爱游戏平台注册登录
check quantity

Cyclopentyl-1,3-Dipropylxanthine, 8-[Dipropyl-2,3-3H(N)]-, 1mCi (37MBq)

8-Cyclopentyl-1,3-dipropylxanthine (DPCPX, PD-116,948), tritiated at the dipropyl-2,3- positions. DPCPX acts as a potent and selective antagonist for the adenosine A1 receptor.

貨號
產品尺寸
NET974250UC
250 µCi
更多
NET974001MC
1 mCi
更多
Request Technical Support

請輸入有效數量

請登錄以添加收藏夾。

購物車為空

詳細信息

8-Cyclopentyl-1,3-dipropylxanthine (DPCPX, PD-116,948) acts as an antagonist at the adenosine A1 receptor. This receptor is part of a group of adenosine GPCRs, is implicated in sleep promotion and breathing, and is a potential drug target for sleep apnea.

We offer both agonist and antagonist radioligands for autoradiographic visualization or performing saturation and competition assays to determine receptor expression levels (Bmax), dissociation constants (Kd), association and dissociation rates (kon and koff), and inhibitor constants (Ki) for a variety of receptors. We develop our radioligands to the highest specific activity possible and provide high purity resulting in low non-specific binding products. Each of our ultra-pure radioligands is fully characterized for pharmacological action and validated in receptor binding assays.

Radiolabeled ligands remain the most sensitive method for probing receptor binding biology; yielding unprecedented sensitivity gives results that technicians and scientists can trust. For over 50 years, 爱游戏平台注册登录 has been a leading supplier of New England Nuclear (NEN) radiochemicals, liquid scintillation cocktails, vials and nuclear counting detection instruments.

References for NET974:

  1. Schetz, J. A. and Sibley, D. R. (1997), Zinc Allosterically Modulates Antagonist Binding to Cloned D1 and D2 Dopamine Receptors. Journal of Neurochemistry, 68: 1990–1997.
  2. Qinye Dong, Jennifer Schuchman, Gale B. Carey, Characterization of the swine adipocyte A1 adenosine receptor using an optimized assay system, In Comparative Biochemistry and Physiology Part C: Pharmacology, Toxicology and Endocrinology, Volume 108, Issue 3, 1994, Pages 269-280.

規格

檢測方法 Radiometric
標簽位置 Nominally Labeled
分子量 305.4
產品品牌名稱 NEN Radiochemicals
放射性同位素 H-3
放射性核素 3H
受體類型 Adenosine
運輸條件 幹冰
特殊訂購信息 This is a radioactive product - shipping address must have a license to receive radioactive materials.
治療領域 CNS & Neurologic, Cardiovascular, Inflammation
產品尺寸 1 mCi
資源
  • 所有

產品手冊

Radiometric Reagents Guide 2010-2011

For over 50 years 爱游戏平台注册登录 has been a leading supplier of radiochemicals, liquid scintillation cocktails, vials and nuclear counting detection instruments. Today is no different. We have always been committed to providing you products for all of your radiometric needs and we are still committed t ...

PDF 2 MB
Baidu
map