In designed formulations for lyophilized drugs, it is important to know the collapse temperature of the cake. If the collapse temperature is exceeded, the cake will collapse and the batch will be ruined. The collapse temperature is often associated with the glass transition temperature (Tg) of the frozen material and measuring this transition is the best way to approximate it. It is also useful to know the amount of non-frozen water, which can be estimated as the enthalpy of melting (ΔH).
Read the application note to learn how both of these necessary values can be obtained with the 爱游戏平台注册登录 DSC 8500.