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Focal adhesion kinase (FAK), also known as protein tyrosine kinase 2 (PTK2), is a non-receptor tyrosine kinase that can be activated by growth factor receptors, cytokine receptors, and GPCRs. FAK is a central regulator of ECM/integrin and cadherin signaling and plays a role in cell adhesion, cell junction, migration, survival, and mechanosensing. Increased FAK expression and phosphorylation is implicated in increased tumor cell adhesion, tumor cell motility and invasion, and with fibroblast migration on fibronectin in tissue fibrosis.
The AlphaLISA SureFire Human and Mouse Phospho-FAK (Tyr397) Detection Kit is a sandwich immunoassay for the quantitative detection of phospho-FAK (Tyr397) in cellular lysates, using Alpha Technology.
Assay Target | FAK |
---|---|
Assay Technology | Alpha |
Automation Compatible | Yes |
Detection Method | Alpha |
Experimental Type | In vitro |
Product Brand Name | AlphaLISA SureFire Ultra |
Shipping Condition | Blue Ice |
Target Species | Human, Mouse |
Therapeutic Area | Oncology |
Unit Size | 10,000 Assay Points |
The introduction of enzyme-linked immunosorbent assays (ELISAs) in the early 1970’s offered researchers a non-radiometric immunoassay platform without compromising sensitivity. Over the last 50 years scientists have made huge strides in disease research and drug discovery and a demand for greater ...
Product brochure for the Alpha Technology, a versatile, no wash, homogeneous assay technology that's suitable for a broad range of applications.
Find out about our range of integrated solutions for drug discovery screening in this e-brochure.
Our screening solutions for high-throughput screening, phenotypic screening and data analysis help to streamline drug discovery workflows in labs across the globe. Our portfolio includes automat ...