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Total MLKL (mouse) Alpha SureFire Ultra Detection kit, 500

The AlphaLISA® SureFire® Ultra Total MLKL assay (mouse) is a sandwich immunoassay for quantitative detection of total MLKL in cellular lysates using Alpha Technology.

For research use only; not for diagnostic procedures. All products to be used in accordance with applicable laws and regulations including without limitation, consumption & disposal requirements under European REACH regulations (EC 1907/2006).

Part Number
Unit Size
List Price
Your Price
Quantity
ALSU-TMLKL-B500
500 Assay Points
2236.00 USD
 
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ALSU-TMLKL-B10K
10,000 Assay Points
13600.00 USD
 
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ALSU-TMLKL-B50K
50,000 Assay Points
43900.00 USD
 
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ALSU-TMLKL-B-HV
100 Assay Points
706.00 USD
 
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Overview

Mixed lineage kinase domain-like protein is encoded by the MLKL gene in murine species. This protein plays a critical role in tumor necrosis factor (TNF)-induced necroptosis, a programmed cell death process, via interaction with receptor-interacting protein 3 (RIP3) key signaling molecules in the necroptosis pathway. Inhibitor studies and knockdown of this gene inhibit TNF-induced necrosis. High levels of this protein and RIP3 are associated with inflammatory bowel disease in children.

The AlphaLISA® SureFire® Ultra total mouse MLKL assay is a sandwich immunoassay for the quantitative detection of mouse MLKL (phosphorylated and non-phosphorylated) in cellular lysates, using Alpha Technology. This assay is intended to be used for normalization phosphorylation studies.

Formats:

  • The HV (high volume) kit contains reagents to run 100 wells in 96-well format, using a 60 μL reaction volume.
  • The 500-point kit contains enough reagents to run 500 wells in 384-well format, using a 20 μL reaction volume.
  • The 10,000-point kit contains enough reagents to run 10,000 wells in 384-well format, using a 20 μL reaction volume.
  • The 50,000-point kit contains enough reagents to run 50,000 wells in 384-well format, using a 20 μL reaction volume.

AlphaLISA SureFire Ultra kits are compatible with:

  • Cell and tissue lysates
  • Antibody modulators
  • Biotherapeutic antibodies

Alpha SureFire kits can be used for:

  • Cellular kinase assays
  • Receptor activation studies
  • Screening

Specifications

Assay Target MLKL
Assay Technology Alpha
Automation Compatible Yes
Detection Method Alpha
Experimental Type In vitro
Product Brand Name AlphaLISA SureFire Ultra
Shipping Condition Blue Ice
Therapeutic Area Neuroinflammation, Oncology, Inflammation
Unit Size 500 Assay Points
Resources, Events & More
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Application Brief

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Brochure

Alpha Technology Solutions

Product brochure for the Alpha Technology, a versatile, no wash, homogeneous assay technology that's suitable for a broad range of applications.

PDF 2 MB
Drug Discovery Screening Solutions Brochure

Find out about our range of integrated solutions for drug discovery screening in this e-brochure.

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