Chromium-51 (51Cr) radionuclide, commonly used as a label for target cells in chromium release assays, cell-mediated cytotoxicity studies, antibody-dependent cytotoxicity (ADCC) studies, and CAR-T cell development. Target cells uptake 51Cr radionuclide, and release the nuclide into the culture media upon cytolysis or cell death.
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Chromium-51 is the most commonly used readioactive marker for the labeling of target cells in cytotoxicity assays. The common name for such assays Chromium Release also describes the fundamental method behind the assay procedure. Methods for the precise and accurate quantification of cytotoxicity are of fundamental importance in immunology particularly for the study of tumor and virus cytolysis.
Cytotoxicity assays can be used in order to study either the defense mechanism in a specific patient or to study target cells, depending on whether the effector (or killer) cells are the unknowns. It can also be used for the study of certain drugs on the immune system.
Chromium fulfills the requirement of a good label. It is generally non-toxic (as Na2CrO4), it is easily taken up by the cells, it is spontaneously released only in relatively small amounts, its detection is easy and sensitive and it does not change the morphology and characteristics of the target cell.
| 檢測方法 | Radiometric |
|---|---|
| 新鮮的很多天 | Every other Friday |
| 半衰期 | 27.71 days |
| 標簽位置 | Specifically Labeled |
| 產品品牌名稱 | NEN Radiochemicals |
| 放射性同位素 | Cr-51 |
| 放射性核素 | 51Cr |
| 運輸條件 | 環境 |
| 特殊訂購信息 | This is a radioactive product - shipping address must have a license to receive radioactive materials. |
| 產品尺寸 | 2 mCi |
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This document contains general information designed to provide a basic understanding of radiation safety. While we believe the information to be accurate, regulatory requirements may change and information contained herein is not tailored to individual needs.
This document contains general information designed to provide a basic understanding of radiation safety. While we believe the information to be accurate, regulatory requirements may change and information contained herein is not tailored to individual needs.
