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IVISense MMP 750 FAST Fluorescent Probe (MMPSense)

Matrix metalloproteinases (MMPs) are calcium-dependent zinc containing endopeptidases responsible for the degradation of most of extracellular matrix proteins during organogenesis, growth and normal tissue turnover. MMPs play a role in almost every biological cell process from embryo implantation to cell death and have been implicated in a wide range of diseases including inflammation, arthritis, pulmonary disease, cancer and more.

爱游戏平台注册登录 ’s IVISense MMP NIR activatable fluorescence probes (MMPSense®) are designed to evaluate many disease related processes including cancer progression, rheumatoid arthritis, pulmonary disease and more as well as evaluating therapeutic efficacy of potential drug candidates.

For research use only. Not for use in diagnostic procedures.

貨號
SKU顯示名稱
NEV10126
IVISense MMP 680 Fluorescent Probe (MMPSense)
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NEV10100
IVISense MMP 645 FAST Fluorescent Probe (MMPSense)
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NEV10168
IVISense MMP 750 FAST Fluorescent Probe (MMPSense)
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詳細信息

IVISense MMP 750 FAST is excited by 749 nm excitation light, and emits at 775 nm. MMP 750 FAST is a member of a family of activatable fluorescent imaging agents comprising a novel architecture termed F.A.S.T. (Fluorescent Activatable Sensor Technology), that allows for an earlier optimal imaging window of 12-24 hours after injection, facilitating detection of MMP activity changes in acute models of inflammation or stroke. In addition, the 750 nm wavelength is optimal for minimizing the impact of autofluorescence and chow-related fluorescence that can interfere with image quality. Including IVISense MMP 750 FAST in careful experimental design allows for multiplexing with other channels and/or imaging times, and so can be paired with other probes to achieve maximum efficiency and flexibility in imaging.

規格

熒光劑類型 Activatable
光學成像分類 Fluorescence Imaging
產品品牌名稱 IVISense
包裝量 1.0 Units
運輸條件 藍冰
治療領域 Atherosclerosis, Arthritis, Inflammation, Oncology/Cancer
產品尺寸 1 Vial (10 doses)
波長 750 nm
資源
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Ebook

了解更多請點擊下載小動物活體成像解決方案

Researchers trust our in vivo imaging solutions to give them reliable, calibrated data that reveals pathway characterization and therapeutic efficacies for a broad range of indications. Our reagents, instruments, and applications support have helped hundreds of research projects over the years. And ...

PDF 4 MB

產品手冊

In Vivo Imaging Reagents

Our comprehensive range of bioluminescent and fluorescent imaging reagents provide researchers with the necessary tools to better understand early disease-related biological changes, track disease progression, help guide the drug discovery process, and evaluate efficacy and safety of drug candida ...

PDF 1 MB

單頁

Best Practices for Designing An Effective In Vivo Fluorescence Imaging Study

Fluorescence molecular imaging is the visualization of cellular and biological function in vivo to gain deeper insights into disease processes and treatment effects. Designing an effective study from the beginning can help save time and resources.

Learn about several important best p ...

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指南

IVISense™ Fluorescent Probe Selector Guide for Oncology Research

The goal of in vivo fluorescence molecular imaging is to enable non-invasive visualization and quantification of cellular and biological functioning to better understand and characterize disease processes and treatment effects earlier within the context of a biological system.

This s ...

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數據單表

MMPSense 750 FAST (Protocol)

MMPSense 750 FAST activatable fluorescent imaging agent protocol

PDF 257 KB

海報

Combined efficacy & toxicity imaging following acute 5-FU treatment of HT-29 tumor xenografts

Cancer chemotherapy can produce severe side effects such as suppression of immune function and damage to heart muscle, gastrointestinal tract, and liver. If serious enough, tissue injury can be a major reason for late stage termination of drug discovery research projects, so it is becoming more impo ...

PDF 1 MB

白皮書

The Role of In Vivo Imaging in Drug Discovery and Development

The primary goal of preclinical imaging is to improve the odds of clinical success and reduce drug discovery and development time and costs. Advances in non-invasive in vivo imaging techniques have raised the use of animal models in drug discovery and development to a new level by enabling quick ...

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