Substance-P (9-Sar, 11-Met(O₂)), [2-Prolyl-3,4-³H]-, 50µCi (1.85MBq)

Substance-P acts as an antagonist at neurokinin-1 receptors, and is used to treat depression. Neurokinin receptors play a role in neuroinflammation in infection and neurodegenerative diseases.

We offer both agonist and antagonist radioligands for autoradiographic visualization or performing saturation and competition assays to determine receptor expression levels (B_max), dissociation constants (K_d), association and dissociation rates (k_on and k_off), and inhibitor constants (K_i) for a variety of receptors. We develop our radioligands to the highest specific activity possible and provide high purity resulting in low non-specific binding products. Each of our ultra-pure radioligands is fully characterized for pharmacological action and validated in receptor binding assays.

Radiolabeled ligands remain the most sensitive method for probing receptor binding biology; yielding unprecedented sensitivity gives results that technicians and scientists can trust. For over 50 years, 爱游戏平台注册登录 has been a leading supplier of New England Nuclear (NEN) radiochemicals, liquid scintillation cocktails, vials and nuclear counting detection instruments.

References for NET1025:

1. Singewald, N., Chicchi, G. G., Thurner, C. C., Tsao, K.-L., Spetea, M., Schmidhammer, H., Sreepathi, H. K., Ferraguti, F., Singewald, G. M. and Ebner, K. (2008), Modulation of basal and stress-induced amygdaloid substance P release by the potent and selective NK1 receptor antagonist L-822429. Journal of Neurochemistry, 106: 2476–2488.
2. Mantyh, P.W., Pinnock, R.D., Downes, D.P., Goedert, M., Hunt, S.P. (1984), Correlation between inositol phospholipid hydrolysis and substance P receptors in rat CNS. Nature, 309: 795–797.