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Matrix metalloproteinases (MMPs) are calcium-dependent zinc containing endopeptidases responsible for the degradation of most of extracellular matrix proteins during organogenesis, growth and normal tissue turnover. MMPs play a role in almost every biological cell process from embryo implantation to cell death and have been implicated in a wide range of diseases including inflammation, arthritis, pulmonary disease, cancer and more.
爱游戏平台注册登录 ’s IVISense™ MMP NIR activatable fluorescence probes (MMPSense®) are designed to evaluate many disease related processes including cancer progression, rheumatoid arthritis, pulmonary disease and more as well as evaluating therapeutic efficacy of potential drug candidates.
For research use only. Not for use in diagnostic procedures.
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IVISense MMP 680 is excited by 680 + 10 nm excitation light, and emits at 700 + 10 nm. MMP 680 has an optimal imaging window of 24-36 hours after injection, allowing workflow flexibility in acquiring data in large animal cohorts. Including IVISense MMP 680 in careful experimental design allows for multiplexing with other channels and/or imaging times, and so can be paired with other probes to achieve maximum efficiency and flexibility in imaging.
Fluorescent Agent Type | Activatable |
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Optical Imaging Classification | Fluorescence Imaging |
Product Brand Name | IVISense |
Quantity in a Package Amount | 1.0 Units |
Shipping Condition | Blue Ice |
Therapeutic Area | Atherosclerosis, Arthritis, Inflammation, Oncology/Cancer |
Unit Size | 1 Vial (10 doses) |
Wave Length | 680 nm |
Epifluorescence (2D) imaging of superficially implanted mouse tumor xenograft models offers a fast and simple method for assessing tumor progression or response to therapy. This approach for tumor assessment requires the use of near infrared (NIR) imaging agents specific for different aspects of tum ...
Our comprehensive range of bioluminescent and fluorescent imaging reagents provide researchers with the necessary tools to better understand early disease-related biological changes, track disease progression, help guide the drug discovery process, and evaluate efficacy and safety of drug candida ...
MMPSense 680 Activatable Fluorescent Imaging Agent
Researchers trust our in vivo imaging solutions to give them reliable, calibrated data that reveals pathway characterization and therapeutic efficacies for a broad range of indications. Our reagents, instruments, and applications support have helped hundreds of research projects over the years. And ...
Fluorescence molecular imaging is the visualization of cellular and biological function in vivo to gain deeper insights into disease processes and treatment effects. Designing an effective study from the beginning can help save time and resources.
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The goal of in vivo fluorescence molecular imaging is to enable non-invasive visualization and quantification of cellular and biological functioning to better understand and characterize disease processes and treatment effects earlier within the context of a biological system.
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The primary goal of preclinical imaging is to improve the odds of clinical success and reduce drug discovery and development time and costs. Advances in non-invasive in vivo imaging techniques have raised the use of animal models in drug discovery and development to a new level by enabling quick ...