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Life Sciences & Diagnostics and Analytical & Enterprise Solutions
Capillary electrophoresis (CE), more specifically CE-SDS, is becoming an increasingly popular and routinely used method for monitoring and documenting critical quality attributes for monoclonal antibody therapeutic products, due to its automated operation, on-column detection, great resolving power, and protein quantification capability. Such characterization is frequently used in the development and manufacture of biopharmaceutical products, to meet FDA documentation requirements.
The LabChip GXII Touch Biologics Characterization System features microfluidic CE-SDS (µCE-SDS) technology for analytical characterization of biopharmaceutical products. It offers an automated alternative to traditional SDS-PAGE methods, by streamlining the multiple, manual steps of slab gel electrophoresis, while providing the throughput and data quality essential to biotherapeutic workflows.
In this application note, the characterization of a reference monoclonal antibody from the National Institute of Standards and Technology (NIST) using the LabChip GXII Touch is compared to those published by NIST using the SCIEX® PA-800 Plus system.