Human IL23/IL12Rβ1 binding kit, 10000 Tests

IL23 is part of the response against infection, as it upregulates the expression of MMP9 (matrix metalloprotease 9), increases angiogenesis, and reduces CD8 T cell infiltration into tumors. In oncology and immuno-oncology, IL23 has been studied for its effects on T cell infiltration and its promotion on TH17 cell development. Anti IL23 antibodies have also been developed for the threatment of Crohn's Disease and psoriasis. IL23 is a heterodimeric cytokine composed of p19 and p40 subunits, and which binds the heterodimeric IL23R, IL12Rβ1 complex. The Human IL23 / IL12Rβ1 assay is highly specific for IL23 / IL12Rβ1, and hence is especially suitable for the discovery and qualification of anti p40 antibodies.