Along with the expression of the protein of interest, host cells release additional proteins (Host Cell Proteins, HCPs) into the supernatant which must be removed from drug products because they pose a risk of affecting drug quality, safety and efficacy.
The potential immunogenicity of biologics due to HCP contamination is a large risk, hence the need for accurate measurement to track the reduction of HCPs throughout the manufacturing process.
In this application note, you will learn: