Multifunctional mRNA-Based CAR T-Cells Show Promising Anti-Tumor Activity Against Glioblastoma

Glioblastoma is the most common type of malignant brain tumor in adults. It is usually very aggressive, with less than 10% of patients expected to survive five years following diagnosis. Traditional treatment strategies are rarely curative, emphasizing the urgent need to discover more effective therapies for this type of cancer.

Read this publication review to learn how researchers have evaluated the efficiency of mRNA-based multifunctional CAR T-cells against glioblastoma in vitro and in vivo. The authors confirm rationale for future clinical studies using this type of therapy to treat malignant brain tumors.

• Use of high-content screening (using the Opera Phenix^®) to characterize mRNA-modified T-cells in complex glioblastoma patient samples.
• Use of fluorescence molecular tomography in glioblastoma mouse models.