Legacy methods, by their very nature, often use older column technologies. These older phases can be accompanied by larger variations in batch-to-batch performance which can lead to inconsistent results and cause out of specification (OOS) occurrences. With routine analysis, often completed with compliant procedures, any unplanned downtime to investigate OOS instances can impact productivity. Our range of clone phases offer a cost-effective comparable alternative to many of the older leading brands, whilst ensuring consistency and stability in analysis. Better lot-to-lot reproducibility is also achieved due to more stable production methods especially when compared to older brands. Our Aviator™ line exhibits similar selectivity to Avantor ACE® HPLC columns. Aviator C18 provides a rugged, reproducible starting point for method development and applications with analytes differing in hydrophobicity, polar, moderately polar and non-polar analytes, uncharged acids and bases, and ionized acids or bases using ion-pairing. Other Aviator phases are also available including AQ, C8, C4, Cyano and Phenyl. This technical note provides examples of comparative studies between the Aviator C18 (150 x 4.6 mm, 5 µm) column and the ACE C18 (150 x 4.6 mm, 5 µm) column, for the following pharmaceutical drug applications: