Legacy methods, by their very nature, often use older column technologies. These older phases can be accompanied by larger variations in batch-to-batch performance which can lead to inconsistent results and cause out of specification (OOS) occurrences. With routine analysis, often completed with compliant procedures, any unplanned downtime to investigate OOS instances can impact productivity. Our range of clone phases offer a cost-effective comparable alternative to many of the older leading brands, whilst ensuring consistency and stability in analysis. Better lot-to-lot reproducibility is also achieved due to more stable production methods especially when compared to older brands. Our Sonoma™ line is an alternative to Phenomenex Luna®. Excellent efficiencies, peak shape and resolution are obtained for virtually all Luna HPLC applications from high quality Sonoma HPLC columns. A range of particle sizes offers versatility from analytical and LC/MS to prep and process scale applications. Sonoma C18(2), the most popular phase, is equivalent to Luna C18(2). Available in 3 µm and 5 µm particle sizes, with bulk and preparative material available. Other Sonoma phases available include C18, C5, C8, C8(2), Cyano, HILIC, NH2 (amino), PFP(2), Phenyl-Hexyl and Silica(2). This technical note displays examples of comparative studies between our Sonoma C18(2) (150 x 4.6 mm, 5 µm) column and the Phenomenex Luna C18(2) (150 x 4.6 mm, 5 µm) column, for the following pharmaceutical drug applications: