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Triiiodothyronine, L-3, 5, 3'-[125I], 500 µCi (18.5 MBq), Specific Activity: 3300 µCi (122 MBq)/µg

Triiodothyronine (T3) labeled with 125I. Triiodothyronine is a thyroid hormone that affects growth and development, body temperature, and heart rate. T3 detection by radioimmunoassay is a common test of thyroid gland function. This product is offered at three specific activities. Specific activity indicates how much radioactivity there is per molecule of ligand. Several of our 125I-labeled ligands are offered at maximum specific activity (2200 Ci/mmol if one 125I labeling site is available, 4400 Ci/mmol if two labeling sites are available).

貨號
產品尺寸
Spec Activity
NEX110100UC
100 µCi
135-165 µCi/µg
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NEX110250UC
250 µCi
135-165 µCi/µg
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NEX110500UC
500 µCi
135-165 µCi/µg
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NEX110H100UC
100 µCi
1080-1320 µCi/µg
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NEX110H250UC
250 µCi
1080-1320 µCi/µg
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NEX110H500UC
500 µCi
1080-1320 µCi/µg
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NEX110X100UC
100 µCi
3300 µCi/µg
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NEX110X250UC
250 µCi
3300 µCi/µg
更多
NEX110X500UC
500 µCi
3300 µCi/µg
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詳細信息

We offer radioligands and radiolabeled biomolecules to use as tracers, for radioimmunoassays (RIAs), for autoradiographic visualization, or for performing saturation and competition radioligand binding assays to determine receptor expression levels (Bmax), dissociation constants (Kd), association and dissociation rates (kon and koff), and inhibitor constants (Ki) for a variety of receptors. We develop our radioligands to the highest specific activity possible and provide high purity resulting in low non-specific binding products. Each of our ultra-pure radiolabeled compounds is fully characterized for pharmacological action and validated in binding assays.

Radiochemicals remain the most sensitive method for probing binding biology; yielding unprecedented sensitivity gives results that technicians and scientists can trust. For over 50 years, 爱游戏平台注册登录 has been a leading supplier of New England Nuclear (NEN) radiochemicals, liquid scintillation cocktails, vials and nuclear counting detection instruments.

References for NEX110:

  1. McIver, C.R., Shaw, IC., Gin, S., Ellis, M.J. (2013), Can thyroid hormone mimics affect thyroid hormone measurement by immunoassay?, Clinical Biochemistry, Volume 46, Issues 13–14, Pages 1302-1304.
  2. Mantzos, J.D., Yialouris, P.P. (1982), A simple and reproducible method for the estimation of triiodothyronine uptake (thyroxine binding index) using a new adsorbent, Clinical Biochemistry, Volume 15, Issue 2, Pages 76-79.

References for NEX110H:

  1. McConway, M.G., Chapman, R.S. (1986) Application of solid-phase antibodies to radioimmunoassay Evaluation of two polymeric microparticles, Dynospheres and nylon, activated by carbonyldiimidazole or tresyl chloride, Journal of Immunological Methods, Volume 95, Issue 2, Pages 259-266.
  2. Selliti, D.F., Latham, K.R. (1983) Multiple affinity classes of saturable triiodothyronine binding in mouse liver nuclear extract demonstrated using high-performance size exclusion chromatography, Journal of Chromatography A, Volume 268, Pages 300-305.

References for NEX110X:

  1. Glynn, N., Kenny, H., Quisenberry, L., Halsall, D. J., Cook, P., Kyaw Tun, T., McDermott, J. H., Smith, D., Thompson, C. J., O'Gorman, D. J., Boelen, A., Lado-Abeal, J. and Agha, A. (2017), The effect of growth hormone replacement on the thyroid axis in patients with hypopituitarism: in vivo and ex vivo studies. Clin Endocrinol, 86: 747–754.

規格

濃度 353 µCi/mL
檢測方法 Radiometric
新鮮的很多天 Third Monday of each month
標簽位置 Specifically Labeled
分子量 649.0
產品品牌名稱 NEN Radiolabeled Ligands
放射性同位素 I-125
放射性核素 125I
運輸條件 環境
Spec Activity 3300 µCi/µg
特殊訂購信息 This is a radioactive product - shipping address must have a license to receive radioactive materials.
治療領域 Metabolic Disorders
產品尺寸 500 µCi
資源
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