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Histone Deacetylase 5 (HDAC5) is an enzyme and class II HDAC responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation indicates epigenetic repression and is involved in transcriptional regulation, cell cycle progression, and developmental events. Mutations in HDAC expression are strongly associated with loss of tumor protection genes. HDAC mutations are associated with breast cancer, hepatocellular carcinoma (HCC), lung cancer, pancreatic neuroendocrine cancer, and colorectal cancer.
The AlphaLISA SureFire Human and Mouse Total HDAC5 Detection Kit is a sandwich immunoassay for the quantitative detection of total HDAC5 in cellular lysates, using Alpha Technology.
Assay Target | HDAC5 |
---|---|
Assay Technology | Alpha |
Automation Compatible | Yes |
Detection Method | Alpha |
Experimental Type | In vitro |
Product Brand Name | AlphaLISA SureFire Ultra |
Shipping Condition | Blue Ice |
Target Species | Human, Mouse |
Therapeutic Area | Oncology |
Unit Size | 50,000 Assay Points |
The introduction of enzyme-linked immunosorbent assays (ELISAs) in the early 1970’s offered researchers a non-radiometric immunoassay platform without compromising sensitivity. Over the last 50 years scientists have made huge strides in disease research and drug discovery and a demand for greater ...
Product brochure for the Alpha Technology, a versatile, no wash, homogeneous assay technology that's suitable for a broad range of applications.
Find out about our range of integrated solutions for drug discovery screening in this e-brochure.
Our screening solutions for high-throughput screening, phenotypic screening and data analysis help to streamline drug discovery workflows in labs across the globe. Our portfolio includes automat ...