademarks of PerkinElmer)54(, Inc. or its subsidiaries, in the United States and other countries. All other trademarks not owned by PerkinElmer)54(, Inc. or its subsidiaries t)-11(h)-11(a)-11(t)-11( )-11(a)-11(r)-11(e)]TJ 0 -1.16667 TD 0 Tc (depicted her)Tj 5.77563 0.00001 TD (ein ar)Tj 2.61035 0.00001 TD -0.0001 Tc (e)Tj 0.77772 0 Td 0 Tc [(the property of their respective owners. PerkinElmer r)-1(eserves the right to change this document at any time without notice and disclaims liability for editorial, pictorial)]TJ -9.1637 -1.16668 TD (or typographical er)Tj 8.72095 0.00001 TD (r)Tj 0.38892 0.00001 TD (ors.)Tj -9.10987 -2.33336 TD (007870_10)Tj ET Q /GS2 gs /GS1 gs q BT /F11 1 Tf 6 0 0 6 36 137.7119 Tm 0 0 0 1 k (PerkinElmer)Tj 5.83057 0.00001 TD -0.0001 Tc (,)Tj 0.5557 0 Td 0 Tc (Inc.)Tj ET Q /GS2 gs /GS1 gs q BT /F12 1 Tf 6 0 0 6 36 130.7119 Tm 0 0 0 1 k [(940 W)37(inter Street)]TJ 0 -1.16667 TD [(W)55(altham, MA 02451 USA)]TJ 0 -1.16666 TD (Phone: (800) 762-4000 or )Tj 0 -1.16667 TD ((+1) 203-925-4602)Tj ET Q /GS2 gs /GS1 gs q BT /F11 1 Tf 6 0 0 6 36 102.7119 Tm 0 0 0 1 k [(www)74(.perkinelmer)74(.com)]TJ ET 0.5 w 0 0 0 1 K 36 95.8519 m 558 95.8519 l S /GS2 gs 0 0 0 0 k 74.125 392.525 215.75 107.75 re f q 74.125 392.525 215.75 107.75 re W n q 198.15929 0 0 106.59 81.815 392.458 cm /Im2 Do Q Q /GS1 gs 0.25 w 74.125 392.525 215.75 107.75 re s /GS2 gs 307.125 392.525 215.75 107.75 re f q 168.42329 0 0 107.4978 323.619 392.5502 cm /Im3 Do Q /GS1 gs 307.125 392.525 215.75 107.75 re s /GS2 gs 74.125 227.447 215.75 107.75 re f q 74.125 227.447 215.75 107.75 re W n q 164.14549 0 0 107.7337 81.493 227.5322 cm /Im4 Do Q Q /GS1 gs 74.125 227.447 215.75 107.75 re s /GS2 gs 307.125 227.447 215.75 107.75 re f q 307.125 227.447 215.75 107.75 re W n q 163.9637 0 0 107.9155 324.028 227.3685 cm /Im5 Do Q Q /GS1 gs 307.125 227.447 215.75 107.75 re s Q /GS2 gs /GS1 gs q BT /F14 1 Tf 7.5 0 0 7.5 74 382.6442 Tm 0 0 0 1 k [(Aurora B enzyme was incuba)-4(ted a)-4(t concentra)-4(tions rang)-4(ing from 10 to 250 pM)]TJ 0 -1.2 TD (with 50 nM U)Tj ET Q /GS2 gs /GS1 gs q BT /F15 1 Tf 7.5 0 0 7.5 109.7751 373.6442 Tm 0 0 0 1 k (Light)Tj ET Q /GS2 gs /GS1 gs q BT /F14 1 Tf 7.5 0 0 7.5 122.8123 373.6442 Tm 0 0 0 1 k [(-Histone H3 (Thr3/Ser10) Peptide and 20 \265M )37(A)55(TP)128(.)-203(Kinase)]TJ -6.50831 -1.2 TD [(reactions were termina)-4(ted after 0 to 120 min b)-4(y the addition of EDT)55(A.)]TJ 31.06667 2.4 TD -0.01 Tc [(Serial dilutions of )37(A)54(TP rang)-4(ing from 10 nM to 1 mM were added to 100 pM )37(Aurora)]TJ 0 -1.2 TD -0.0097 Tc (B)Tj 0.72062 0 Td -0.01 Tc (and 50 nM U)Tj ET Q /GS2 gs /GS1 gs q BT /F15 1 Tf 7.5 0 0 7.5 346.3592 373.6442 Tm 0 0 0 1 k (Light)Tj ET Q /GS2 gs /GS1 gs q BT /F14 1 Tf 7.5 0 0 7.5 359.3964 373.6442 Tm 0 0 0 1 k -0.01 Tc [(-Histone H3 (Thr3/Ser10) Peptide.)-194(Kinase reactions were)]TJ -6.98618 -1.2 TD [(termina)-4(ted after 60 min b)-4(y the addition of EDT)54(A.)]TJ -31.06667 -19.63547 TD -0.019 Tc [(Serial dilutions of staurosporine rang)-4(ing from 0.03 nM to 0.3 \265M \(final concentra-)]TJ 0 -1.2 TD [(tions in 2% DMSO\) were incuba)-4(ted with 100 pM )37(Aurora B,)-185(50 nM U)]TJ ET Q /GS2 gs /GS1 gs q BT /F15 1 Tf 7.5 0 0 7.5 244.7236 208.3781 Tm 0 0 0 1 k (Light)Tj ET Q /GS2 gs /GS1 gs q BT /F14 1 Tf 7.5 0 0 7.5 257.7608 208.3781 Tm 0 0 0 1 k -0.019 Tc (-Histone H3)Tj -24.50144 -1.2 TD [((Thr3/Ser10) Peptide and 2 \265M )37(A)55(TP)129(.)-184(Kinase reactions were termina)-4(ted after 60 min)]TJ T* [(b)-4(y the addition of EDT)55(A.)]TJ 31.06667 3.66374 TD -0.029 Tc [(Aurora B enzyme a)-4(t 100 pM was incuba)-4(ted with 50 nM U)]TJ ET Q /GS2 gs /GS1 gs q BT /F15 1 Tf 7.5 0 0 7.5 448.5261 217.8562 Tm 0 0 0 1 k -0.015 Tc (Light)Tj ET Q /GS2 gs /GS1 gs q BT /F14 1 Tf 7.5 0 0 7.5 461.0233 217.8562 Tm 0 0 0 1 k -0.029 Tc (-Histone H3 (Thr3/Ser10))Tj -20.53644 -1.2 TD -0.015 Tc [(Peptide and 2 \265)-1(M )37(A)54(TP with or without 1 \265M staurosporine \(final concentra)-4(tions in)]TJ T* [(2)-1(%)-1( )-1(D)-1(M)-1(S)-1(O)-1(\))-1(.)-190(Kinase reactions were termina)-4(ted after 60 min b)-4(y the addition of EDT)55(A)-1(.)]TJ ET Q /GS2 gs /GS1 gs q BT /F6 1 Tf 8.5 0 0 8.5 74 506.3324 Tm 0 0 0 1 k [(Experiment 1: Enzymatic Time Course)-9292(Experiment 2: A)74(TP Titration)]TJ 0 -19.41177 TD [(Experiment 3: Enzyme Inhibition Curve)-9064(Experiment 4: Z\325-factor Determination)]TJ ET Q endstream endobj 14 0 obj << /Nums[0<>] >> endobj 15 0 obj << /BaseEncoding/MacRomanEncoding /Type/Encoding /Differences[32/space 38/ampersand 40/parenleft/parenright/asterisk 44/comma/hyphen/period/slash/zero/one/two/three 53/five/six 58/colon 65/A/B 68/D/E/F 72/H 75/K 77/M 80/P 82/R/S/T/U 97/a/b/c/d/e 103/g/h/i 108/l/m/n/o/p 114/r/s/t/u 121/y 165/bullet 170/trademark 181/mu] >> endobj 16 0 obj << /Subtype/Type1C /Length 19644 /Length1 19644 >> stream HelveticaNeue-Extended51pW   8LCopyright (c) 1990 Adobe Systems Incorporated. All Rights Reserved.Helvetica is a trademark of Linotype AG and/or its subsidiaries. The digitally encoded machine readable software for producing the Typefaces licensed to you is copyrighted (c) 1990 Adobe Systems. All Rights Reserved. This software is the property of Adobe Systems Incorporated and its licensors, and may not be reproduced, used, displayed, modified, disclosed or transferred without the express written approval of Adobe. The digitally encoded machine readable outline data for producing the Typefaces licensed to you is copyrighted (c) 1981 Linotype AG and/or its subsidiaries. All Rights Reserved. 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All Rights Reserved.Helvetica is a trademark of Linotype AG and/or its subsidiaries. The digitally encoded machine readable software for producing the Typefaces licensed to you is copyrighted (c) 1990 Adobe Systems. All Rights Reserved. This software is the property of Adobe Systems Incorporated and its licensors, and may not be reproduced, used, displayed, modified, disclosed or transferred without the express written approval of Adobe. The digitally encoded machine readable outline data for producing the Typefaces licensed to you is copyrighted (c) 1981 Linotype AG and/or its subsidiaries. All Rights Reserved. This data is the property of Linotype AG and/or its subsidiaries and may not be reproduced, used, displayed, modified, disclosed or transferred without the express written approval of Linotype AG and/or its subsidiaries. 12 Helvetica* 53 Extended 47472 Helvetica 53 ExtendedHelvetica Neue4[Mw ?c:}7"7i,  v  ) I  M c & a 0 #m5U~GDP, hwbo(]\t-PfE.c= $ ? 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All Rights Reserved.Helvetica is a trademark of Linotype-Hell AG and/or its subsidiaries. The digitally encoded machine readable software for producing the Typefaces licensed to you is copyrighted (c) 1988, 1990, 1993 Adobe Systems. All Rights Reserved. This software is the property of Adobe Systems Incorporated and its licensors, and may not be reproduced, used, displayed, modified, disclosed or transferred without the express written approval of Adobe. The digitally encoded machine readable outline data for producing the Typefaces licensed to you is copyrighted (c) 1981 Linotype-Hell AG and/or its subsidiaries. All Rights Reserved. This data is the property of Linotype-Hell AG and/or its subsidiaries and may not be reproduced, used, displayed, modified, disclosed or transferred without the express written approval of Linotype-Hell AG and/or its subsidiaries. 12 pt. 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All Rights Reserved.Helvetica is a trademark of Linotype-Hell AG and/or its subsidiaries. The digitally encoded machine readable software for producing the Typefaces licensed to you is copyrighted (c) 1988, 1990, 1993 Adobe Systems. All Rights Reserved. This software is the property of Adobe Systems Incorporated and its licensors, and may not be reproduced, used, displayed, modified, disclosed or transferred without the express written approval of Adobe. The digitally encoded machine readable outline data for producing the Typefaces licensed to you is copyrighted (c) 1981 Linotype-Hell AG and/or its subsidiaries. All Rights Reserved. This data is the property of Linotype-Hell AG and/or its subsidiaries and may not be reproduced, used, displayed, modified, disclosed or transferred without the express written approval of Linotype-Hell AG and/or its subsidiaries. 12 pt. 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All Rights Reserved. The digitally encoded machine readable software for producing the Typefaces licensed to you is copyrighted (c) 1988 Adobe Systems. All rights reserved. This software is the property of Adobe Systems Incorporated and its licensors, and may not be reproduced, used, displayed, modified, disclosed, or transferred without the express written approval of Adobe. The digitally encoded machine readable outline data for producing the Typefaces provided as part of your laser printer is copyrighted (c) 1981 Linotype All Rights Reserved. This data is the property of Linotype and may not be reproduced, used, displayed, modified, disclosed or transferred without the express written approval of Linotype. Universal Greek w. 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All Rights Reserved.Helvetica is a trademark of Linotype-Hell AG and/or its subsidiaries. The digitally encoded machine readable software for producing the Typefaces licensed to you is copyrighted (c) 1988, 1990, 1993 Adobe Systems. All Rights Reserved. This software is the property of Adobe Systems Incorporated and its licensors, and may not be reproduced, used, displayed, modified, disclosed or transferred without the express written approval of Adobe. The digitally encoded machine readable outline data for producing the Typefaces licensed to you is copyrighted (c) 1981 Linotype-Hell AG and/or its subsidiaries. All Rights Reserved. This data is the property of Linotype-Hell AG and/or its subsidiaries and may not be reproduced, used, displayed, modified, disclosed or transferred without the express written approval of Linotype-Hell AG and/or its subsidiaries. 12 pt. 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All Rights Reserved.Helvetica is a trademark of Linotype-Hell AG and/or its subsidiaries. The digitally encoded machine readable software for producing the Typefaces licensed to you is copyrighted (c) 1993 Adobe Systems. All Rights Reserved. This software is the property of Adobe Systems Incorporated and its licensors, and may not be reproduced, used, displayed, modified, disclosed or transferred without the express written approval of Adobe. The digitally encoded machine readable outline data for producing the Typefaces licensed to you is copyrighted (c) 1981 Linotype-Hell AG and/or its subsidiaries. All Rights Reserved. This data is the property of Linotype-Hell AG and/or its subsidiaries and may not be reproduced, used, displayed, modified, disclosed or transferred without the express written approval of Linotype-Hell AG and/or its subsidiaries. 12 pt. 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All Rights Reserved.Helvetica is a trademark of Linotype AG and/or its subsidiaries. The digitally encoded machine readable software for producing the Typefaces licensed to you is copyrighted (c) 1990 Adobe Systems. All Rights Reserved. This software is the property of Adobe Systems Incorporated and its licensors, and may not be reproduced, used, displayed, modified, disclosed or transferred without the express written approval of Adobe. The digitally encoded machine readable outline data for producing the Typefaces licensed to you is copyrighted (c) 1981 Linotype AG and/or its subsidiaries. All Rights Reserved. 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All Rights Reserved.Helvetica is a trademark of Linotype AG and/or its subsidiaries. The digitally encoded machine readable software for producing the Typefaces licensed to you is copyrighted (c) 1990 Adobe Systems. All Rights Reserved. This software is the property of Adobe Systems Incorporated and its licensors, and may not be reproduced, used, displayed, modified, disclosed or transferred without the express written approval of Adobe. The digitally encoded machine readable outline data for producing the Typefaces licensed to you is copyrighted (c) 1981 Linotype AG and/or its subsidiaries. All Rights Reserved. This data is the property of Linotype AG and/or its subsidiaries and may not be reproduced, used, displayed, modified, disclosed or transferred without the express written approval of Linotype AG and/or its subsidiaries. 12 Helvetica* 73 Bold Extended 30472 Helvetica 73 Bold ExtendedHelvetica Neue0_{T y^'Mq M  7  S m 2 x Z4\HkMR7x+p5y+kAX#D_,`{=d#;j 2 X !?!u":""""#)#B#s###$?$n$$$%4%%&q&')''('()=))**N**+x+,,{,,- -|./.}//+//0\01V12;23%34>445C556 6P667l78o89s::x:;K;;>?@PAAB(BC=CCD2DuDE'EFFFGqH HkHIFIJJJ>vwwVp {wV^V>VQvvwd:vDUDrDD77DrDDrD(y(:wvvdqbTPbX}VZiiBA.kћVzKTb2Dw ;%3rR\4$A8;&P22t}}wlal @ % @  @$$ O$$O@  ՗O[[OAAǻG @$$ O$$O@  ՗O[[OAAǻgVZr)w#>LPJ>,2.g`W}OK<࿾lM>|gcSkl."٢ռbNlen:F/EAܦ{wd\Yqe{x^vvwVHwoJyEVbv^wDR0Y0660 @;<<; bv^wTDBR ;<<@; 066Y00Nvv w4M/iZi)`YvSSSSSSSS>VHwoJyEV=vnn>VV>VtvwBw:yjPPz^^P}~&o}~~}-vOJJJ!cR.f:R\\ܤS3 R5M[\٫߼cQ?y4^:yOrvgV\FbuHMRg&@-VIKfT5љ/y:@aEwV̙ƩoNhqbL':"s>ps>pHqAK:y VLȘv';Ud8Py\Kba(S>FHF(T-mZY:ysPV5{<8CTa2^"8NH&?;v[X ȂK0BMXFKc5bvT=*LDh|t2:++-T:y]rva\AVV=\+mEDHm')HΩQE?S6ԥՍ4X!!Xm4A^q6uSN5?EVQ֊M%axQ^hf :ysVPM5X>V`V>VV>V>X>VHwoJyEV`XV>VYv]eeYvYvee>DPVV_zF%a/5HMPʱiT~RzV>V*wkŽͶh^MYBE^n{:maX6JgyQkNBMnE6knF3p1eTAm/9 92>- 1(MH^2L.}ptre^~^ep'>.V\BbϮmS^tdOVl _8Π*#V۟k^Vos^wvbPno@66w?dgx0^-Ld$$LX$NV&\Z(9+Q>lVbt"kk!"Q8(V3q8UU(m/Ӡv0VV440Pw,v\bA t9c!DMDq/lXhOZ,0q6|8"vwV&VV&V^V&VԠv^wVV^VwwVpV;7}O&JcV^_.`:CHVpv^wV+V^Vh?Ӌ"wV "GVtv"PP\h^PЍv6vP^vlP2P2l u^Pg^Pwvbpb)xx))OxOx)bDDMDDMKv[V\vă.+EOdVV1,Z _twvbpbutqDMDDU}Qf]72)x'۟)OxOx))xΕ^vHVVPbyDHYs`V"VǶr'@njhi߮~6ܨj Z9wnabn^~n'tJ3& fxEp|TMMp07)nsvuB(Yk.ӠvVVhpwwVV;XX^V.E FF .V&>wub^icciVws\**\v^V&V&V&vvwzzBB}1r1r}v^wVVexMMxeNkЛkllZKLlZbR$>R4$4tvwBwbR$U>^4$4YvJw|H OO*vvwVV>1Ο̝zK;w7CvP>m1(`2I^ɐ񔮎դv``yUO~ oZ ~xxxDU$,x9vwDwDJzV%%>V23>|>>΍C|BPB=(Bk[iDwJaEj3h"5^^5^CRJHPa=LtDwDwJDmV%%>V32>|>jDiB(=BO,;֝w JJ4]rYsD Wپ^ |h"5^^"5h591ntv6  D D6! !`_s8_p$p i JDms0s=>0T];=t,&f֢ý`@t4%iP6G|t M>v2DwDDDдڲgAD20$7\^qDvwDDD0DD[wDǝIvSzyED0DDӠvwfwDD.Cs}`}\DvjwDDjDtv2DDDD!")AfKZpS%$7\^k>DdzּwCDdzԾwCv2DDD20$7\^k>DдڲgAwJJ^"5hh"^^"hh"5^JP""LPLFvGDJzV%%>V23>>dD[k=BPBAP|CH>FvGJDmV%%>V32>ZHPAB-PB=ԫDs>v%v .wDD{ ̬9wsw'Yf9K>wvJV:P_-F3QG?~Џ{TVQ&'h%%h|4umd\x;0kb  D  *M;͑ opl]~" ":Dw8wDDx>D(UV,:dD2hߺvwH~\\& & \*>w\gg\V>VӠvvwl8quuEEywo[w{<p(-Sydwfwy`rqrХbR> .YZ5SZ^i[5dXL/` c_*kHƓ@vwwbR#>#eh^c 轼SWbLR5 he*Ha΂Pc`OYv1Tbrc`djnjjgZQehXp!zzzzű1vww>VFVmw0mV>V:w}nJ\6[+HJO[cHldžpMJ\l;#M6R2QQ2R:w.(J\ Dp\zxxE^eTivcПWinIuOv>JSggj~8F~׷f=\L4FeKgnkRwvrw%]%wr,:n/wVVx\\AiqD@ud/Adb\/\:[ \ Q L̀Rp|Txxt2% Әċbm\݂~{Xozvxy[B:v #,M66PM99PDƵm{PPƩ{nDQQaWTUW{n`QDDQn`{WUTVbvvwQvvwVVV>1Ο̝zK;V>1Ο̝zK;dvvNwVVcV" V"2V" V"vvNwVcV" V"vvNwVV"2V" 3 3Ӡv6 % DUDzDDDDjD6! !ܬ`_s8_p$p Ӡv6 % DUDzDjDjD6! !ܬ`_s8_p$p *vtt:FvfwJ[JfJf:FvawvawD[DJaVaDJav@bbS\»[TT[\SmvzzG)&a4F)*v[vw(;;((;;(6vwVHwoJyEVQ6vwVVHwoJyEV>HwoJyEVQvvwVVHwoJyEV>HwoJyEVdvvNwVVV"2V" 3 3V"2V" 3 3>VVVpV>V>V>V>V>Vwtϙt<SF##FS<ԘØdBB~dSS~ SF##FSԘØdBB~dSS~SF##FSԘØdBB~dSS~HZr)RD>VVPzF%Ca/5MP1Le<FM~nRPMV>Vv"H42"kv"4$"kv"D:P$"|v"mYו9oypO!W>`Q;tvvvvv>n>}s)WM``Mv DD Dv &DD&D D D DvYERREERREnggnnggnivv!8yvsxnqpopzW\[}||Lv" 84$"k "4$"kivs|jtC=uYbLTk඿v"}D>:<P$"|vt|t||(Dt\g::*8(&{wcwbpb짠X^mx)z@`'5G+Ox)<&=(tDtjVb\_MDBUfw8(V>v8(SRD;d;jc:dš>pS3#0,K+5w$vNh W //W Ĵ̴hRQbgJJbw/vJ(v0E^&`Hӑ ȚȂLm}EG,UN2] Y_!DZhj{N)Jo+ \,=kefM0BJ$UxZb5vwDDDvjwDDǵOaDO]ǹwJJH}u^uni"LP[dp^dzh"^s_e8GP8*h"5^5J^w D"l!ٝܿ_8<)t+ \#@^`dJ;6B6$GuDZhj{N>Gv"/_? _?1 n8DP!J|DgоpRS`sCOjE.AuEglqx==R8Ȳ.A` RPvv,,4qLf*/YvAAFvG8wDD=D(UV,:dDsDdzӵC>v1E0>88>0O)>(V&\bt"kk!"QGVZ(9+Q>l>::ЌvevwR(?(wr,|^ΜęDzӋR;"f(ƒsi+~h4qLf*/Y*"SSSSSKZV\l\vă/+EOdVVl1,YO\VЌv;5 vwR8;'_'79)9&r,`@4qLf*/YSVV_VS0*U``UU``U<U``UU``U@w`w`v6((9II99II9jbbjjbbjFvGDwDJzV%%>V23>>dD[k=BPB6ImR`DЌv;5m"?(( `'wr,~glfuU_U"e\ѻgSWK'r!~zruz{b6V`9)9''77 v(?(ΜęDzӋR;"f(ƒsi+~*w *88$<ǒX5A^_ocGel?33??33?d==dd==dd==dd==dYvSSwUwwJDmV-1LPLadWLT).~W_ogElQJ.61DT"5h"@H HHYvvwv5/0/00/0/5/0/0550/ v"?((Wb~glfuU_U"e\ѻgSK'r!~zruz{b6*wbfq\L`Բϻqe}=1?,*d==dd==dd==dd==d?33??33?L."}24$"k#htre^~^eh'L."}G2D:P$"|htre^~^eh'L. }*DD2&D D D Dlhtre^~^eh'L."}242"kphtre^~^eh'L.}(YERREERREnggnnggndtre^~^ed'L."}92mYו9oypO!W>`Q;t?htre^~^eh'ivvvbq3x0^-Ld$$LX$eno@6y}`Iyvsxnqpo^zW\[}||s`Q;tm2l u^Pg^Pwv"bĴb2(4$"kZԧ)xx))OxOx)bDDMDDMwv"buub2(D:P$"|ԧ)xx))OxOx)bDDMDDMwv bDDb2(&D D$ D Dҧ)xx))OxOx)bDDMDDMwv"bb2(42"kԧ)xx))OxOx)bDDMDDMwv"bb2(mYו9oypO!W>`Q;tvԧ)xx))OxOx)bDDMDDM9w"nab//n2$}D>:<P$"|^~n'tJ3& fxEp|TMMp07)nsvuB(Yk.pww"V{V2(4$"k5;XX^V.E FF .Vpww"V<:<P$"|țkllZKLlZw7Cv"PV>4$"k}m1(`2I^ɐ񔮎դv``yUO~ oZ zxxxDU$,x9vw7Cv"P">D:P$"|}m1(`2I^ɐ񔮎դv``yUO~ oZ zxxxDU$,x9vw7Cv P?DD4>&D D D D>e@m1(`2I^ɐ񔮎դv``yUO~ oZ z@xxxDU$,x9vw7Cv"Paİ>42"kB}m1(`2I^ɐ񔮎դv``yUO~ oZ zxxxDU$,x9vw7CvPɔ>YERREERREnggnnggnY m1(`2I^ɐ񔮎դv``yUO~ oZ y xxxDU$,x9vw7Cv"P0%>mYו9oypO!W>`Q;tm1(`2I^ɐ񔮎դv``yUO~ oZ zxxxDU$,x9vivv J9iHPa=LtDJEj3h"5^L3B~aIyvsxnqpo^zW\[}||>Nw "JmJ4$"k}4]rYsD Wپ^ |h"5^^"5h591nw "J..JD:P$"|}4]rYsD Wپ^ |h"5^^"5h591nw  JKDDKJ&D D D DFe4]rYsD Wپ^ |h"5^^"5h591nw "JmJ42"kJ}4]rYsD Wپ^ |h"5^^"5h591nvw"D04$"k}DDvw"D0D:P$"|k}DDvw 8DjDjD0&D D$ D D_eDDvw"ZWD042"k}DDv2"DDmYו9oypO!W>`Q;tD20$7\^k>DдڲgAw"JrJ(4$"k}Ԯ^"5hh"^^"hh"5^JP""LPLw"J33J(D:P$"|}Ԯ^"5hh"^^"hh"5^JP""LPLw JPDDPJ(&D D$ D DPeҮ^"5hh"^^"hh"5^JP""LPLw"JrJ(42"kT}Ԯ^"5hh"^^"hh"5^JP""LPLw"JAAJ(mYו9oypO!W>`Q;t#Ԯ^"5hh"^^"hh"5^JP""LPLwv"JVr}D>:<P$"|h:P_-F3QG?~Џ{TVQ&'h%%h|4umd\x;0kw8w"DLD4$"k}j>D(UV,:dD2hߺw8w"DDD:P$"|}j>D(UV,:dD2hߺw8w D+DD*D&D D D D>ei>D(UV,:dD2hߺw8w"DMĦD42"kB}j>D(UV,:dD2hߺ[w"{:<P$"|Lȥw^Zݗ D  endstream endobj 53 0 obj << /FontFile3 52 0 R /XHeight 734 /Ascent 714 /Type/FontDescriptor /Flags 262240 /Descent -199 /CapHeight 694 /FontName/HelveticaNeue-BoldExtObl /StemH 0 /FontBBox[-190 -213 1372 984] /ItalicAngle -12 /StemV 176 >> endobj 54 0 obj << /BaseFont/HelveticaNeue-BoldExtObl /Type/Font /Subtype/Type1 /FirstChar 85 /Encoding 51 0 R /Widths[870 0 0 0 0 0 0 0 0 0 0 0 741 0 0 0 0 0 0 0 0 0 0 296 0 0 0 0 0 519 0 444] /LastChar 116 /FontDescriptor 53 0 R /Name/F9 >> endobj 55 0 obj << /BaseEncoding/MacRomanEncoding /Type/Encoding /Differences[168/registered] >> endobj 56 0 obj << /Subtype/Type1C /Length 19394 /Length1 19394 >> stream HelveticaNeue-Roman4:jL   eK001.102Copyright (c) 1988, 1990, 1993 Adobe Systems Incorporated. All Rights Reserved.Helvetica is a trademark of Linotype-Hell AG and/or its subsidiaries. The digitally encoded machine readable software for producing the Typefaces licensed to you is copyrighted (c) 1988, 1990, 1993 Adobe Systems. All Rights Reserved. This software is the property of Adobe Systems Incorporated and its licensors, and may not be reproduced, used, displayed, modified, disclosed or transferred without the express written approval of Adobe. The digitally encoded machine readable outline data for producing the Typefaces licensed to you is copyrighted (c) 1981 Linotype-Hell AG and/or its subsidiaries. All Rights Reserved. This data is the property of Linotype-Hell AG and/or its subsidiaries and may not be reproduced, used, displayed, modified, disclosed or transferred without the express written approval of Linotype-Hell AG and/or its subsidiaries. 12 pt Helvetica* 55 Roman 05472 Helvetica 55 RomanHelvetica Neue9aY|@d1&"9n< !  8 X $ Y o , j E  5 *D`?>H$}XHv$g1Gy!<`<InQ` # o !%!j!!!!"=""#h#$!$$% %x%&g&&&'D'((;(()")=)w)*k*+K+a+,,w--]-..s./o0 0O00121g11223334t556 6p67(7v7889\9:;Z<'<=-=>0>>??V?@@u@APABJBC,CCDKDEEmvw$hE^,p$tv\\G G-vb*|bnbb0*2aFnaaFnaGv* Gtnv**-zK5H[׾˒vq?5Ug@/7~9XOǀcJqLTI19  a!i;Qn@@@Pu|6 1 gd+ ֍ǘ֕5PM7?@\1 gd+ \֍ǘ֕5PM7?@wav(v8/(WhWjJFHıαv5ʖ:ee~h1в72$QF=BeR0[?SQUܭζKlehbOUebqv\]~X^YجEv5wZ,-f'<6)*J%T=0C#*Ev5wZ=0CN#+*J-'<6f),*vE]^V!y[eJ0l+Iw cYvoGonGnoonnk|Y^|YءvяvwyyzB-0`rr`01}`rr}`1H%%H"!H%%H-vYJ x3q*GL-^X>)N_ A'M6O}<cʋ)*6 $-zEOn\25DX8*X6&6$"a5l."C-ތcA>LdC~-v:7YGa9::+-/jMIԇH-FT:6PԆ6@9 6$[V{hl`-FEB37XB/.Ui'B ^PMW)TfG:>OoJc4%(ηaK-v"M_;)2o{r#"-msJM\Q>Nzvk7w+kk^"5 wJAmq.=WY9,;"[3xͦf\`8L;R}(@_dRz7,u)p =cd8rHF, C3?C7) >X&"zp;4C$>CyJ2dw%w"?vww izavnd ;x3$'35)-*AZ;p0vHdNBiӠvw  ^, ,v^w^,zwyM^,,-wm,qvt wlss^vuӠv^wэ ^1׉ &zVHwwHVVHwwHV$*BB*$$B*BBB*$vn">";N]66Z\ Nz_v!xX-ѯVHwwHVVHwĚH3dLm~kfBB*$$*BB*$5q3ST,v=AWE#?t2|PEE|>ncمфz8tᣱ8zGJX1&K%jrrz)$,p5' 1B=4), Xۨ_%?v;zw^,\IF C\,\R6LFHdv^w^(b`$^v tw&^,%`2$4 *K^97dv^wZT!NFv^w^ej:d[O;.PZoO5O яvwyoBZZO5OG YvvEwFInEK*v\WP>jG<EH\]EW[ʻÕĕˌ[p &.X(^׏AK;-y3z4r $aʤºSsRLMwg&d( ]-*H$ЍNw2&&<3DIrRo6- 8;/.24=Z[9`ѸeJRLMw^6e?V2=&&3ͤħDE$ -%*_)Y>&98H|ZiEXS?K!%/29$ڑJ:vNN'{t{.Y_7>4@?fLEi-0*a$T;AlQJGO+! 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All Rights Reserved.Melior is a trademark of Linotype AG and/or its subsidiaries.Melior BoldMeliorZ2b1KoohA  N t 3  r g r Z=0 #:~qEZm,ES I !+!e!"Q"#$+$$$%X%%&m''3'(X))z))*D*k*+D++,T--'-y--..r.//0e0001-1D1q1122O222334s45f6,6|7=7v7878999:z;.; >'>g>?@@AAABDBCDnECFFGHHHIJ{K,KL)LM6NNOOPBPQR1RST"TUVEVWXY2YZ[d[\v]]^^i^_H```aabccdceefzgMgс9vw"!!p~< O\)w}ЋʋaJ0n_I-0&74 7(DUmDbŒŒ %#ua-P,)%v勏3GO49щ~zJyyya",P#S^zcc+􍑉-޵U)5(]ja8tG?i9=0׋-G]p_qӋ`T{/KS 6/Ҏ-wڴgʼnS4P7S5*| %VBC-u)m&)XB̋݋;JQ5<<5͒HVYGDDϽȀ20-NNb4ѕgBBgF8HR~BȀ4b>9-8ϵ߳( 6* M]:9Kƃ1=D2?K++FzƋoYh|v#sxXAqZ949!`r]_qoUVor]_qoUVo648*%(ڳvSTyeZdUTgi\oPEw\Xyh^\f_vw4"KzAz_v 55_vw7zz7"Kb9!hĐR_/r`)X}B̿a1&2^}{!r]_qoUVoȢt$H`ʾ9گbm`|Oyci|hO_(l])8Nħaa͹)Sc-5`c:#]I QtLj\szb\jr"*yY+~r|jNtbċČĊċ %:qOyzyyyy $U4M*R1n;pLxyy~Vb %oN/t&F)1i!$Uv]7 GpK[~ÊË %/]/ڴ;MMMMLM %bݐuKVOu7 4`@kRm80DQ"j@3H1 wyΖ̧҉4}kRRRR< %&& Nw%bċČĊċ %*llNw%bċČĊċ %*V˂\RRRR\ %b{wNMM˂\RRRR\ %b{wN &͍{RRRRRR %b{|IVI|bxċĊ͉v&1to>Ci͍{RRRRRR %b{|IӉ& Mw%bċČĊċ %*j/!# %B^ullledd %b{|pDV^33]˂\RRRR\ %b{wNd&˂\RRRR` 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All Rights Reserved.Melior is a trademark of Linotype AG and/or its subsidiaries.Melior ItalicMeliorQH.s@[yE&x6 > b  K F c CNO G1@ )Px/ r64> b !:!"C"#3#$$q% %&`&''&''(()>)Z*!*+Z++,O,,,-.~.///0D0k001;11223"3L3m3334 4Z4455I5m56b67O7899::q:;?Q?@@A1AOAB C)CD]DsDE'EFTGGH^I IJK2LLMNO!OPKPQRYRSTATUVWW WXY\Z4Z[L[\]*]^_7_`naab9bc=cdee~ffwg ghWiijzk:llсvwb9hUK 'PW|^`['quxmbvbhow*vp{> _pBzsuu~kgQgBkuu~kgQ-vu'*fQmffQlf OvPjuuluuWw-A䵓eruz?-=R3Xd(˼ڎDha KwjOĠWeG~̃Év+ŋ/72B~e%e6"P_Qw'[[›^]Bd0Wzӯdx^y<9[P6E ]\›_\,Dc1V{ӯn7a P6D ӁUaGҽٝzuLyjH6yzocx߱qW|/"Q ?}t%nKFcDE&o.њ@Og1?c(׸㗘}^_vP:%P٠undrdgh|}T]dXwѠv}w}*Nfm#w { iYi-*zA} .w.߉ƹc uj^OAb It_PCvvw93~-E0C4gKe%Uʴ_vqoKooooooKբzidrdgg~|U^dXwѠvXX}Exmbvbhowvw;P-٫ ʧcP&[2?tӮ/פKR!X^-r$])ƥ b-PP\q4d(}~ʎrUAc"6C]-*`Hz>z@fAk %Xb0\:![F-$z ~Ef΢eM_ sswd't6;D2VT{ed[-\j̡_Q'` ItD - )N2QMu^e2'4w[~{A@CDzUX:5Xc`-wRM}R}O‹9U V K-ƭDTӲlA'V&HkE%rI@ d$dH*ۛ>9P (XcjvU?c03YiԹ-[ 6##80Vǡzf.dbx|w|}|/i2ڼ#U9 Ml#Ϡ^L,^p\.xmbvbhowPxmbvbhowlbڡvmbuafh|U^dXwP-GFGccc %ikP HY$l W36*/diñi4t %ϗњT"p}\'GωhDќ_-sdg(3qpldڕbbb %ijw|^9|4n/Ṟi43qpp`ڕbbb %؅ijw|^9|4n/i %ecVύgEќ_-sdg(Ӂllz^]^]^] %jTHZ"E,ͿCoD1?AO@$ cCb?p65V(_ᰛĖͱ1ኩ^^^^^^ %ijw|^9y5m/i %`cWcWy5m/i %`cዩ^^^^^^ %ijw|^i1щ**|4n/i %`c䏦^^^^^^ %ijw|^Ѡv&^m^_њҸԓ3㊧荑^^^^^^ %i}qw|^w1b6.dϡ %23(o@]ϒssssrs %oouPV7@8>0G?⌨^^^^^^ %ijw|^9y5m/i %`c-ipȌNjȌ %ϗњTp}\'G⋨^^^^^^ %icw|^9|4n/bS cpoopj %if&gv8t/i %(Xܑq׍.Oy5m/i %`cnonnnn %*v8t/i %(RYQf՚ʙэfeffef %i`/%X"R.\opoopo %ifZ?7 l1;=4Z M?F ޻l@ 4i`>(S:SQ d!ʹy<+7A(uwxfIyE ;#XYXRQR %ijw|^9|4n/i %`c_캬LFJqd> :@4[!mw|y_`m{wɜzbPkY~BRwI_f^WIhفLkegfipRxᏗJo"PSY 4Z[ZTST %ijw|^9}7k2i %`cSdsp:CXAHuikՄ*!/N( SbS{݁͋'<!TS`<^ _,z yxi~KB_B |4n/i %`c ⋧荑^^^^^^ %i_x|^KeJKOD3܊㉓dddddd %iߋ{4z.v,r0c"iD? Ӌխ P HKw `_``_` %iҍ0NOOPfN΋eeeede %i䋊rI8k`Xϭѕkjkkjk %ijp{jrN*G(C&(n<2]6d)Zw|bcbbcb %iĈzR****+*ӉF,Nku]^]]]] %iR5.,qqqiOi %s}oAEA_}_ni %Ht{Yba/*cbcbcb %i͉y!!Ӊ?@G~\\\\\\ %i؊n`Zl<~Zq4k&i %8$|8AՑefeeee %ixx}x|Yd:bI͋d u`[vYhyrzrrrUWJNP_vwU}  q4#eGPOe_v JIn*Io****YvS-9J-vM]MϨTN(Y_TYɱ좪 p"gzI5:I!UYvff<k]xZxahOu*6wZMZ8V ]vWSR `ɶmPs`[@5z֍J(܈mhidp)7d ̴aKYU$RalRVE;L+/Q޿ɽ|y@ %Ex  Ԙգ;kȉ{H*o<=ᢱɠ_TusteC0=CmK]aPo,BZ i|tqPgaDFi͋ѠvEH33KEw s y tiRuunnFÅz~ ߢ6]9\d]H'yk*cuˬF;@Ō?6\DN4­k\[Z @/fgv@l`~@_YpJeI"rϋ(ENF0w⃘*psX?i -Zgݩd#}7k`wvp![uRzk %s`bӧNJmTA $nbQTAFmdT㉫' lek{|vzR~JzLk %Yq%0}staueeo|vH eeny|wzBpy/#tr=(C~stauefp{-)|gpopopo %||wyNVE^F\123<kX{wp!|J~Jk %s`%@:0 %TlnD; ʋ㉫?9}kȌzM"uzybtHk %fy'be2l}NQ{MGk %lkK㛸o5K}eEzHIk %mlT朶|BN~J %giOIICtZ^ĂUXIDkZed#ce5mȉ~MT[uRzk %lhbٮqc< %\tCJAFmP_-2oB):[ G%M2)eثeASQ ?ha%df(pe0k]iCkE\AzL~Lk %Zo$_{EI-XR)>TqP\U%ZcH`V6ȍaO-f2Ifc½pNem&c#kX[A0?1$Ux=zryWIWgM^_YсeD1tj-/eIӈ|j~dyȬŶyyphllZd)ggpppppp %keXj}jJvҢ̷{< %c]}prqqrq %k^baw+bR%`^ulmllll %kÎ{}ktVnWjV'3\ʌffffef %kmm6giiiihi %k]]  `ܠopoooo %kze_&O%S$zPGG?|ᡃ-)%_VocQk %tg³^_\ootk %jq{&EѼlmllml %k{l-AssJghgghg %k}^2QTwcs@,Zjmi~omu½llllkl %k{`x~v0XӂĔЌffffef %kd*tj)XVwzO72!KKKKKK $j"/$lΌ͌͊ $Ѡv}wk?=JwjJxylFp6voN~Ч<։FӝөGѤϛ'Pv w_vwIѠv}wNk X'{dEmGCcy@y{^~@o<Gp`J~6КНP_vRʒUDcNTlc|}m̻hxec[]qdccahZvw8ac~^Ɖ'tk(zgqakptwm-6OJ(|o{\qwuuigSttv8V ]vWSROctP/ڣɶmPs`[@it{-Qq?~#KTmG\ԛ-L⋵!jd}a]N=;pmsIE٢d|SRx>UOR8.kewwFwgM7F[7F-A۱' eppq3e4v1wH}Cj %_\ 46}()5Րeggfgf %jyy}y|RoC?^^^^^^ %jՊnc-fw{al}Adzk{|wyc|V{ذS  <}[}y]H5gye-.f̪ըZ>nnqY3&;M6NdnkZGMWJocoXuQJs̋ ̋J±ò>Q_HYy^}wGJ'LmqqYtFPPSmk-vhŹdvNjĠQQűwchQR`TTQPxd`NhgOcazRRRV_Y3# 53! 3Ѡvtu4(Rt-jdyrsW?*vZ":9Q;xA.9nsnl~cmTTWbne`b|F|AiN¢t|"A-wDFwΐ}G}Cgpll.ƚȩ\zeP{QR4nnolqhV<jklhpo݊\z7mdv  jqpkjqpk*t\%73kDc"lE(_>eKJ'J,ؚӛ*vVvw*;=(*;;+:؝undregh|}U\eYv*:9ڞvmctegf{V^dYvLt؝undregh|}U\eYv*v\7:9C\ڝtodrdhg|}T\eYuctڞvmdsdh`}S]fXu-v&wILSkU=Z[GSkU=Z[GrrpMbvbhowxmbvbhowxmbvbhowxmwvv/|-Ϻ/H]SC*M(2EU^ɪմl_Uq$CxSI-E30AP_ȯѮgdXo'C<L+L/2FKUAvfdTkI]#bh,2.@612rݽm}SkTOZk{~sxPxmbvbhowvCU!{w~}|~q|{%vTw7v{|w~|~~"%v QQ2>%vvohlKoWSɩjtxpyytvTvwF,JߛlOt^fILbˈvO nsrnnssnv nrrnnssn_nsrnnssnv  ø^ST]^ST]Opjkookko*kmT|ڠVXfI*ĆemozovnyvA2)柗{|w~|~~"%u)柗{|w~|~~"%Y y}|{vt|iol`dWbqv> Q#0b>5>vY|Y|Gisilv@*njNjnj %ϗњT"p}\'!ύgEќ_-sdgA -uunYٕTUT %i͇e\xohiOEi %zSqq|4n/Рvʱww2qiPq._˫Ktrg ]DQi˹d\{Y-ipȌNjȌ %ϗњTp}\'Gޓ8&⋨^^^^^^ %icw|^]c+Mdm$y5m/wĮT jIʋmVlwto1m_;&T:O IIhT4H l1<" > @FqXzӋ ޼~kuorv͌̋͌͊̋ %ϗњT"p}\'!ϊhEќ_-sdgM-qpgiڕIIIIII %+l28+Z!f.Ѡvwxehl{X{{{θRzCBx $E_v LMde)p  %c]}prqqrq %k^ba+wbR%`^pppppp %keb` Ң̷Pvws ߀PдŞ~P+ƞcPw^_aw2aygixlwlx,*Ӊ̱i HY$l W36*/ƊNj %ÓٿM'>-GFGccc %؅ikPbO.eYzZiQoL5dwFehl{X{{{θRzCBx $E`F7F[7F϶]XNNFgMoA-BVSxh~|`_moKo33oo3KKdw!ͳ y<+7A(uwx)b|4n/i %`cIyE ;#\]\珦荑^^^tQR %ijw|^Lw?iwGFehl{X{{{θRzCBx $Ea^s[x %jpPjʬ D|za_M#7F[7F_Pq(onsrnnssnnsrnnssn_vwI[IvppGyG98GG98HcNYZONZNJȽYOdf-kpZo$_{EI-R)>YqP^?k]PRS{J~Pk %%ZcH`V6ȍaOLw4 |wÖݑiHa^s[x %jpPjʬ D|za_M#7F[7FufH[aSYnt}lhWyŒ㌳sb$UYRCtOyq_yPT\jѠv5*϶]XNNFgMoA-BVSxh~|`쁷MwAͷW)A<Y44ZZ43YZ43ZZ44ZA! BB!AA BB AKъ7C|`yzr_YÒ7F.zlj~i{*g)(±pR@O}L_vqqK-2wIثeASQ ?ha%DZQMljmB):[ >.jaJeJYPMjxyoj77k_vNwODD^DDDDDDDD]DDDD^^Ѡv7|Öݑi܀vNuf[aSYnt}lhWyŒsb@UYRCtOyq@_yPT\j쁷ͷ 6[53[X36YW45XZ54Y_A" A@ !?A"@B"C6D`Y]:84 Ѯʤvu[^oU+YаcIyw_vk{|w~|~~"%z~K;?i %gz3D8n`m %h]ĘQ`2_kQQ2>%9~K;?i %gz3D8n`m %h]ĘQ`_k nrrnnssn_nsrnnssnWK;?i %gz3D8n`m %h]ĘQ`C_Uk!{w~}|~q|{%~K;?i %gz3D8n`m %h]ĘQ`Ӯ _ I\ø^ST]^ST]Opjkookko}K;?i %gz3D8n`m %h]ĘQ`v_kohlKoWSɩjtxpyytK;?i %gz3D8n`m %h]ĘQ`k~?T|ڠVXfI*Ćemozovnyw78eQs]J@ˋ*ۯ?g0D7.Y+&$_=Y:m-BE?%diñiwwv4Ok{|w~|~~"%~q %ϗњT"p}\'GωhDќ_-sdg(3qpldڕbbb %ijw|^9|4n/diñi01ckQQ2>%~q %ϗњT"p}\'GωhDќ_-sdg(3qpldڕbbb %ijw|^9|4n/diñiYk nrrnnssn_nsrnnssnq %ϗњT"p}\'GωhDќ_-sdg(3qpldڕbbb %ijw|^9|4n/diñiCU1ck!{w~}|~q|{%l~q %ϗњT"p}\'GωhDќ_-sdg(3qpldڕbbb %ijw|^9|4n/щww*qvk({|w~|~~"%~*|4n/i %`c䏦^^^^^^ %ijw|^щ0*k(QQ2>%F~*|4n/i %`c䏦^^^^^^ %ijw|^щ*k$ nrrnnssn(_nsrnnssnZ*|4n/i %`c䏦^^^^^^ %ijw|^щC*Uk(!{w~}|~q|{%~*|4n/i %`c䏦^^^^^^ %ijw|^vkohlKoWS ɩjtxp yyt*v8t/i %(RYQf՚ʙэfeffef %i`/%X"R.\opoopo %ifjwvk({|w~|~~"%~~Z?7 l1;=4Z M?F ޻l@ 4i`>(S:SQ #^œk(QQ2>%B~Z?7 l1;=4Z M?F ޻l@ 4i`>(S:SQ u~k$ nrrnnssn(_nsrnnssn`Z?7 l1;=4Z M?F ޻l@ 4i`>(S:SQ CjUk(!{w~}|~q|{%~Z?7 l1;=4Z M?F ޻l@ 4i`>(S:SQ vkohlKoWS ɩjtxp yytZ?7 l1;=4Z M?F ޻l@ 4i`>(S:SQ d>-pck$ Q#0b>5>(:CXAHuikՄ*!/N( SbS{݁͋'<!IS`<^ _ wwvk({|w~|~~"%~⋧荑^^^^^^ %i_x|^KeJKOD3܊㉓dddddd %iߋ{4z.v,r0c"iD?  00k(QQ2>%B~⋧荑^^^^^^ %i_x|^KeJKOD3܊㉓dddddd %iߋ{4z.v,r0c"iD?  3k$ nrrnnssn(_nsrnnssnL⋧荑^^^^^^ %i_x|^KeJKOD3܊㉓dddddd %iߋ{4z.v,r0c"iD?  CFUk(!{w~}|~q|{%~⋧荑^^^^^^ %i_x|^KeJKOD3܊㉓dddddd %iߋ{4z.v,r0c"iD? Ӊww븰vk({|w~|~~"%b~?@G~\\\\\\ %i؊n`Zl<~Zq4k&i %8$|8AՑefeeee %ixx}x|Ӊnk$ nrrnnssn(_nsrnnssn0?@G~\\\\\\ %i؊n`Zl<~Zq4k&i %8$|8AՑefeeee %ixx}x|>Yuk( Q#0b>5>(d:bI͋d u`[vYhyrzrrrU-r/syw4v {|w~|~~"%MǪ`R*cq#GxUpidSIDl *RѾĴd{H %B>-r/s2 QQ2>%MǪ`R*cq#GxUpidSIDl *RѾĴd{H %B>-r/s nrrnnssn _nsrnnssn MǪ`R*cq#GxUpidSIDl *RѾĴd{H %B>-r/sCU !{w~}|~q|{%(MǪ`R*cq#GxUpidSIDl *RѾĴd{H %B>-r/s  v ø^ST]^ST]OpjkookkoMǪ`R*cq#GxUpidSIDl *RѾĴb{H %B>-r/svohlKoWSɩjtxpyyt2MǪ`R*cq#GxUpidSIDl *RѾĴb{H %B>*k~6T|ڠVXfI*Ćemozovny$78wZMZ8V ]vWSR `ɶmPs`[@5z֍J(܈mhi*o%q=ᢱɠ_TusteC0=CmK]aPo,BZ i|tqPgaDFi͋*o<1 nrrnnssn_nsrnnssn =ᢱɠ_TusteC0=CmK]aPo,BZ i|tqPgaDFi͋*o%ensO~JzLk %^m㉫_$ nrrnnssn(_nsrnnssn ensO~JzLk %^m㉫C.U(!{w~}|~q|{%ensO~JzLk %^md#cv;ohlKoWSɩjtxpyytNe5mȉ~MT[uRzk %lhbٮqc< %\tCJAFmP_-2yw.vB({|w~|~~"%oB):[ G%M2)eثeASQ ?ha%-22Y(QQ2>%oB):[ G%M2)eثeASQ ?ha%-2E$ nrrnnssn(_nsrnnssn oB):[ G%M2)eثeASQ ?ha%-2CU(!{w~}|~q|{%oB):[ G%M2)eثeASQ ?ha%-2vohlKoWS ɩjtxp yyt2oB):[ G%M2)eثeASQ ?ha%b:>،Gu( Q#0b>5>QԹ|˄2g6ƿR|`|}r^Z[.,Y>ryWIWgM^_Yd)wgv'({|w~|~~"%gpppppp %keXj}jJvҢ̷{< %c]}prqqrq %k^baw+bR%`^d):g'(QQ2>%gpppppp %keXj}jJvҢ̷{< %c]}prqqrq %k^baw+bR%`^d)g $ nrrnnssn(_nsrnnssn gpppppp %keXj}jJvҢ̷{< %c]}prqqrq %k^baw+bR%`^d)CgU(!{w~}|~q|{%&gpppppp %keXj}jJvҢ̷{< %c]}prqqrq %k^baw+bR%`^Twwv {|w~|~~"%cs@,Zjmi~omu½llllkl %k{`x~v0XӂĔЌffffef %kdTw  nrrnnssn_nsrnnssn cs@,Zjmi~omu½llllkl %k{`x~v0XӂĔЌffffef %kd*>t( Q#0b>5>Qj)XVwzO72!KKKKKK $j"/$lΌ͌͊ $>k  endstream endobj 69 0 obj << /FontFile3 68 0 R /XHeight 705 /Ascent 745 /Type/FontDescriptor /Flags 98 /Descent -10 /CapHeight 690 /FontName/Melior-Italic /StemH 0 /FontBBox[-110 -255 1072 927] /ItalicAngle -12 /StemV 82 >> endobj 70 0 obj << /BaseFont/Melior-Italic /Type/Font /Subtype/Type1 /FirstChar 76 /Encoding 67 0 R /Widths[556 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 500 611 315 0 0 0 0 0 0 0 0 0 0 333] /LastChar 116 /FontDescriptor 69 0 R /Name/F13 >> endobj 71 0 obj << /BaseEncoding/MacRomanEncoding /Type/Encoding /Differences[32/space 37/percent 40/parenleft/parenright 44/comma/hyphen/period/slash/zero/one/two/three 53/five/six 65/A/B 68/D/E 72/H 75/K 77/M 79/O/P 83/S/T/U 97/a/b/c/d/e/f/g/h/i 108/l/m/n/o/p 114/r/s/t/u 119/w 121/y/z 181/mu] >> endobj 72 0 obj << /Subtype/Type1C /Length 19319 /Length1 19319 >> stream HelveticaNeue-LightCond4;`|3   FKXCopyright (c) 1990 Adobe Systems Incorporated. All Rights Reserved.Helvetica is a trademark of Linotype AG and/or its subsidiaries. The digitally encoded machine readable software for producing the Typefaces licensed to you is copyrighted (c) 1990 Adobe Systems. All Rights Reserved. This software is the property of Adobe Systems Incorporated and its licensors, and may not be reproduced, used, displayed, modified, disclosed or transferred without the express written approval of Adobe. The digitally encoded machine readable outline data for producing the Typefaces licensed to you is copyrighted (c) 1981 Linotype AG and/or its subsidiaries. All Rights Reserved. This data is the property of Linotype AG and/or its subsidiaries and may not be reproduced, used, displayed, modified, disclosed or transferred without the express written approval of Linotype AG and/or its subsidiaries. 12 Helvetica* 47 Light Condensed 49472 Helvetica 47 Light CondensedHelvetica Neue0Vw*\~'RHJ5R}A 4 & K l = n - m < \:`trsSrL*(\1tq@Qe1wcx%Ji0Y"~ $ ; x !7!_!!!" ""#/##$$$%9%&:&h&&''\'((a())8)r)*n*+R+h+,,--q-.:.//0=0011e1122A23#334d455676672778}9,9:;J=>>?'?]?@@u@ACAB5BCCvCD,DDED..vwp|vG^GvnnO*O>vv0vwnQ>w0:_mvvmvv0vYmvvYmv_w0>,UDwW^Vo LXf˳Փrm74X^BZ~-F8f*0g҃Y=WVf_VDJC$jqZ8`K{$$i! nj`amdYyi! nj`am6%d۹%%];;]d%%d۹%%];;]d%vvv˛7o-ĝ͋O_\y_.lӣU8w8wwe8**ewKe+55+eee+55e+e>v_:zzX]ЇAV\ _6>z ԿX-Gp[DO?K,;V? ղ֥4+J6>ŽU`OY/ H_C0`KFX7؞CK= سX97Z[6j>vJlwoJ8lOfOom>ǡELbğ?)UE66]KF"1=WQwWp>dZ?P>]'|s 4L@U`Bt~Ѳ\F100i1)*h>v V =WT,O">Ͻ`x`WC56^C11^K= b4ҝA#$@PHDy4b88ױذW?@fW>?e>dZ.*F>'|s\ 4N1Ԣ~[3)EdЈ|100h1*)i`#GGUoq{cɢG`GYvv~RcRc~Yv$Yv~~URcRctҽKxMƚ˜FP-ϷVDe}[eba^XU|kAhMG*qa"ǥlJ0=, Oq`u`\#&.0S³\v.F/VjC8a^<;qO6UVR)%HA",Y/$$1#22zR*vd&&&ddg^;*b (h,8Y\&U Y++UY KUX^3ӝUY R>X>1%M{{F* O%&9&7@d}}Xd@U E~|PE #btvvv]?|;V5+%M{{C5N&9&˾ڡz yUvw#^KK^fv^w^K4w`HVKdmEErK>v^wj4nG  Kt(w(KF"M"M""^"@@^K5- &&9&&9{7{{M7%%M{>v (b He6K7 QU-vv4xseBѵŢ9&&9&dtqnh%M{{7{|he*vQ cOefrrm2ꝭI iU V4-P]&> Y^ENB> h'K^1-[Kv C iһV3bv(RR(LDUL*4w\*M*K ]W--]KPw\SP^G33GӋP6  +^KAKPv^wdYLK.,GKX:bv^wRRU@G11GU@P66U-LL2)2vvwjvv-LL22Y)Yv{YY{Y^*vnnnMtSPt_v \V تsGMak@vkSE/QѣvyTzvcWNM,YTBWkʪǛbzv?w||Nd LKV I^gS~OTXªlXYSlONTYv sD.d^NSR\Pˬf8Q' I.L\=bzv?w||^O~^I V-KL- ʾțFXêlXYTlNOSYtuHuPD.d^LPU-EV I.L\=հ[-vu!u-Ƞy&|TBLBYbLOw]hUx\Q V-KhU½̞7-dXBV\O?U 'U|=ҵW=>aWDDa>bv?wdݺȩgB%T:LWkU|OfvwO0OfL-waAtyaY˾O0Ovvw_wN2Q4YAbSOfv^w^OvwSSݻjL!ݻjL!*ZAG`iPsdKP[pPoUbvwdݺȩgB%T:UWpPmUt[M. 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All Rights Reserved.Helvetica is a trademark of Linotype AG and/or its subsidiaries. The digitally encoded machine readable software for producing the Typefaces licensed to you is copyrighted (c) 1990 Adobe Systems. All Rights Reserved. This software is the property of Adobe Systems Incorporated and its licensors, and may not be reproduced, used, displayed, modified, disclosed or transferred without the express written approval of Adobe. The digitally encoded machine readable outline data for producing the Typefaces licensed to you is copyrighted (c) 1981 Linotype AG and/or its subsidiaries. All Rights Reserved. This data is the property of Linotype AG and/or its subsidiaries and may not be reproduced, used, displayed, modified, disclosed or transferred without the express written approval of Linotype AG and/or its subsidiaries. 12 Helvetica* 47 Light Condensed 49472 Helvetica 47 Light CondensedHelvetica Neue.Tu(Z|!L BD/Lw; . 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