Researchers trust our in vivo imaging solutions to give them reliable, calibrated data that reveals pathway characterization and therapeutic efficacies for a broad range of indications. Our reagents, instruments, and applications support have helped hundreds of research projects over the years. And ...

Scientists continue to explore several options to treat SARS-CoV-2 infection with hundreds of therapeutics at various phases of development. At the start of the pandemic, several factors hampered the rapid identification of potential SARS-CoV-2 therapeutics, including a limited understanding of t ...

A large percentage of Type 2 diabetes mortality is related to cardiovascular complications. Consequently, there is a critical need for creating novel therapeutics that not only manage blood glucose levels, but also reduce the risk of developing cardiovascular diseases.

Liraglutide (Lira) is ...

Surfactant Protein B (SP-B) deficiency is an uncommon, autosomal recessive lung disorder in term infants. This inability to produce SP-B leads to progressive, lethal, hypoxemic respiratory failure in the first year of life. The current standard of care is a lung transplant although rare due to av ...

Adoptive cell transfer using chimeric antigen receptor (CAR-T) cell therapy in which the patient’s T-cells are extracted, genetically modified, and transferred back into the patient with the aim that these altered cells can recognize and attack cancer cells has revolutionized cancer immunotherapy ...

Influenza is a highly infectious airborne disease with an important societal burden. Annual epidemics have occurred throughout history causing tens of millions of deaths. Even a run-of-the-mill influenza infection can be debilitating to otherwise healthy people, and lethal to those who are elderl ...

It’s simple: More information means more understanding,For today’s researchers in oncology, infectious diseases, inflammation, neuroscience, stem cells,and other disciplines, there’s an increasing need for in vivo imaging that enables you to visualize,multiple events simultaneously and to extract th ...

Our comprehensive range of bioluminescent and fluorescent imaging reagents provide researchers with the necessary tools to better understand early disease-related biological changes, track disease progression, help guide the drug discovery process, and evaluate efficacy and safety of drug candida ...

IVIS SPECTRUM CT，In Vivo Imaging,，microCT，小動物活體光學成像，小動物活體光學三維成像，小動物活體三維多模式成像，光學/CT一體機，功能與結構成像

The IVIS® SpectrumCT expands upon the versatility,and advanced optical feature sets of the IVIS and,Maestro™ platforms integrated with low dose,microCT to support longitudinal imaging. The IVIS,SpectrumCT enables simultaneous molecular and,anatomical longitudinal studies, providing researchers,with ...

Fluorescence molecular imaging is the visualization of cellular and biological function in vivo to gain deeper insights into disease processes and treatment effects. Designing an effective study from the beginning can help save time and resources.

Learn about several important best p ...

Aside from the traditional small-molecule chemotherapeutics or targeted therapy agents that have been widely used in the clinic for decades, a new type of cancer therapeutics based on oncolytic viruses has recently gained attention in the field of research. Oncolytic viruses are genetically modif ...

Drug induced liver injury (DILI) is a major reason for late stage termination of drug discovery research projects, highlighting the importance of early integration of liver safety assessment in the drug development process. A technical approach for in vivo toxicology determination was developed usin ...

Epifluorescence (2D) imaging of superficially implanted mouse tumor xenograft models offers a fast and simple method for assessing tumor progression or response to therapy. This approach for tumor assessment requires the use of near infrared (NIR) imaging agents specific for different aspects of tum ...

Cerenkov Emission from radioisotopes in tissue,Optical imaging detects photons in the visible range of the electromagnetic,spectrum. PET and SPECT imaging instruments are sensitive to photons in the much,higher energy range of x-rays and gamma rays. While the PET and SPECT probes,which can generate ...

In order to facilitate faster transillumination imaging, with Living Image 4, we have incorporated raster scanning capabilities. With raster scanning, the shutter remains open as the transillumination excitation source moves underneath the animal. This results in a single image and faster imaging ti ...

Acquisition of High Resolution Images. This quick reference guide is for those researchers who wish to perform analysis that requires high resolution including in vitro studies when one may want to discern aspects about cell layers, ex vivo tissue imaging, or imaging of tissue slices. You will not ...

It is possible to copy 3D sources (voxels) from one 3D reconstruction into another. For example, superimposing DLIT or FLIT signals is easy. However, the two combined sources must be based upon the same surface topography to produce meaningful information. Therefore it is imperative that the mouse r ...

For many studies, it may be desirable to open a group of images together, for example, analyzing multiple days of longitudinal study side by side using the same scale.

Transillumination is a 2D fluorescence imaging technique that utilizes an excitation light source located below the stage. Transillumination is superior to epi-illumination at detection of red-shifted, deep tissue fluorescent sources due to the transilluminator’s concentrated delivery of excitation ...

This guide will walk you through the steps of manually entering your sequences for the spectral unmixing procedure. The Living Image 4.3.1 software version includes an Autoexposure setting and an Imaging Wizard. For questions on how to use these two features please see the respective quick reference ...

Acquiring the most accurate quantitation of your bioluminescent sources requires a close understanding of the underlying kinetics involved in producing and capturing the detected light. After injection, the substrate for your bioluminescent probe will di

Normalized transmission fluorescence is a technique that allows us to subtract background light leakage through thin tissue from transillumination images utilizing an extra image captured with a neutral density (ND) filter. The ND filter dampens the intensity of the halogen lamp to 1/100th of the so ...

Subject ROI using IVIS imaging systems

Not only is it possible to load multiple images as a group, for example multiple days of a longitudinal study, but it is also possible to load multiple images and Overlay them i.e. bioluminescent tumor with fluorescent targeted drug acquired in two separate images.

Working with Image Math. Image Math is a rudimentary but effective method for Spectrum and Lumina users to subtract background from images without performing Spectral Unmixing.

Fluorescence Tomography – Source Reconstruction and Analysis - FLIT Reconstruction

The goal of in vivo fluorescence molecular imaging is to enable non-invasive visualization and quantification of cellular and biological functioning to better understand and characterize disease processes and treatment effects earlier within the context of a biological system.

This s ...

This IVIS^® SpectrumCT user manual provides the technical requirements and specifications of the IVIS SpectrumCT, and provides you with the tools to seamlessly setup and maintain your system.

The IVIS SpectrumCT preclinical in vivo imaging system expands upon the vers ...

CAR T therapy has achieved tremendous success in treating blood malignancies, however treating solid tumors with this therapy has proven to be challenging due to several factors such as on-tumor, off-tumor toxicity.

Read this case study where researchers from University of Pennsylvania crea ...

Obesity is a global epidemic that is the fifth leading cause of death worldwide and in the US alone, nearly 85% of adults are expected to be overweight or obese by 2030. In addition to the increased risk of overall mortality, obesity is associated with an increased risk for other metabolic disord ...

Epstein-Barr virus (EBV) is one of the most common human viruses found throughout the world. The majority of infections lead to benign latent EBV infection in B-lymphocytes. However, in some patients it induces B-cell transformation causing lymphoid malignancies such as Burkitt and Hodgkin’s lymp ...

Non-alcoholic fatty liver disease (NAFLD) describes a progressive pathology that affects the liver. Fat accumulation causes fatty liver (NAFL) or steatosis to develop, which leads to lipotoxicity and in turn induces liver inflammation and apoptosis, resulting in non-alcoholic steatohepatitis (NAS ...

Amyotrophic lateral sclerosis (ALS) is a devastating neurological disease for which there is no cure. Another lethal brain disease is stroke, which occurs when blood supply to the brain is disrupted by a blood vessel that bursts or becomes blocked. Neuroinflammation plays a key role in both of th ...

Cancer chemotherapy can produce severe side effects such as suppression of immune function and damage to heart muscle, gastrointestinal tract, and liver. If serious enough, tissue injury can be a major reason for late stage termination of drug discovery research projects, so it is becoming more impo ...

Targeted cancer therapy aims to block key signaling pathways that are critical for tumor cell growth and survival. The blockage eventually results in cell death via apoptosis and tumor growth suppression. Encouraged by the success in clinical development, many academic and pharmaceutical researcher ...

Visualization and quantification of Computed Tomography (CT) scans is ideally performed on artifact free images. Materials with a high linear attenuation coefficient, such as metal, cause significant artifacts in the reconstructed image. Unfortunately, the use of metal is unavoidable in some orthopa ...

Introduction: Reactive oxygen species (ROS) play a critical role in a wide variety of disease conditions like cancer, inflammation, neurodegenerative disorders and oxidative stress. Highly sensitive and specific optical probes (fluorescent, luminescent or chemiluminescent probes) are therefore requi ...

Targeted cancer therapy aims to block key signaling pathways that are critical for tumor cell growth and survival. The blockage eventually results in cell death via apoptosis and eventual tumor growth suppression. This strategy has proven to be quite effective, and the FDA has approved several targe ...

Drug induced liver injury (DILI) is a major reason for late stage,termination of drug discovery research projects, so assessment is,being integrated earlier in the drug development process. Some,chemicals can produce different forms of hepatic injury in mice,including the two most common forms, chol ...

The ability to image protein-protein interactions (PPIs) in vivo has important implications for a wide variety of biological research endeavors, including drug discovery and molecular medicine. The visual representation, characterization, quantification, and timing of these biological proc ...

Viral diseases have emerged and re-emerged throughout history, and as the human population continues to increase globally, so will the frequency of viral pandemics. Not only have Ebola and COVID-19 demonstrated most recently mankind’s vulnerability to contagious diseases, but also the challenges ...

The primary goal of preclinical imaging is to improve the odds of clinical success and reduce drug discovery and development time and costs. Advances in non-invasive in vivo imaging techniques have raised the use of animal models in drug discovery and development to a new level by enabling quick ...