Integrins are a superfamily of transmembrane cell surface receptors that mediate signal transduction, cell-to-cell interaction, and cell-to-extracellular matrix adhesion - key processes for healthy cells as well as progression of disease states such as atherosclerosis and cancer, where integrins contribute to angiogenesis, tumorigenesis, and metastasis.
Among this superfamily, αvβ3 integrin holds promise as a therapeutic target in areas such as immuno-oncology, where αvβ3 integrin may prevent tumors from evading the immune system. 爱游戏平台注册登录 's IVISsense™ Integrin Receptor fluorescent probes (IntegriSense™) are designed to target αvβ3 integrin for monitoring tumor growth, angiogenesis and assessing treatment efficacy.
For research use only. Not for use in diagnostic procedures.
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IVISense Integrin Receptor 750 fluorescent imaging probe for in vivo detection of αvβ3 integrin is a low molecular weight peptidomimetic antagonist coupled to a red fluorochrome. This validated, high affinity (Kd = 4.2 nM) fluorescent probe has improved circulation half-life and specificity over RDG peptide-based agents, with selectivity 5-20x for αvβ3 integrin, for precise detection of αvβ3 integrins. This integrin-targeted molecular imaging agent enables non-invasive imaging to better understand biological processes, and disease biology and progression.
Including IVISense Integrin Receptor 750 fluorescent agent in careful experimental design allows for multiplexing with other channels and/or imaging times, and can be paired with other probes to achieve maximum efficiency and flexibility in your imaging studies.
| 熒光劑類型 | Targeted |
|---|---|
| 光學成像分類 | Fluorescence Imaging |
| 產品品牌名稱 | IVISense |
| 包裝量 | 1.0 Units |
| 運輸條件 | 藍冰 |
| 治療領域 | Angiogenesis, Atherosclerosis, Oncology/Cancer |
| 產品尺寸 | 1 Vial (10 doses) |
| 波長 | 750 nm |
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