Pulmonary Arterial Hypertension (PAH) is a life-threatening disease that affects the arteries in the lungs and the right side of the heart. Small animal models are often used in experimental PAH research due to their similarities to human cardiovascular physiology. MRI and microPET are established tools in evaluating RV function and physiology but both can present certain challenges including complex acquisition techniques, high imaging costs and accessibility. Conversely, microCT offers superior resolution, rapid data acquisition, and ease-of-use. Read this editorial and article published in the December issue of Circulation on how researchers report on the first quantitative assessment of RV and left ventricular systolic and diastolic volumes and function in an experimental model of PAH using the Quantum GX2 microCT imaging system.