Triiiodothyronine, L-3, 5, 3'-[¹²⁵I], 100 µCi (3.7 MBq), Specific Activity: 3300 µCi (122 MBq)/µg

We offer radioligands and radiolabeled biomolecules to use as tracers, for radioimmunoassays (RIAs), for autoradiographic visualization, or for performing saturation and competition radioligand binding assays to determine receptor expression levels (B_max), dissociation constants (K_d), association and dissociation rates (k_on and k_off), and inhibitor constants (K_i) for a variety of receptors. We develop our radioligands to the highest specific activity possible and provide high purity resulting in low non-specific binding products. Each of our ultra-pure radiolabeled compounds is fully characterized for pharmacological action and validated in binding assays.

Radiochemicals remain the most sensitive method for probing binding biology; yielding unprecedented sensitivity gives results that technicians and scientists can trust. For over 50 years, 爱游戏平台注册登录 has been a leading supplier of New England Nuclear (NEN) radiochemicals, liquid scintillation cocktails, vials and nuclear counting detection instruments.

References for NEX110:

1. McIver, C.R., Shaw, IC., Gin, S., Ellis, M.J. (2013), Can thyroid hormone mimics affect thyroid hormone measurement by immunoassay?, Clinical Biochemistry, Volume 46, Issues 13–14, Pages 1302-1304.
2. Mantzos, J.D., Yialouris, P.P. (1982), A simple and reproducible method for the estimation of triiodothyronine uptake (thyroxine binding index) using a new adsorbent, Clinical Biochemistry, Volume 15, Issue 2, Pages 76-79.

References for NEX110H:

1. McConway, M.G., Chapman, R.S. (1986) Application of solid-phase antibodies to radioimmunoassay Evaluation of two polymeric microparticles, Dynospheres and nylon, activated by carbonyldiimidazole or tresyl chloride, Journal of Immunological Methods, Volume 95, Issue 2, Pages 259-266.
2. Selliti, D.F., Latham, K.R. (1983) Multiple affinity classes of saturable triiodothyronine binding in mouse liver nuclear extract demonstrated using high-performance size exclusion chromatography, Journal of Chromatography A, Volume 268, Pages 300-305.

References for NEX110X:

1. Glynn, N., Kenny, H., Quisenberry, L., Halsall, D. J., Cook, P., Kyaw Tun, T., McDermott, J. H., Smith, D., Thompson, C. J., O'Gorman, D. J., Boelen, A., Lado-Abeal, J. and Agha, A. (2017), The effect of growth hormone replacement on the thyroid axis in patients with hypopituitarism: in vivo and ex vivo studies. Clin Endocrinol, 86: 747–754.