Guanosine 3',5'-Cyclic Phosphate, Ammonium Salt, [8-³H]-, 1 mCi (37 MBq)

Radiochemical Purity is >96%

250 µCi quantities of [8-3H]-Guanosine 3',5'-Cyclic Phosphate (cGMP), Ammonium Salt, are available for your research.  Application of [3H]cGMP can be found in:  binding domains of a specific phosphodiesterase in cellular signalling, interactions of mefloquine with ABC proteins (MRP1 and MRP4) in biochemical pharmacology, expression and localization of the multidrug resistance protein 5 (MRP5/ABCC5) in pharmacology, etc.

Special Information:

• CONVERSION TO OTHER SALTS: The ammonium salt may be converted to that of another cation by passing it through a small column of exchange resin in the form the desired cation. A 1-2mL quantity of thoroughly washed resin is generally satisfactory. Necessary precautions should be exercised to minimize any breakdown from occurring during this procedure.
• Removal of Solvent: An aliquot or the entire sample can be taken to dryness by directing a gentle stream of inert gas (nitrogen) over the surface of the solution. The temperature of the solution should not be allowed to exceed 20°C during the drying process, and the compound should not be permitted to remain in the solid state any longer than necessary.