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Membrane Target Systems are quality assured frozen membranes from cells that express recombinant or endogenous receptors. We submit every batch of receptor to stringent quality control testing that includes saturation radioligand binding assay to determine receptor concentration (Bmax) and affinity (Kd). Competition binding assays are performed determine affinity (Ki) against known reference agonists and antagonists. GTPĪ³S data is also provided for some of our Gi coupled receptors.
Membranes are carefully prepared and ready for a variety of HTS applications, including radioligand binding (using either proximity methods, such as FlashPlate, or classical filtration methods). Products are packaged as frozen crude membrane preparations. One assay unit is defined as micrograms of protein, defined by competition binding assay (filtration). A complete product description and recommended protocol are included on the Certificate of Analysis.
| Assay Target Class | GPCR |
|---|---|
| Assay Target Type | Membrane preparation |
| Assay Validated | Binding |
| G-Alpha Natural Receptor | Gq/G11 |
| Host | CHO-K1 |
| Product Brand Name | Membrane Target Systems |
| Receptor Type | Neurokinin NK3 |
| Shipping Condition | Dry Ice |
| Therapeutic Area | Central Nervous System |
| Unit Size | 400 units |
Discover a comprehensive collection of GPCR cell lines, membrane preparations, and complementary radioligands designed to drive your GPCR research. Utilize this selection guide to easily identify:
