Proteases perform a fundamental role in protein regulation. Altered activity of lysosomal cathepsins, a class of protease, can indicate many disease-related processes, such as those involved in cancer, inflammation, arthritis, cardiovascular and many others. The ability to detect and quantify normal as well as altered protease cathepsin activity in vivo allows the progress and severity of these disease states to be tracked and interrogated over time.
爱游戏平台注册登录 ’s IVISense™ Pan Cathepsin fluorescent probes (ProSense®) are versatile pan-cathepsin-activatable NIR agents for imaging various disease-related events. These activatable probes are optically silent in their intact state and become highly fluorescent following protease-mediated cleavage and activation.
For research use only. Not for use in diagnostic procedures.
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IVISense Pan Cathepsin 680 is our original “Smart” cathepsin probe; rather than targeting all protease, smart probes become fluorescent only after enzymatic cleavage, which keeps background down and allows detection of activated protease. 24h imaging at 680 nm.
Fluorescent Agent Type | Activatable |
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Optical Imaging Classification | Fluorescence Imaging |
Product Brand Name | IVISense |
Quantity in a Package Amount | 1.0 Units |
Shipping Condition | Blue Ice |
Therapeutic Area | Atherosclerosis, Arthritis, Inflammation, Oncology/Cancer |
Unit Size | 1 Vial (10 doses) |
Wave Length | 680 nm |
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APP_Protocol_ProSense 680 Activatable Fluorescent imaging agent Protocol
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