The solvents in the inks used to print flexible packaging may represent a possible source of food contamination and therefore must be controlled for quality and consumer safety. For the determination of residual solvents from printed materials, it is highly recommended that an analytical method such as the official UNI EN 13628-2:20041 is followed. This Application Note describes how GC (Gas Chromatography) analytical techniques can be used to determine the presence and quantity of residual solvents using the Clarus 580 GC / TurboMatrix Headspace system for swift and simple sample preparation and accurate analytical results.