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Thyroxine, ([125I]-T4), L-[125I]-, 500µCi (18.5MBq), Specific Activity: 135-165µCi (5.00-6.11MBq)/µg

Thyroxine (T4) labeled with 125I. Thyroxine is a thyroid hormone that is responsible for regulation or metabolism. T4 detection by radioimmunoassay is a common test of thyroid disease. This product is offered at three specific activities. Specific activity indicates how much radioactivity there is per molecule of thyroxine. Several of our 125I-labeled ligands are offered at maximum specific activity (2200 Ci/mmol if one 125I labeling site is available, 4400 Ci/mmol if two labeling sites are available).

貨號
產品尺寸
NEX111100UC
100 µCi
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NEX111250UC
250 µCi
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NEX111500UC
500 µCi
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詳細信息

We offer radioligands and radiolabeled biomolecules to use as tracers, for radioimmunoassays (RIAs), for autoradiographic visualization, or for performing saturation and competition radioligand binding assays to determine receptor expression levels (Bmax), dissociation constants (Kd), association and dissociation rates (kon and koff), and inhibitor constants (Ki) for a variety of receptors. We develop our radioligands to the highest specific activity possible and provide high purity resulting in low non-specific binding products. Each of our ultra-pure radiolabeled compounds is fully characterized for pharmacological action and validated in binding assays.

Radiochemicals remain the most sensitive method for probing binding biology; yielding unprecedented sensitivity gives results that technicians and scientists can trust. For over 50 years, 爱游戏平台注册登录 has been a leading supplier of New England Nuclear (NEN) radiochemicals, liquid scintillation cocktails, vials and nuclear counting detection instruments.

References for NEX111:

  1. Donald F. Sellitti, Yueh-Chu L. Tseng and Keith R. Latham, (1983), Nuclear Thyroid Hormone Receptors in C3H/HeN Mouse Mammary Glands and Spontaneous Tumors, Cancer Research 43 (3): 1030-1038.

References for NEX111H:

  1. Sotelo-Rivera, I., Jaimes-Hoy, L., Cote-Vélez, A., Espinoza-Ayala, C., Charli, J.-L. and Joseph-Bravo, P. (2014), An Acute Injection of Corticosterone Increases Thyrotrophin-Releasing Hormone Expression in the Paraventricular Nucleus of the Hypothalamus but Interferes with the Rapid Hypothalamus Pituitary Thyroid Axis Response to Cold in Male Rats. J Neuroendocrinol, 26: 861–869.

References for NEX111X:

  1. DuRant, S.E., Carter, A.W., Denver, R.J., Hepp, G.R., Hopkins, W.A., (2014), Are thyroid hormones mediators of incubation temperature-induced phenotypes in birds? Biology Letters, 10: 20130950.

規格

濃度 345 µCi/mL
檢測方法 Radiometric
新鮮的很多天 Third Monday of each month
標簽位置 Nominally Labeled
分子量 776.9
產品品牌名稱 NEN Radiolabeled Ligands
放射性同位素 I-125
放射性核素 125I
運輸條件 環境
特殊訂購信息 This is a radioactive product - shipping address must have a license to receive radioactive materials.
治療領域 Cardiovascular, Metabolic Disorders
產品尺寸 500 µCi
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