Phospho-SMAD2 (Ser465/467) cellular kit, 500 Tests

This HTRF cell-based assay enables the rapid, quantitative detection of SMAD2 phosphorylated at Serine 465/467, as a readout of TGF-ß signaling activity.

TGF-ß receptors directly activate SMAD2 by phosphorylation at Ser465/467, causing it to translocate to the nucleus and regulate gene expression involved in apoptosis, migration, and differentiation, as well as in immune/inflammatory responses and extracellular matrix remodeling.