IVISense™ Folate Receptor 680 fluorescence imaging probe (FolateRSense™) is highly specific and sensitive in its detection of Folate Receptor alpha (FRa).
Used with in vivo imaging systems such as 爱游戏平台注册登录 's industry leading IVIS® platform, this targeted probe enables the non-invasive visualization and quantification of FR expression in highly metabolic cells such as tumor cells.
For research use only. Not for use in diagnostic procedures.
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Folate receptors are a family of cell surface receptors that bind the essential vitamin folic acid (folate, vitamin B9). These receptors are upregulated in highly metabolic cells and over-expression of FRA protein is associated with tumor growth, as uptake of folic acid is a necessary part of tumor metabolism.
Folate is essential for cellular metabolism and DNA synthesis, methylation, and repair. High metabolic cells such as proliferating cancer cells have increased demand for folate to maintain their accelerated DNA synthesis; thus overexpression of folate receptors (FRs) is a recognized biomarker of many tumors, though tumors can differ in their dependence on folate metabolism.
| Fluorescent Agent Type | Targeted |
|---|---|
| Optical Imaging Classification | Fluorescence Imaging |
| Product Brand Name | IVISense |
| Quantity in a Package Amount | 1.0 Units |
| Shipping Condition | Ambient |
| Therapeutic Area | Inflammation, Oncology/Cancer |
| Unit Size | 1 Vial (10 doses) |
| Wave Length | 680 nm |
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Overexpression of Folate Receptor (FR) protein is associated with tumor growth, and uptake of folic acid is a necessary part of tumor metabolism. The FolateRSense imaging agent is highly specific and sensitive in its detection of FR and can be used to closely monitor and quantitate tumor growth and ...
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Folic acid (vitamin B9) is an essential nutrient required by eukaryotic cells for survival that is acquired and internalized via folate receptors (FR) on the cell surface. In particular, it is the highly metabolic cells that upregulate FR, and many different human tumor cells, including ovarian, bre ...
FolateRSense 680 in vivo fluorescent imaging agent protocol
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