Ketanserin, (R41468), [Benzoyleneurea-³H], 250 µCi (9.25MBq)

Ketanserin is used as a radioligand for serotonin 5-HT2 serotonin receptors. Ketanserin is used clnical as an antihypertensive agent.

We offer both agonist and antagonist radioligands for autoradiographic visualization or performing saturation and competition assays to determine receptor expression levels (Bmax), dissociation constants (Kd), association and dissociation rates (kon and koff), and inhibitor constants (Ki) for a variety of receptors. We develop our radioligands to the highest specific activity possible and provide high purity resulting in low non-specific binding products. Each of our ultra-pure radioligands is fully characterized for pharmacological action and validated in receptor binding assays.

Radiolabeled ligands remain the most sensitive method for probing receptor binding biology; yielding unprecedented sensitivity gives results that technicians and scientists can trust. For over 50 years, 爱游戏平台注册登录 has been a leading supplier of New England Nuclear (NEN) radiochemicals, liquid scintillation cocktails, vials and nuclear counting detection instruments.

References:

1. Toshiyuki Ueki, Kazushige Mizoguchi, Takuji Yamaguchi, Akinori Nishi, Kyoji Sekiguchi, Yasushi Ikarashi, Yoshio Kase, Yokukansan, a traditional Japanese medicine, decreases head-twitch behaviors and serotonin 2A receptors in the prefrontal cortex of isolation-stressed mice, In Journal of Ethnopharmacology, Volume 166, 2015, Pages 23-30.

2. Lydia Schiller, Markus Donix, Monika Jähkel, Jochen Oehler, Serotonin 1A and 2A receptor densities, neurochemical and behavioural characteristics in two closely related mice strains after long-term isolation, In Progress in Neuro-Psychopharmacology and Biological Psychiatry, Volume 30, Issue 3, 2006, Pages 492-503.

3. Daniel Hoyer, Günter Engel, Hans O. Kalkman, Molecular pharmacology of 5-HT1 and 5-HT2 recognition sites in rat and pig brain membranes: Radioligand binding studies with [³H]5-HT, [³H]8-OH-DPAT, (−)[125I]iodocyanopindolol, [³H]mesulergine and [³H]Ketanserin, In European Journal of Pharmacology, Volume 118, Issues 1–2, 1985, Pages 13-23.