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Protein Clear^™ HR Reagent Kit

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The LabChip^® GXII Touch microfluidics Protein Clear HR assay provides rapid (65 seconds/ sample) high-resolution protein purity analysis for monoclonal antibody (mAb) process development formulation, stability and manufacturing quality control. Enabling the detection and visualization of impurities within a sample, down to 5 ng/µL .

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CLS960014

793.00 USD

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Overview

The Protein Clear HR assay is designed for the high-resolution protein purity assessment of monoclonal antibodies (mAbs) within research and development, enabling the detection and visualization of impurities within a sample, down to 5 ng/µL. With the analytical power and speed of the LabChip^® GXII Touch^™ system and IntelliChip^™ assay optimization technology, you can accelerate your protein development workflows with unmatched throughput and reproducibility.

Protein Clear HR and Protein QC Reagent Kits are interchangeable. For use with Protein Clear HR LabChips CLS148695 and CLS148696.

Detect and visualize impurity peaks in 65 seconds
Innovative IntelliChip^™ technology provides intra- and inter-run reproducibility
Limit of Detection (LOD) sensitivity of 5 ng/µL
Baseline resolution of proteins as close as 0.2%, determined by mass spectrometry

Kit contents:

Dye Solution
Sample Buffer
Protein Gel Matrix
Protein Ladder
Lower Marker
Wash Buffer
VeriMAb^™ Standard (reference standard)

System Requirements:

The Protein Clear HR assay requires a LabChip GXII Touch instrument with V1.6 software or newer and Data Reviewer V5.4 or newer.

Specifications

Product Brand Name	LabChip GXII
Research Areas	Drug Development & Manufacturing, Drug Discovery & Manufacturing, Food & Agriculture
Sample Type	Protein
Shipping Condition	Dry Ice

Configurations

Protein Clear HR Assay Specifications
Parameter	Specification
Sizing Range	14-250 kDa
Maximum Sample Concentration	2000 ng/μL
Sizing Resolution*	Resolution > 1.0 for VeriMAb reference standard
Sizing Precision RSD (CV)	<2%
Relative Migration time Precision RSD (CV)	<2%
Percent Purity Reproducibility	<0.5% Main Non Reduced IgG <5% all other peaks
Sensitivity (LOD)	5 ng/μL (mAb, non-reduced main peak)
Linear Concentration Range	10 – 1000 ng/ μL (mAb, non-reduced main peak)
Linearity (R^2)	>0.995
Separation Time per sample	65 seconds
Maximum number of samples per calibration	96
Chip Lifetime	400 samples
Reagent Kit Primes	10
Minimum sample volume	2 μL