The detection of compound cytotoxicity is an essential part of drug discovery. In this work we describe a rapid and flexible image-based live cell approach to study cytotoxicity. Based on the use of a fluorophore dye mixture, we analyzed multiple cellular phenotypic changes following a toxic insu ...

Mitochondrial dynamics are essential for energy conversion and neuron survival. Understanding changes in mitochondrial dynamics is therefore crucial in developing mitochondria-based therapy options for complex pathological conditions such as cancer, neurological disorders, and metabolic syndromes ...

Analyzing transport of biliary metabolites is essential to predict pharmacokinetics and hepatotoxicity during drug development. A functional impairment of hepatobilary transporters, such as bile salt export pump (BSEP) and multidrug resistance-associated protein 2 (MRP-2), is strongly associated wit ...

Drug-induced cardiotoxicity is a frequent cause of drug attrition during drug development and can lead to the withdrawal of drugs from the market, so non-invasive approaches that allow quick and reliable assessment of the cardiotoxic potential of a compound are key to improve drug safety.

I ...

Fundamental processes in living cells, such as apoptosis and signal transduction are controlled by proteins, often acting in concert with other protein partners through protein-protein interactions (PPIs). Inappropriate protein-protein recognition can fundamentally contribute to many diseases, inclu ...

With powerful potential for phenotypic drug discovery, cell painting is being rapidly adopted by leading scientists across the globe. However, implementing cell painting assays can present some challenges.

To help you avoid some of the common pitfalls, we’ve collated answers from our expert ...

Download our brochure to learn how our solutions help you to grow, detect, and analyze 3D cells.

The product of more than a decade of experience in high-content screening, the Operetta CLS delivers the speed and sensitivity for everyday assays, and even complex challenges – live cells, phenotyping, rare events, and much more.

Infectious diseases remain a major burden to human health. The increased globalization of modern society that facilitates the spread of infectious diseases, and phenomena such as anti-microbial resistance, underscore the importance of the development of new preventative and therapeutic approaches ...

This guide provides instructions on how to find help and manuals for your HCS Hardware/Software (Opera Phenix Plus, Operetta CLS, Harmony).

Download our technical note to find out how you can overcome some of the challenges associated with long-term live cell imaging. Learn how you can perform successful five-day live cell imaging on Operetta CLS™ and Opera Phenix™ high-content systems, avoid phototoxicity with gentle digital phase cont ...

The Opera Phenix™ high-content screening system’s state of the art hardware, combined with Harmony® imaging and analysis software, improves acquisition and analysis speed, enabling users to perform highly multi-parametric phenotypic screens effectively. In this technical note, learn how the Opera P ...

There has been a lot of buzz around artificial intelligence, machine learning and deep learning. Is the reality living up to the hype?

In the world of cellular imaging and its application to drug discovery, there is evidence of real progress against some of the critical challenges facing s ...

Researchers are increasingly looking to 3D cell cultures, microtissues, and organoids to bridge the gap between 2D cell cultures and in vivo animal models. This whitepaper documents a streamlined procedure for getting the most information, as quickly as possible, using solutions from 爱游戏平台注册登录 .