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Total IRF3 AlphaLISA SureFire Ultra Detection Kit, 10,000 Assay Points

The AlphaLISA® SureFire® Ultra™ Total IRF3 assay is a sandwich immunoassay for quantitative detection of total IRF3 in cellular lysates using Alpha Technology.

This kit has been pre-validated for use in combination with Pelago Bioscience’s CETSA® (Cellular Thermal Shift Assay) technology. Please note that further assay optimization will be required in order to adapt the kit to your particular cell line and experimental conditions. A valid CETSA® licence from Pelago Bioscience or a single kit agreement is required for using the CETSA® technology.

For research use only; not for diagnostic procedures. All products to be used in accordance with applicable laws and regulations including without limitation, consumption & disposal requirements under European REACH regulations (EC 1907/2006).

Part Number
Unit Size
List Price
Your Price
Quantity
ALSU-TIRF3-A500
500 Assay Points
2236.00 USD
 
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ALSU-TIRF3-A10K
10,000 Assay Points
13600.00 USD
 
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ALSU-TIRF3-A50K
50,000 Assay Points
43900.00 USD
 
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ALSU-TIRF3-A-HV
100 Assay Points
662.00 USD
 
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Overview

Interferon regulatory factor 3 (IRF3) is a part of the IRF family which is involved in the regulation of interferon α and β and play a role in host anti-viral immune regulation, cell growth, and hematopoietic development. In viral infected cells, phosphorylation of transcription factor IRF3 induces the production of antiviral and proinflammatory cytokines, a key element in the type 1 interferon-independent innate immune response. IRF3 is activated downstream of the STING signaling pathway and toll-like receptor signaling pathway. IRF3 is associated with cancer and autoinflammatory disease. 

The AlphaLISA SureFire Ultra Total IRF3 assay is a sandwich immunoassay for the quantitative detection of total IRF3 in cellular lysates, using Alpha Technology.

Formats:

  • The HV (high volume) kit contains reagents to run 100 wells in 96-well format, using a 60 μL reaction volume.
  • The 500-point kit contains enough reagents to run 500 wells in 384-well format, using a 20 μL reaction volume.
  • The 10,000-point kit contains enough reagents to run 10,000 wells in 384-well format, using a 20 μL reaction volume.
  • The 50,000-point kit contains enough reagents to run 50,000 wells in 384-well format, using a 20 μL reaction volume.

AlphaLISA SureFire Ultra kits are compatible with:

  • Cell and tissue lysates
  • Antibody modulators
  • Biotherapeutic antibodies

Alpha SureFire kits can be used for:

  • Cellular kinase assays
  • Receptor activation studies
  • Screening

Specifications

Assay Target IRF3
Assay Technology Alpha
Automation Compatible Yes
Detection Method Alpha
Experimental Type In vitro
Product Brand Name AlphaLISA SureFire Ultra
Shipping Condition Blue Ice
Therapeutic Area Autoimmunity, Oncology
Unit Size 10,000 Assay Points
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Application Brief

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Brochure

Alpha Technology Solutions

Product brochure for the Alpha Technology, a versatile, no wash, homogeneous assay technology that's suitable for a broad range of applications.

PDF 2 MB
Drug Discovery Screening Solutions Brochure

Find out about our range of integrated solutions for drug discovery screening in this e-brochure.

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