For research use only; not for diagnostic procedures. All products to be used in accordance with applicable laws and regulations including without limitation, consumption & disposal requirements under European REACH regulations (EC 1907/2006).
VAV1 is a Rho-family guanine nucleotide exchange factor that is encoded by a proto-oncogene, Vav Guanine Nucleotide Exchange factor 1. Wild-type VAV1 is recognized as a cardinal signal transducer protein in the hematopoietic system, where it is exclusively expressed. However, mutations in various domains of the VAV1 protein are present in human cancers, including T-cell leukemia/lymphoma, peripheral T-cell lymphomas, lung adenocarcinoma, and squamous cell carcinomas. VAV1 is also an activator of T and B cell receptor signaling, therefore making it a potential target for protein degradation therapies to combat autoimmune disease, such as multiple sclerosis.
The AlphaLISA SureFire Human Phospho-VAV1 (Tyr174) Detection Kit is a sandwich immunoassay for the quantitative detection of phospho-VAV1 (Tyr174) in cellular lysates, using Alpha Technology.
檢測目標 | VAV1 |
---|---|
檢測技術 | Alpha |
自動化兼容 | Yes |
檢測方法 | Alpha |
實驗類型 | In vitro |
產品品牌名稱 | AlphaLISA SureFire Ultra |
運輸條件 | 藍冰 |
Target Species | Human |
治療領域 | Oncology, Immuno-oncology |
產品尺寸 | 50,000 Assay Points |
Find out about our range of integrated solutions for drug discovery screening in this e-brochure.
Our screening solutions for high-throughput screening, phenotypic screening and data analysis help to streamline drug discovery workflows in labs across the globe. Our portfolio includes automat ...
Product brochure for the Alpha Technology, a versatile, no wash, homogeneous assay technology that's suitable for a broad range of applications.
The introduction of enzyme-linked immunosorbent assays (ELISAs) in the early 1970’s offered researchers a non-radiometric immunoassay platform without compromising sensitivity. Over the last 50 years scientists have made huge strides in disease research and drug discovery and a demand for greater ...