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8-hydroxy-2-(di-n-propylamino)tetralin (8-OH-DPAT) is a highly selective full agonist of the 5-HT1A receptor that also stimulates the 5-HT7 receptor and has been shown to label 5-hydroxytryptamine (5-HT) reuptake sites. These receptors are part of a group of serotonin G-protein coupled receptors (GPCRs) found in the central and peripheral nervous systems, and modulate the release of neurotransmitters and hormones. 5-HT receptors are the pharmacological target of many antidepressants, antipsychotic, anti-migraine, and other pharmaceutical drugs.
We offer both agonist and antagonist radioligands for autoradiographic visualization or performing saturation and competition assays to determine receptor expression levels (Bmax), dissociation constants (Kd), association and dissociation rates (kon and koff), and inhibitor constants (Ki) for a variety of receptors. We develop our radioligands to the highest specific activity possible and provide high purity resulting in low non-specific binding products. Each of our ultra-pure radioligands is fully characterized for pharmacological action and validated in receptor binding assays.
Radiolabeled ligands remain the most sensitive method for probing receptor binding biology; yielding unprecedented sensitivity gives results that technicians and scientists can trust. For over 50 years, 爱游戏平台注册登录 has been a leading supplier of New England Nuclear (NEN) radiochemicals, liquid scintillation cocktails, vials and nuclear counting detection instruments.
References for NET929:
Label Position | Specifically Labeled |
---|---|
Molecular Weight | 247.4 |
Product Brand Name | NEN Radiochemicals |
Radioisotope | H-3 |
Radionuclide | 3H |
Receptor Type | 5-Hydroxytryptamine |
Shipping Condition | Dry Ice |
Special Ordering Information | This is a radioactive product - shipping address must have a license to receive radioactive materials. |
Therapeutic Area | CNS & Neurologic |
Unit Size | 1 mCi |
For over 50 years 爱游戏平台注册登录 has been a leading supplier of radiochemicals, liquid scintillation cocktails, vials and nuclear counting detection instruments. Today is no different. We have always been committed to providing you products for all of your radiometric needs and we are still committed t ...