Ryanodine, [9,21-³H(N)]-, 250µCi (9.25MBq)

Ryanodine is a plant alkaloid and natural ligand for the ryanodinen receptor (RyR), a class of calcium channels (Ca²⁺ channels).

We offer both agonist and antagonist radioligands for autoradiographic visualization or performing saturation and competition assays to determine receptor expression levels (B_max), dissociation constants (K_d), association and dissociation rates (k_on and k_off), and inhibitor constants (K_i) for a variety of receptors. We develop our radioligands to the highest specific activity possible and provide high purity resulting in low non-specific binding products. Each of our ultra-pure radioligands is fully characterized for pharmacological action and validated in receptor binding assays.

Radiolabeled ligands remain the most sensitive method for probing receptor binding biology; yielding unprecedented sensitivity gives results that technicians and scientists can trust. For over 50 years, 爱游戏平台注册登录 has been a leading supplier of New England Nuclear (NEN) radiochemicals, liquid scintillation cocktails, vials and nuclear counting detection instruments.

References for NET950:

1. Araki, T., Kato, H., Shuto, K., Oshima, Y. and Itoyama, Y. (1998), Postischemic changes of [3H]nimodipine and [3H]ryanodine binding in the gerbil striatum and hippocampus. European Journal of Neurology, 5: 195–201.