WAY100635, [Methoxy-³H], 250 µCi

WAY-100635 acts as an antagonist at 5-HT_1A receptors, and as an agonist at dopamine D₄ receptors. The serotonin 5-HT_1A receptors belong to a group of GPCRs that are involved in neuromodulation, and are potential drug targets for anxiety and depression. Dopamine D₄ receptors are part of a group of GPCRs that are potential drug targets for schizophrenia, bipolar disorder, ADHD, and Parkinson disease.

We offer both agonist and antagonist radioligands for autoradiographic visualization or performing saturation and competition assays to determine receptor expression levels (B_max), dissociation constants (K_d), association and dissociation rates (k_on and k_off), and inhibitor constants (K_i) for a variety of receptors. We develop our radioligands to the highest specific activity possible and provide high purity resulting in low non-specific binding products. Each of our ultra-pure radioligands is fully characterized for pharmacological action and validated in receptor binding assays.

Radiolabeled ligands remain the most sensitive method for probing receptor binding biology; yielding unprecedented sensitivity gives results that technicians and scientists can trust. For over 50 years, 爱游戏平台注册登录 has been a leading supplier of New England Nuclear (NEN) radiochemicals, liquid scintillation cocktails, vials and nuclear counting detection instruments.