Human IL12/IL12Rβ1 binding kit, 500 Tests

Also known as NKSF (natural killer cell stimulatory factor) and CLMF (cytotoxic lymphocyte maturation factor), IL12 is produced by macrophages and B cells. Along with IFN gamma, IL12 promotes the differentiation of naïve T cells into TH1 cells, which in turn release IFNg and IL2. Because of its effects on TH1 induction, IL12 is strongly linked to autoimmunity. IL12 is a heterodimer of p35 and p40 which binds the heterodimeric IL12Rβ1 , IL12Rβ2 complex.

The Human IL12/IL12Rβ1R assay is highly specific for IL12/IL12Rβ1 and hence is especially suitable for the discovery and characterization of anti p40 antibodies.