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SDF-1α (human, recombinant), [125I]-, 25µCi

Stromal cell-derived factor 1 alpha (SDF-1α; CXCL12), labeled with 125I. SDF-1α binds the CXCR4 receptor.

貨號
產品尺寸
NEX346005UC
5 µCi
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NEX346025UC
25 µCi
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詳細信息

We offer radioligands and radiolabeled biomolecules to use as tracers, for radioimmunoassays (RIAs), for autoradiographic visualization, or for performing saturation and competition radioligand binding assays to determine receptor expression levels (Bmax), dissociation constants (Kd), association and dissociation rates (kon and koff), and inhibitor constants (Ki) for a variety of receptors. We develop our radioligands to the highest specific activity possible and provide high purity resulting in low non-specific binding products. Each of our ultra-pure radiolabeled compounds is fully characterized for pharmacological action and validated in binding assays.

Radiochemicals remain the most sensitive method for probing binding biology; yielding unprecedented sensitivity gives results that technicians and scientists can trust. For over 50 years, 爱游戏平台注册登录 has been a leading supplier of New England Nuclear (NEN) radiochemicals, liquid scintillation cocktails, vials and nuclear counting detection instruments.

References for NEX346:

  1. Asano, S., Kitatani, K., Taniguchi, M., Hashimoto, M., Zama, K., Mitsutake, S., Igarashi, Y., Takeya, H., Kigawa, J., Hayashi, A., Umehara, H., Okazaki, T. (2012), Regulation of cell migration by sphingomyelin synthases: sphingomyelin in lipid rafts decreases responsiveness to signaling by the CXCL12/CXCR4 pathway. Mol Cell Biol, 32 (16): 3242-3252.
  2. Howard, O. M. Z., Korte, T., Tarasova, N. I., Grimm, M., Turpin, J. A., Rice, W. G., Michejda, C. J., Blumenthal, R. and Oppenheim, J. J. (1998), Small molecule inhibitor of HIV-1 cell fusion blocks chemokine receptor-mediated function. J Leukoc Biol, 64: 6–13.

規格

濃度 45.7 µCi/mL
檢測方法 Radiometric
新鮮的很多天 Third Monday of each month
標簽位置 Nominally Labeled
產品品牌名稱 NEN Radiolabeled Ligands
放射性同位素 I-125
放射性核素 125I
受體類型 Chemokine
運輸條件 幹冰
特殊訂購信息 This is a radioactive product - shipping address must have a license to receive radioactive materials.
治療領域 CNS & Neurologic, Inflammation
產品尺寸 25 µCi
資源
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Since 1985, the unique NENSure system has set the standard for radiochemical packaging. Based on proven performance over millions of shipments, the system provides: Ease of use, Safe storage of unused product and Reduced radiation exposure. Many NEN brand research products, including 32P-, 33P-, 35 ...

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